CD26 and Cancer

There are several issues not yet known about CD26, although its enzymatic activity is a well-known target in diabetes treatments.

On one side, it has been proposed that CD4+ T cell subsets with CD26 show properties critical for improving cancer immunotherapy, as they have a rich chemokine receptor profile, profound cytotoxicity, resistance to apoptosis, enhanced stemness, and the capacity to regress and survive in solid tumours.

On the other side, the subsets of cancer stem cells expressing CD26 are known to be implicated in metastasis. Both branches of research match CD26 in enhanced migration and cell persistence.

Some advances have also been made on the role of the soluble form of CD26, which has been proposed as a biomarker of, mainly, lung and colorectal cancer, as well as on the existence of autoantibodies against CD26. The relationships between all these participants, however, are yet not well understood.

Prof. Oscar J. Cordero
Guest Editor

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