CDK Targeting in Cancer Therapy
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 9229
Special Issue Editor
Interests: target therapy in cancer; signal transduction pathways alterations in cancer; cell cycle inhibitors; malignant pleural mesothelioma; renal cell carcinoma
Special Issue Information
Dear Colleagues,
The deregulation of cell cycle is one of the key hallmarks of cancer. The cell cycle cyclin-dependent kinases (CDKs) play a critical role in the regulation of cell proliferation, by controlling the transition between cell cycle phases, and constitutive CDK activation is a common event in cancer cells. Anyway, more than twenty CDKs have been identified in mammalian cells with a wild range of function beyond cell cycle regulation, including DNA transcription, DNA replication, and DNA repair.
To date, CDK4/6 inhibitors have been approved for the treatment of metastatic hormone receptor positive breast cancer, even if several translational studies have proved their efficacy also in other cancer types, and several clinical trials are ongoing to evaluate the effectiveness in different solid tumor types, as either single agents or in combination strategies.
In addition, new selective inhibitors targeting other CDKs are under development and their efficacy has been evaluating in a variety of cancer types.
The aim of this Special Issue is to present a collection of both original studies and/or review, at the preclinical and clinical level, on the use of CDK inhibitors as an antitumoral strategy, to provide insights into their molecular mechanisms of action and possible resistance mechanisms.
Specific sub-topics covered may include but are not limited to the following:
- Evaluation of the efficacy of CDK inhibitors in solid tumor models, as single treatment or in combination with other target agents, immunotherapy, or chemotherapy;
- Identification of specific biomarkers of responsiveness;
- Mechanisms of resistance to CDK inhibitors which inevitably limit their clinical benefit, and strategies to overcome such resistance.
Prof. Dr. Mara A. Bonelli
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- CDK
- CDK inhibitors
- cell cycle
- cell proliferation
- Cyclin
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