Impact of Social Determinants on Cancer Care

Dear Colleagues,

Cancer care disparities remain a critical challenge in oncology, deeply rooted in the complex interplay of social determinants of health (SDOH). These determinants, encompassing socioeconomic status, education, neighborhood environment, and social support networks, profoundly influence the entire spectrum of cancer care. Socioeconomic disadvantages often lead to delayed diagnoses and reduced access to advanced treatments, resulting in poorer clinical outcomes. Moreover, geographic and environmental factors contribute to disparities, with residents of deprived areas facing higher exposure to carcinogens and limited access to specialized care facilities.

The impact of SDOH extends beyond clinical outcomes, significantly affecting patients' quality of life and overall well-being. Financial outcomes from cancer treatment can exacerbate existing socioeconomic challenges, creating a cycle of disadvantage. Additionally, SDOH influence patient-centered outcomes, such as treatment adherence, symptom management, and psychosocial well-being. Patients from marginalized communities often experience greater stress and reduced social support, which can negatively impact their cancer journey from diagnosis through to survivorship.

Despite extensive research, significant knowledge gaps persist in understanding the complex relationship between SDOH and cancer care. Important areas that remain underexplored include the bidirectional relationship between cancer care and socioeconomic status, and the emerging field of stress genomics in oncology. The impact of transportation barriers on cancer care continuity and outcomes represents another critical, yet understudied, area. Additionally, the influence of SDOH on cancer biology, long-term survivorship, and patient-reported outcomes requires further investigation. Understanding these complex interactions is crucial for developing effective interventions to address cancer care disparities.

This Special Issue will highlight the multifaceted impact of SDOH on cancer care, from prevention and diagnosis to treatment outcomes and survivorship.

Dr. Mohamad El Moheb
Guest Editor

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