Interplay between Signaling Pathways and Metabolism in Brain Tumors

Dear Colleagues,

The incidence of brain tumors is constantly increasing, with therapeutic approaches still remaining limited. Most malignant brain neoplasms are highly invasive, heterogeneous, neurologically destructive and resistant to therapies. One source of the therapeutic resistance of brain tumors stems from the complex interconnection of intracellular networks, such as signaling pathways and metabolism, which endows tumor cells with the ability to evade anti-cancer treatments. For instance, aberrant activation of signaling pathways enables tumor cells to resist cell death and maximize drug resistance through nutrient uptake from the microenvironment. Moreover, abnormal levels of some metabolites act as second messengers that can directly or indirectly regulate signaling pathways. Understanding the dynamics of the interplay between signaling pathways and metabolism in brain tumors is therefore expected to reveal novel therapeutic vulnerabilities and target treatments.

We are pleased to invite you to this Special Issue focusing on aspects of the interface between metabolism and signaling pathways, and their deregulation in brain tumors. This Special Issue aims to provide an up-to-date overview of signal transduction pathways and metabolic changes which contribute to the aggressive phenotypes of cancer cells and tumor progression that may serve as clinical markers to improve disease diagnosis, prognosis and therapy.

In this Special Issue, original research articles, perspectives and reviews that comprehensively address the latest discoveries in the field are invited.

We look forward to receiving your contributions. 

Prof. Dr. Christina Piperi
Prof. Dr. Elias A. El-Habr
Guest Editors

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