Matrix Metalloproteinases in Cancer Progress

Dear Colleagues,

The importance of MMPs in connective tissue remodeling and matrix degradation have been known for a long time. Increasingly, it is recognized that these enzymes have critical roles in signal transduction and gene regulation, and that they may have beneficial functions in normal homeostasis as well as in diseases. This Special Issue is dedicated to highlighting the more novel and innovative roles of secreted MMPs and their membrane bound counterparts, MT-MMPs, as mediators of cancer progression and as tumor suppressors. In addition, these enzymes may participate in cancers by functioning in organelles, such as exosomes and invadopodia. Thus, with their ubiquitous presence, they continue to represent attractive therapeutic targets and new strategies with improved efficacy are emerging. Finally, innovative models of cancers, such as zebrafish, may provide critical insights into how MMPs contribute to cancer progression.

Prof. Dr. Constance E. Brinckerhoff
Guest Editor

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