Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Bionanomaterials: Synthesis, Characterization, Toxicity and Biomedical Applications, 3rd Edition submission deadline 30 Sep 2025 | Viewed by 75 | Submission Open
Keywords: nanoparticles; nano-alloys; graphene; nanotubes; hybrid nanomaterials; green synthesis; cytotoxicity; systemic toxicity; modulation of the biological impact; nanomaterials as diagnostic and therapeutic platforms; potential applications in medicine
(This special issue belongs to the Section Bio-Engineered Materials)
Cellular Signaling and Cardiovascular Diseases: From NF-κB to Golgi Dynamics
edited by
submission deadline 30 Sep 2025 | Viewed by 73 | Submission Open
Keywords: cardiovascular diseases; NF-κ B signaling; vascular cells; epigenetic regulation; vascular inflammation; intercellular crosstalk; Golgi dynamics  
(This special issue belongs to the Section Cellular Biochemistry)
Cell Death and Clearance
edited by and Jascinta Santavanond
submission deadline 30 Sep 2025 | Viewed by 73 | Submission Open
Keywords: cell death; apoptosis; efferocytosis; cell clearance
(This special issue belongs to the Section Molecular Medicine)
Epigenetic Regulation of Vascular Smooth Muscle Cells During Development and Disease submission deadline 30 Sep 2025 | Viewed by 67 | Submission Open
Keywords: vascular smooth muscle cells; cell phenotypic change; epigenetics; gene expression regulation; cell differentiation
(This special issue belongs to the Section Molecular Biology)
New Insights into Hormonal Control of Plant Growth and Development
edited by
submission deadline 30 Sep 2025 | Viewed by 67 | Submission Open
Keywords: plant hormones; auxins; cytokinin; gibberellins; ethylene; abscisic acid; jasmonic acid; salicylic acid; peptide hormones; growth and development
(This special issue belongs to the Section Molecular Biology)
T Cell Ca2+ Signal Dynamics: An Emerging Landscape for Therapeutic Strategies
edited by David W. Thomas and
submission deadline 30 Sep 2025 | Viewed by 62 | Submission Open
Keywords: T cell signaling; Ca signaling; TCR-activated signals; ER Ca release; ER Ca stores; store-operated Ca influx; ER Ca store depletion signals
(This special issue belongs to the Section Cellular Biochemistry)
Metallic Nanoparticles: Biosynthesis and Therapeutic Potential submission deadline 30 Sep 2025 | Viewed by 56 | Submission Open
Keywords: silver nanoparticle; antibacterial agent; green synthesis; therapeutics
(This special issue belongs to the Section Biological Factors)
Cancer Epigenetics, Post-Translational Modification, and Drug Discovery
edited by
submission deadline 30 Sep 2025 | Viewed by 55 | Submission Open
Keywords: cancer; drug Discovery; epigenetics; inflammation; NF– κ B
(This special issue belongs to the Section Cellular Biochemistry)
Advances in Microbial CRISPR Editing
edited by and Rongming Liu
submission deadline 30 Sep 2025 | Viewed by 55 | Submission Open
Keywords: CRISPR-Cas; microbial genome editing; synthetic biology; base and prime editing; multiplexed CRISPR engineering; microbiome manipulation; phage and plasmid control; evolutionary stability of CRISPR edits; CRISPR-driven biocontainment; novel CRISPR systems
(This special issue belongs to the Section Molecular Biology)
Psilocybe Mushrooms Constituents—Therapeutic Implications
edited by and Janet Schloss
submission deadline 30 Sep 2025 | Viewed by 50 | Submission Open
Keywords: Psilocybe mushrooms; psilocybin; pre-clinical research; neurodegeneration
Molecular Mechanisms and Genetics of Human Disease
edited by and Ata Abbas
submission deadline 30 Sep 2025 | Viewed by 49 | Submission Open
Keywords: genomic rearrangement; genetic diseases; molecular mechanism; recombination; gene duplication
Unraveling the Mysteries of Muscle: Advances in Myogenesis, Physiology, and Wasting Disorders
edited by
submission deadline 30 Sep 2025 | Viewed by 43 | Submission Open
Keywords: muscle biology; molecular mechanism; myogenesis; muscle physiology; muscle wasting; sarcopenia; cachexia; muscle-related pathologies
The Role and Metabolism of Metals in Cancer submission deadline 30 Sep 2025 | Viewed by 38 | Submission Open
Keywords: metals; cancer; cancer metabolism
Molecular Mechanisms of Human Skin Aging
edited by
submission deadline 15 Oct 2025 | 4 articles | Viewed by 10851 | Submission Open
Keywords: skin aging; UV; extracellular matrix; fibroblast; prevention
(This special issue belongs to the Section Molecular Medicine)
Regulation of Synapses in the Brain
edited by and Guohao Wang
submission deadline 15 Oct 2025 | Viewed by 71 | Submission Open
Keywords: synaptic plasticity; neurodevelopmental disorders; glial cells; synaptic formation; learning and memory; neuroinflammation; neurodegenerative diseases; extracellular matrix; synaptic dysfunction; therapeutic interventions
Mechanisms of RNA Regulation in Inflammation
edited by
submission deadline 15 Oct 2025 | Viewed by 34 | Submission Open
Keywords: inflammation; inflammatory diseases; non-coding RNAs; microRNAs (miRNAs); circular RNAs; biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Genetics)
Synthetic Chemistry in Drug Discovery: Novel Compounds for Antimicrobial and Antioxidant Applications submission deadline 16 Oct 2025 | Viewed by 38 | Submission Open
Keywords: synthetic chemistry; drug discovery; essential oils; antimicrobial activity; antiproliferative agents; antioxidant properties; bioactive molecules; structure– activity relationship; natural product derivatives; medicinal chemistry; chemical synthesis; pharmacological evaluation
Molecular Biomarkers of Epileptogenesis
edited by Pedro J. Serrano-Castro
submission deadline 20 Oct 2025 | 2 articles | Viewed by 2895 | Submission Open
Keywords: epileptogenesis; neuroinflammation; biomarkers; drug-resistant epilepsy; personalized neurology
(This special issue belongs to the Section Molecular Biomarkers)
The Urokinase System in Cancer: From Stress Responses to Therapeutic Targeting
edited by and
submission deadline 22 Oct 2025 | Viewed by 34 | Submission Open
Keywords: urokinase plasminogen activator; PAI1; urokinase plasminogen activator receptor; transcription; regulation; cancer; migration; invasion; stress
Antituberculous Drugs: Progress and Challenges
edited by and Ana Maria Telmo Dias Pereira Vicente Cabral
submission deadline 25 Oct 2025 | Viewed by 32 | Submission Open
Keywords: antituberculostatic drugs; carriers; bioavailability; delivery systems
Molecular and Cellular Mechanisms in Skin Disorders
edited by
submission deadline 30 Oct 2025 | Viewed by 180 | Submission Open
Keywords: inflammatory skin disease; psoriasis; atopic dermatitis; cytokine; comorbidity; complication; systemic inflammation; internal organ
(This special issue belongs to the Section Molecular Biology)
In Silico Drug Design and Discovery: Big Data for Small Molecule Design 2nd Edition submission deadline 31 Oct 2025 | 5 articles | Viewed by 11697 | Submission Open
Keywords: drug discovery; medicinal chemistry; chemoinformatics; bioinformatics; machine learning; deep learning
(This special issue belongs to the Section Bioinformatics and Systems Biology)
Advances in Cellular Biophysics: Transport and Mechanics
edited by Boris Musset and
submission deadline 31 Oct 2025 | 4 articles | Viewed by 6046 | Submission Open
Keywords: membrane transport; ion transport; cellular biophysics; applied science; basic science
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Advances in Cellular and Molecular Mechanisms in Immuno-Oncology and Onco-Hematology
edited by
submission deadline 31 Oct 2025 | 4 articles | Viewed by 5644 | Submission Open
Keywords: cancer immunotherapy; inhibitory immune checkpoints; CAR T cells; tumor immune evasion; cancer target therapy
(This special issue belongs to the Section Cellular Biochemistry)
Liver Damage and Associated Metabolic Disorders
edited by
submission deadline 31 Oct 2025 | 4 articles | Viewed by 5433 | Submission Open
Keywords: lipid species; lipid metabolism; organelle dynamics; hepatokines; metabolic risk; immune responses
(This special issue belongs to the Section Molecular Medicine)
New Insights into the Membranes of Anoxygenic Phototrophic Bacteria submission deadline 31 Oct 2025 | 3 articles | Viewed by 4453 | Submission Open
Keywords: anoxygenic phototrophs; light harvesting; membrane dynamics; molecular evolution; reaction centers
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Application of Bioinformatics in Medicine
edited by
submission deadline 31 Oct 2025 | 3 articles | Viewed by 4108 | Submission Open
Keywords: computer-aided drug design (CADD); bioinformatics; systems medicine; drug discovery; computational biology
(This special issue belongs to the Section Bioinformatics and Systems Biology)
Biomolecules and Materials Based Approaches in Biomedical Field: 2nd Edition submission deadline 31 Oct 2025 | 3 articles | Viewed by 3927 | Submission Open
Keywords: biomolecules roles in biological processes and pathologies; therapeutic molecules; biomarkers; biomolecules for disease diagnostics; and pharmaceutical development; cell signaling biomolecules; biomaterials for biomedical applications; self-assembled biomaterials; biofunctionalization of materials; new fabrication technologies (e.g.; 3D printing); biosensors for disease diagnostics and/or prognosis; 3D scaffolds and hydrogels; 3D material-based tissue models; membrane bioreactors; bioartificial organs; materials for cell-/drug-delivery systems; in vitro material platforms for disease modeling/drug screening; materials for fabricating microfluidic systems
(This special issue belongs to the Section Molecular Medicine)
Molecular and Genetic Basis of Neurodegenerative Diseases
edited by Teresa M. Gunn and Andrea Grindeland
submission deadline 31 Oct 2025 | 5 articles | Viewed by 3785 | Submission Open
Keywords: neurodegeneration; neurodegenerative diseases; protein misfolding; protein trafficking; mitochondrial dysfunction; oxidative stress; neuronal homeostasis; neuroinflammation
(This special issue belongs to the Section Molecular Genetics)
Nonalcoholic Fatty Liver Disease: From Molecular Mechanisms to Therapeutic Approaches
edited by and
submission deadline 31 Oct 2025 | 3 articles | Viewed by 3078 | Submission Open
Keywords: nonalcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis (NASH); reactive oxygen species; mitochondria; lipotoxicity
(This special issue belongs to the Section Molecular Medicine)
Molecular and Cellular Mechanisms of Kidney Diseases
edited by and Maria Divani
submission deadline 31 Oct 2025 | 1 articles | Viewed by 1602 | Submission Open
Keywords: chronic kidney disease; acute kidney injury; kidney transplantation; glomerular diseases; ischemia– reperfusion injury; diabetic nephropathy
(This special issue belongs to the Section Molecular Biology)
Nanoparticles for Cancer Therapy: Challenges and Opportunities submission deadline 31 Oct 2025 | 1 articles | Viewed by 1515 | Submission Open
Keywords: nanoparticles; cancer; nanotheranostics; drug delivery; gene delivery
(This special issue belongs to the Section Bio-Engineered Materials)
Inflammation and Hemostasis: 2nd Edition
edited by
submission deadline 31 Oct 2025 | 1 articles | Viewed by 998 | Submission Open
(This special issue belongs to the Section Molecular Medicine)
Cutting-Edge Perspectives on Protein and Enzyme Engineering
edited by Haishan Qi and Haoran Yu
submission deadline 31 Oct 2025 | 1 articles | Viewed by 912 | Submission Open
Keywords: protein engineering; protein material; enzyme evolution; therapy protein; protein expression; machine learning; unnatural amino acids
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Crosstalk Between the Immune and Nervous Systems
edited by
submission deadline 31 Oct 2025 | 1 articles | Viewed by 891 | Submission Open
Keywords: microglia; astrocytes; macrophages; cerebral blood vessels; cerebrospinal fluid (CSF); meninges; immune cells; neuroinflammation; neurodegenerative disorders; psychiatric disorders
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Molecular Genetics of Bacteria
edited by Bin Jia
submission deadline 31 Oct 2025 | 1 articles | Viewed by 771 | Submission Open
Keywords: bacterial gene regulation; CRISPR-Cas systems; bacterial resistance; microbial genomics; genome-wide association studies; bacterial pathogenesis; genetic diversity
(This special issue belongs to the Section Molecular Genetics)
Homocysteine and H2S in Health and Disease, 2nd Edition submission deadline 31 Oct 2025 | 1 articles | Viewed by 699 | Submission Open
Keywords: homocysteine (Hcy); hydrogen sulfide (H2S); oxidative stress; inflammation
(This special issue belongs to the Section Chemical Biology)
Involved Biomolecules Within Lysosomal Energy Sensing in Health and Disease
edited by Xianrui Yang and
submission deadline 31 Oct 2025 | Viewed by 529 | Submission Open
Keywords: lysosomal energy sensing; vacuolar H+-ATPase (V-ATPase); 5’ -AMP-activated kinase (AMPK); mammalian target of rapamycin (mTor); sirtuin; aldolase; TRPV1; metformin; rapamycin
The Biomarkers in Renal Diseases
edited by and María Carmen Ruiz Fuentes
submission deadline 31 Oct 2025 | 1 articles | Viewed by 516 | Submission Open
Keywords: biomarkers; acute kidney injury; chronic kidney disease; microvesicles; exosomes
(This special issue belongs to the Section Molecular Biomarkers)
Genetics and Epigenetics of Breast Cancer submission deadline 31 Oct 2025 | 1 articles | Viewed by 445 | Submission Open
Keywords: breast cancer; genetic landscape; epigenetics; diagnostic/prognostic/predictive biomarkers
(This special issue belongs to the Section Molecular Genetics)
DNA Damage Repair and Cancer Therapeutics
edited by
submission deadline 31 Oct 2025 | 1 articles | Viewed by 432 | Submission Open
Keywords: DNA damage repair; cancer therapy; genomic stability; targeted therapy; biomarkers
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Applications of Biomaterials in Medicine and Healthcare submission deadline 31 Oct 2025 | 1 articles | Viewed by 363 | Submission Open
Keywords: biomaterials; tissue engineering; biomedical applications; drug delivery systems; medical implants
Food, Microbe, Viral and Parasite-Derived Antibodies in Autoimmune and Chronic Diseases submission deadline 31 Oct 2025 | Viewed by 309 | Submission Open
Keywords: food antigens; antigens; auto-antigens; antibodies; auto-antibodies; auto-immune diseases; chronic diseases; microbes; bacteria; fungi; virus; parasites; cross-reaction; infection; chronic diseases
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Immune Response to Allergens submission deadline 31 Oct 2025 | Viewed by 305 | Submission Open
Keywords: allergy; immune response; allergen; sensitization; molecular allergology; diagnostics; specific immunotherapy
(This special issue belongs to the Section Cellular Biochemistry)
Studies of Protein Dynamics Using Fluorescence Correlation Spectroscopy (FCS)
edited by Jieqiong Lou and Elvis Pandžić
submission deadline 31 Oct 2025 | Viewed by 285 | Submission Open
Keywords: protein dynamics; Fluorescence Correlation Spectroscopy (FCS); protein interactions; subcellular environments; Image Correlation Spectroscopy(ICS) and extensions
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Molecular Mechanism and Regulation of Adipogenesis, Adipose Tissue Inflammation and Metabolism
edited by Udai P Singh
submission deadline 31 Oct 2025 | Viewed by 164 | Submission Open
Keywords: immunometabolism; obesity; adipogenesis; adipose tissue inflammation; adipose immune microenvironment; immune-adipose tissue cross-talk; hormones; high-fat diet; metabolic disease
(This special issue belongs to the Section Biological Factors)
Biochemistry and Molecular Biology of Vitamin D and Its Analog, 3rd Edition
edited by and Naoko Tsugawa
submission deadline 31 Oct 2025 | Viewed by 136 | Submission Open
Keywords: vitamin D; vitamin D receptor; vitamin D analog; genomic action; non-genomic action; bone formation; immune response; cancer; rickets; osteoporosis; psoriasis; drug discovery; disease prevention; nutrition improvement metabolism of vitamin D or its analogs cytochrome P450
Assembly of RNA and DNA
edited by and
submission deadline 31 Oct 2025 | Viewed by 104 | Submission Open
Keywords: polymerization of RNA and DNA; electrical functioning of RNA/DNA; rotational– electric principles of replication; interactions between RNA/DNA and physical/chemical field; chirality in biomolecules
(This special issue belongs to the Section Molecular Genetics)
Advancing Innovations in Biomedical Research for Translational Applications
edited by Jianjie Ma, Ki Ho Park and
submission deadline 31 Oct 2025 | Viewed by 71 | Submission Open
Keywords: nanoparticle drug delivery; precision medicine; stem cell; proteomic and lipidomic profiling; novel therapeutic strategies; regenerative medicine; biologic drug development; IND submission
Advances in Metabolomics in Health and Disease
edited by
submission deadline 31 Oct 2025 | Viewed by 63 | Submission Open
Keywords: metabolomics; disease biomarkers; metabolic phenotyping; metabolic pathways; mass spectrometry; NMR spectroscopy; metabolic databases; bioinformatics
(This special issue belongs to the Section Molecular Medicine)
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