Diagnosis and Treatment for Bone Tumor and Sarcoma

Dear Colleagues,

Bone tumors include primary bone tumors initiating at the bone (sarcoma) and secondary bone tumors, commonly called bone metastases, where the cancer starts somewhere else in the body and then spreads to the bone. Primary Bone tumors, including osteosarcoma and Ewing sarcoma, are primary bone tumors mainly affecting children and young adults. Current treatment has not progressed for the last 40 years and is based on a multimodal therapy including neo-adjuvant chemotherapy, surgical resection, and radiotherapy in some cases. With these therapeutic options, the survival rate reaches 60-70% for the localized forms, but drastically drop down to 25-30% for the bad responders to treatment or for patients with metastasis at the diagnosis. Bone metastases are much more frequent than primary bone tumors with the majority in breast and prostate cancer (70% of incidence) and are associated with degradation of patient’s quality of life and significantly increased the mortality. Diagnosis of bone cancers is based on symptoms (e.g., pain, fractures, spinal cord compression, etc.) and imaging but still difficult to prematurely detect. In this context, a better knowledge of bone biology has become essential for clinicians and experts in bone cancer research. This Special Issue proposes a translational overview covering all aspects of primary bone tumors and bone metastases development including genomic and proteomic analyses, clinical analyses, recent advances in new therapies or clinical trials.

Dr. François Lamoureux
Guest Editor

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