Latest Development in B Cell Malignancies

Dear Colleagues,

B cell malignancies are heterogeneous in terms of genetic alterations, biological mechanisms sustaining tumor cells and, consequently, disease outcome. Over the past few years, growing interest in critical pathways has led to the discovery and design of treatment options with groundbreaking results and changes in the clinical practice, such as ibrutinib and its derivatives, or venetoclax. It is now clear that both intrinsic features of malignant B cells and the microenvironment play a pivotal role in driving and sustaining malignant B cell evolution, and that this is a two-way relationship, where tumor cells shape the bystander populations toward tolerance and support. The current challenge is to dissect and deeply characterize the biology of B cell malignancies to understand the most significant mechanism behind B cell transformation and disease progression and find targetable weak spots. This Special Issue welcomes reviews, as well as original research articles.

Dr. Francesca Arruga
Dr. Federico Pozzo
Guest Editors

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