Immunotherapy in Melanoma: Recent Advances and Future Directions

Dear Colleagues,

Looking beyond the pandemic, immune-checkpoint inhibitors (ICIs) continue to offer long-term remission in melanoma, either in an adjuvant or a metastatic setting. At the same time, the development of new immunotherapeutic agents (e.g., relatlimab and bempegaldesleukin) or combinatorial regimens (e.g., immune/targeted combinations, intralesional infusions and ICIs) and the identification of intratumoral or circulating biomarkers continue to open new horizons and produce new questions for immune-mediated treatments. Issues such as the duration and the exact dose of anti-PD1/anti-PDL1 and anti-CTLA4 agents in metastatic and locoregional disease, the stage of early melanoma that should be treated with ICIs and the potential of intralesional infusions are still under consideration and an open field for debate. To this end, this Special Issue of Cancers aims to explore the constantly remodeled area of immunotherapy in melanoma management in the post-COVID-19 era and tries to recap where we are and where we are going in terms of the knowledge on immune-mediated therapies in melanoma.

We look forward to receiving your contributions.

Prof. Dr. Helen Gogas
Dr. Dimitrios C. Ziogas
Guest Editors

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