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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Amino Acids and Their Metabolism in Disease

edited by

Toshiyuki Kitoh

submission deadline 31 Mar 2026 | Viewed by 105 | Submission Open

Keywords: amino acid metabolism; disease pathophysiology; cancer metabolism; immunometabolism; metabolic reprogramming; amino acid transporters; therapeutic targeting; biomarkers; nutrient sensing; systems biology

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

SAM Domains in Health and Diseases: Structural and Functional Insights

edited by

Flavia Anna Mercurio

and

Marilisa Leone

submission deadline 31 Mar 2026 | Viewed by 101 | Submission Open

Keywords: SAM domains; oligomer- and polymer-forming SAM; mid-loop/end-helix architecture of binding; SAM physiological and pathological signaling pathways; SAM domains as drug targets

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Choline and Its Supplementation in Human Health and Disease

edited by

Francesco Amenta

and Enea Traini

submission deadline 31 Mar 2026 | Viewed by 88 | Submission Open

Keywords: choline; transporters; deficiencies; supplementations

(This special issue belongs to the Section Molecular Medicine)

Fibronectin, Integrins and Related Molecules in Health and Diseases

edited by

Yoshikazu Takada

submission deadline 31 Mar 2026 | Viewed by 86 | Submission Open

Keywords: integrin; fibronectin; cytokines

(This special issue belongs to the Section Chemical Biology)

Citrin Deficiency: Molecular Pathogenesis and Novel Targets for Therapy

edited by

Takeyori Saheki

submission deadline 31 Mar 2026 | Viewed by 83 | Submission Open

Keywords: citrin deficiency; pathogenesis; therapeutic procedures

(This special issue belongs to the Section Molecular Medicine)

From Molecular Mechanisms to Therapies: Advances in Retinal Disease Research

edited by

Marco Feligioni

and

Maccarone Rita

submission deadline 31 Mar 2026 | Viewed by 79 | Submission Open

Keywords: retinal diseases; retinal pathologies; preclinical studies

(This special issue belongs to the Section Molecular Biology)

Synthetic Biology's Potential to Address Undruggable Targets and Difficult-to-Treat Diseases

edited by

Dario Mizrachi

submission deadline 31 Mar 2026 | Viewed by 78 | Submission Open

Keywords: synthetic biology; protein engineering; drug development; biologics; undruggable targets

(This special issue belongs to the Section Molecular Medicine)

Molecular and Cellular Mechanisms of Therapy Resistance in Acute Myeloid Leukemia

edited by

Yong-Mi Kim

submission deadline 31 Mar 2026 | Viewed by 70 | Submission Open

Keywords: acute myeloid leukemia; molecular mechanism; cellular mechanism; therapy resistance; microenvironment

(This special issue belongs to the Section Cellular Biochemistry)

Mitochondrial Calcium Signaling in Cardiac Health and Disease

edited by Enrique Balderas

submission deadline 2 Apr 2026 | Viewed by 68 | Submission Open

Keywords: mitochondrial Ca2+; OXPHOS; H+ gradient; ATP-synthesis; NAD(H) balance; Ca2+-overload; mitochondrial permeability; apoptosis; mtDNA; ROS production-clearance

(This special issue belongs to the Section Cellular Biochemistry)

The Urokinase System in Cancer: From Stress Responses to Therapeutic Targeting

edited by

Maja Matulić

and

Petra Korać

submission deadline 3 Apr 2026 | 1 articles | Viewed by 1472 | Submission Open

Keywords: urokinase plasminogen activator; PAI1; urokinase plasminogen activator receptor; transcription; regulation; cancer; migration; invasion; stress

DNA Damage and Repair in Cancer Treatment

edited by

Alexandros Georgakilas

and

Lorenzo Manti

submission deadline 15 Apr 2026 | 1 articles | Viewed by 5861 | Submission Open

Keywords: ionizing radiation; DNA damage; DNA repair; genomic instability; patient radioprotection; tumour radiosensitization; radiation-induced carcinogenesis

(This special issue belongs to the Section Molecular Biology)

Extracellular Vesicles as Biomarkers of Diseases: 2nd Edition

edited by

Mebarek Saida

and

Leyre Brizuela

submission deadline 15 Apr 2026 | Viewed by 22 | Submission Open

Keywords: extracellular vesicles; metabolic syndrome; cancer; cardiovascular diseases; neurodegenerative diseases; biomarkers

(This special issue belongs to the Section Molecular Biomarkers)

Molecular Aspects of Diseases Origin and Development

edited by

Natalia Kurhaluk

submission deadline 20 Apr 2026 | 7 articles | Viewed by 25301 | Submission Open

(This special issue belongs to the Section Molecular Medicine)

Novel Approaches to Harness Neuropathic Pain: Modulation of Glial Cells as a Therapeutic Strategy

edited by

Célia Duarte Cruz

and

José Tiago Costa-Pereira

submission deadline 20 Apr 2026 | Viewed by 110 | Submission Open

Keywords: neuropathic pain; neuroinflammation; descending pain modulation; glial cells; pharmacological therapies; non-pharmacological therapies; microglia; astrocytes

Recent Advances in the Role of Translation Machinery and Translational Control in the Cardiovascular System, 2nd Edition

edited by Peng Yao and

Wei Guo

submission deadline 20 Apr 2026 | Viewed by 41 | Submission Open

Keywords: translational control; translation machinery; RNA-binding protein; non-coding RNA

(This special issue belongs to the Section Molecular Genetics)

Synthetic Chemistry in Drug Discovery: Novel Compounds for Antimicrobial and Antioxidant Applications

edited by

Hawraz Ibrahim M. Amin

submission deadline 25 Apr 2026 | 3 articles | Viewed by 3033 | Submission Open

Keywords: synthetic chemistry; drug discovery; essential oils; antimicrobial activity; antiproliferative agents; antioxidant properties; bioactive molecules; structure– activity relationship; natural product derivatives; medicinal chemistry; chemical synthesis; pharmacological evaluation

(This special issue belongs to the Section Chemical Biology)

Mitochondria and Central Nervous System Disorders: 3rd Edition

edited by

Marta Zaninello

and

Camilla Bean

submission deadline 30 Apr 2026 | 6 articles | Viewed by 13999 | Submission Open

Keywords: mitochondria; metabolism; neurodegeneration; neuroinflammation; ageing; central nervous system

(This special issue belongs to the Section Molecular Biology)

Advances in Melanoma Targeted Therapy

edited by

Dmitriy Minond

submission deadline 30 Apr 2026 | 3 articles | Viewed by 10099 | Submission Open

Keywords: melanoma; drug discovery; new targets; target discovery

(This special issue belongs to the Section Molecular Medicine)

Cellular Signaling in Cancer

edited by

Avisek Majumder

, Shabana Bano and Kasturi Nayak

submission deadline 30 Apr 2026 | 4 articles | Viewed by 8124 | Submission Open

Keywords: signaling pathways; cancer; anti-cancer

(This special issue belongs to the Section Cellular Biochemistry)

Nanoparticles for Cancer Therapy: Challenges and Opportunities

edited by

Nagavendra Kommineni

and

Venkatesh Pooladanda

submission deadline 30 Apr 2026 | 2 articles | Viewed by 6917 | Submission Open

Keywords: nanoparticles; cancer; nanotheranostics; drug delivery; gene delivery

(This special issue belongs to the Section Bio-Engineered Materials)

Bioactive Compounds as Modifiers of Mitochondrial Function

edited by Mihail "Mike" Mitov

submission deadline 30 Apr 2026 | 2 articles | Viewed by 6859 | Submission Open

Keywords: natural bioactive compounds; synthesized bioactive compounds; mitochondrial function; electron transport chain (ETC); ATP production rate; oxygen consumption rate (OCR); extracellular acidification rate (ECAR)

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Biomarkers in Neurodegenerative Diseases: Shaping the Future of Diagnosis and Treatment

edited by

Martine Tétreault

and

Laura Hamilton

submission deadline 30 Apr 2026 | 5 articles | Viewed by 5989 | Submission Open

Keywords: molecular diagnostics; lipidomics; genomics; proteomics; transcriptomics

(This special issue belongs to the Section Molecular Biomarkers)

Genetics and Epigenetics of Breast Cancer

edited by

Ashakumary Lakshmikuttyamma

submission deadline 30 Apr 2026 | 2 articles | Viewed by 5911 | Submission Open

Keywords: breast cancer; genetic landscape; epigenetics; diagnostic/prognostic/predictive biomarkers

(This special issue belongs to the Section Molecular Genetics)

Neuroinflammation in Ocular Diseases: Emerging Insights into Mechanisms, Biomarkers, and Therapeutic Targets

edited by

S. Priya Narayanan

submission deadline 30 Apr 2026 | 3 articles | Viewed by 5187 | Submission Open

Keywords: neuroinflammation; vision; retina; optic nerve; neurodegeneration; inflammation; biomarker; therapeutic strategies; pharmacological treatments

(This special issue belongs to the Section Molecular Biomarkers)

Probiotics and Their Metabolites, 2nd Edition

edited by

Hary Razafindralambo

submission deadline 30 Apr 2026 | 3 articles | Viewed by 5132 | Submission Open

Keywords: probiotics; metabolites; functionality; biochemical aspects; biophysical aspects; physicochemical approach; molecular mechanism; interaction; synergy; adhesion; colonization; stability; prebiotics; postbiotics; synbiotics; viability; formulation; rational design; human health; animal health; plant health

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Molecular Mechanisms and Therapeutic Targets in Leukaemia

edited by

Sabrina Tosi

and

Denise Ragusa

submission deadline 30 Apr 2026 | 3 articles | Viewed by 4947 | Submission Open

Keywords: leukaemia; blood; genetics; genomics; chromosome

(This special issue belongs to the Section Molecular Medicine)

Roles of Alpha-1 Antitrypsin in Human Health and Disease Models

edited by

Sihong Song

submission deadline 30 Apr 2026 | 2 articles | Viewed by 4287 | Submission Open

Keywords: alpha-1 antitrypsin; serine proteinase inhibitor (SERPIN); autoimmunity; inflammation; aging; cancer

(This special issue belongs to the Section Molecular Medicine)

Genomics in Biodiversity Conservation (Vertebrates and Invertebrates)

edited by

Shantanu Kundu

and

Hyun-Woo Kim

submission deadline 30 Apr 2026 | 2 articles | Viewed by 3687 | Submission Open

Keywords: genomics; mitochondrial genome; genetic diversity; phylogenetic analyses; conservation genetics; gene arrangements; evolution

(This special issue belongs to the Section Molecular Genetics)

Molecular Mechanisms and Pathophysiology of Gliomas

edited by Fengchao Lang

submission deadline 30 Apr 2026 | 1 articles | Viewed by 3325 | Submission Open

Keywords: gliomas; cell cycle; epigenetic modifications; metabolic reprogramming; tumor microenvironment; targeted therapies

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Bioactive Compounds from Microalgae

edited by

Giuseppe Martelli

and

Rosa Paola Radice

submission deadline 30 Apr 2026 | 4 articles | Viewed by 3208 | Submission Open

Keywords: microalgae; bioactive compounds; biomolecules; innovations

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Molecular Mechanisms and Genetics of Human Disease

edited by

Rais Ahmad Ansari

and Ata Abbas

submission deadline 30 Apr 2026 | 1 articles | Viewed by 2556 | Submission Open

Keywords: genomic rearrangement; genetic diseases; molecular mechanism; recombination; gene duplication

(This special issue belongs to the Section Molecular Genetics)

Advances in Antimicrobial Peptides (AMPs)

edited by

Andrea Bosso

submission deadline 30 Apr 2026 | 1 articles | Viewed by 2281 | Submission Open

Keywords: antimicrobial peptides (AMPs); host defense peptides (HDPs); peptidomimetics; antimicrobial resistance (AMR); membrane interaction; cryptides; immunomodulation; peptide design and synthesis; biofilm inhibition; drug delivery systems

Molecular Mechanisms and Signaling Pathways in Autoimmune Diseases

edited by

Daniele Saverino

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2239 | Submission Open

Keywords: autoimmune diseases; molecular mechanisms; signaling pathways; therapeutic targets; biomarkers

(This special issue belongs to the Section Molecular Biology)

New Insights into Hormonal Control of Plant Growth and Development

edited by

Nihal Dharmasiri

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2210 | Submission Open

Keywords: plant hormones; auxins; cytokinin; gibberellins; ethylene; abscisic acid; jasmonic acid; salicylic acid; peptide hormones; growth and development

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Anti-Tumor Metal Complexes and Drug Delivery Systems: 2nd Edition

edited by Jasmina Dimitrić Marković,

Goran Kaluđerović

and

Dušan Dimić

submission deadline 30 Apr 2026 | 1 articles | Viewed by 2115 | Submission Open

Keywords: transition metal complexes; synthesis; structural characterization; biological activity; in silico methods; drug delivery

Food, Microbe, Viral and Parasite-Derived Antibodies in Autoimmune and Chronic Diseases

edited by

Phaedra Eleftheriou

submission deadline 30 Apr 2026 | 1 articles | Viewed by 2093 | Submission Open

Keywords: food antigens; antigens; auto-antigens; antibodies; auto-antibodies; auto-immune diseases; chronic diseases; microbes; bacteria; fungi; virus; parasites; cross-reaction; infection; chronic diseases

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Homocysteine and H₂S in Health and Disease, 2nd Edition

edited by

Anton Hermann

and

Guzel F. Sitdikova

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1720 | Submission Open

Keywords: homocysteine (Hcy); hydrogen sulfide (H2S); oxidative stress; inflammation

(This special issue belongs to the Section Chemical Biology)

Metallic Nanoparticles: Biosynthesis and Therapeutic Potential

edited by

Sónia Gonçalves

and

Isabelle Michaud-Soret

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1638 | Submission Open

Keywords: silver nanoparticle; antibacterial agent; green synthesis; therapeutics

(This special issue belongs to the Section Biological Factors)

Multiple Myeloma: From Pathophysiology to Novel Therapeutic Approaches

edited by

Cirino Botta

submission deadline 30 Apr 2026 | 2 articles | Viewed by 1293 | Submission Open

Keywords: multiple myeloma; tumor immunology; MGUS; sMM

The Role and Metabolism of Metals in Cancer

edited by

Anna Martina Battaglia

submission deadline 30 Apr 2026 | 1 articles | Viewed by 986 | Submission Open

Keywords: metals; cancer; cancer metabolism

(This special issue belongs to the Section Chemical Biology)

Metal-Based Complexes in Medicine: From Therapeutics to Diagnostics and Theranostics

edited by

Iogann Tolbatov

and

Andrea Melchior

submission deadline 30 Apr 2026 | 1 articles | Viewed by 851 | Submission Open

Keywords: anticancer metal complexes; antitumor metallodrugs; antimicrobial agents; antiviral metallodrugs; medicinal inorganic chemistry; bioinorganic chemistry; computational design; molecular dynamics; docking; spectroscopic methods; NMR; mechanistic studies; rational drug development; synthesis; biological evaluation; drug delivery; experimental; in vitro; in vivo; theranostics; medicinal imaging

Phytochemicals: Bioactivity in Disease Prevention, Anti-Inflammation, and Animal/Human Health

edited by

Jayasimha Rayalu Daddam

and

Kotha Peddanna

submission deadline 30 Apr 2026 | Viewed by 794 | Submission Open

Keywords: phytochemicals; anti-inflammatory; metabolic health; oxidative stress; gut microbiome; nutrigenomics; animal health; human health; systems biology; AI/ML

(This special issue belongs to the Section Molecular Medicine)

Lipids and Lipoproteins in Human Health and Disease

edited by

Menno Hoekstra

submission deadline 30 Apr 2026 | 1 articles | Viewed by 699 | Submission Open

Keywords: lipid; lipoprotein; lipophilic molecules

(This special issue belongs to the Section Biological Factors)

Biomolecular Sciences and Precision Medicine in Vascular Disease

edited by

Raffaele Serra

submission deadline 30 Apr 2026 | 1 articles | Viewed by 692 | Submission Open

Keywords: precision medicine; vascular disease; vascular surgery

(This special issue belongs to the Section Molecular Medicine)

Metabolic Syndrome and Type 2 Diabetes: From Molecular Pathogenesis to Novel Therapies

edited by

Srinivas Nammi

submission deadline 30 Apr 2026 | Viewed by 382 | Submission Open

Keywords: metabolic syndrome; type 2 diabetes; insulin resistance; molecular pathogenesis; novel therapies

(This special issue belongs to the Section Molecular Medicine)

Omics in Entomology: Unraveling the Molecular Mechanisms of Insects

edited by

Kaio Cesar Chaboli Alevi

submission deadline 30 Apr 2026 | Viewed by 306 | Submission Open

Keywords: entomology; medical entomology; forensic entomology; agricultural entomology; omics

(This special issue belongs to the Section Molecular Genetics)

Advances in S-Triazine-Based Therapeutics: From Antimicrobials to Neurodegenerative Disease Modulators

edited by

Danuta Drozdowska

submission deadline 30 Apr 2026 | Viewed by 265 | Submission Open

Keywords: 1; 3; 5-triazine; s-triazine; biological activity; drug discovery; antibacterial agent; antifungal agent; anticancer activity; antiviral agents; antimalarial activity; anti-Alzheimer’ s activity; anti-Alzheimer’ s agents; cholinesterase inhibitors; BACE1 inhibitors; anti-neurodegenerative effects; anti-inflammatory activity; molecular mechanisms of s-triazine activity

(This special issue belongs to the Section Chemical Biology)

Psilocybe Mushrooms Constituents—Therapeutic Implications

edited by

Andrea Bugarcic

and Janet Schloss

submission deadline 30 Apr 2026 | Viewed by 247 | Submission Open

Keywords: Psilocybe mushrooms; psilocybin; pre-clinical research; neurodegeneration

Cell Death and Clearance

edited by

Ivan Poon

and Jascinta Santavanond

submission deadline 30 Apr 2026 | Viewed by 212 | Submission Open

Keywords: cell death; apoptosis; efferocytosis; cell clearance

(This special issue belongs to the Section Molecular Medicine)

Enzyme Inhibitors as Novel Medicinal Agents: From Current to Future Applications

edited by George Kokotos and

Christiana Mantzourani

submission deadline 30 Apr 2026 | Viewed by 192 | Submission Open

Keywords: design and synthesis of inhibitors; structure-activity relationship studies; inhibitors of histone deacetylases; inhibitors of proteases; inhibitors of kinases; inhibitors of lipid hydrolyzing enzymes; inhibitors of viral enzymes

(This special issue belongs to the Section Molecular Medicine)

Displaying special issue 251-300 on page 6 of 11.

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