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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Bioactive Molecules in the Control of Oxidative Stress and Oxidative Stress-Related Diseases

edited by

Jian Yao

submission deadline 31 May 2026 | 2 articles | Viewed by 6107 | Submission Open

Keywords: antioxidants; bioactive molecules; ROS; redox signaling; oxidative stress-related diseases

(This special issue belongs to the Section Molecular Medicine)

Biomarkers of Cardiovascular and Cerebrovascular Diseases, 2nd Edition

edited by

Ana Catarina Fonseca

submission deadline 31 May 2026 | 4 articles | Viewed by 5637 | Submission Open

Keywords: biomarkers; cardiovascular disease; cerebrovascular disease; cardiovascular therapy; diagnosis

(This special issue belongs to the Section Molecular Biomarkers)

Calcium Signaling and Transport in Health and Disease: Recent Developments and New Insights

edited by

Mykola Mamenko

and Brandi M. Wynne

submission deadline 31 May 2026 | 3 articles | Viewed by 5104 | Submission Open

Keywords: calcium signaling; calcium transport; calcium channel; calbindin; calcium pump; calcium stores; mitochondrial calcium; store-operated calcium entry; calcium release

(This special issue belongs to the Section Cellular Biochemistry)

Advancing Innovations in Biomedical Research for Translational Applications

edited by Jianjie Ma, Ki Ho Park and

Zui Pan

submission deadline 31 May 2026 | 3 articles | Viewed by 4910 | Submission Open

Keywords: nanoparticle drug delivery; precision medicine; stem cell; proteomic and lipidomic profiling; novel therapeutic strategies; regenerative medicine; biologic drug development; IND submission

(This special issue belongs to the Section Molecular Medicine)

Recent Advances in RNA Editing and Modification

edited by

Toshifumi Tsukahara

submission deadline 31 May 2026 | 2 articles | Viewed by 4781 | Submission Open

Keywords: RNA editing; RNA modification; deamination; transamination; pseudouridylation

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Protein Biophysics

edited by

Vladimir N. Uversky

and

Orkid Coskuner-Weber

submission deadline 31 May 2026 | 4 articles | Viewed by 4618 | Submission Open

Keywords: protein function; protein folding; protein misfolding; protein structure; protein dynamics; protein stability; protein and peptide aggregation; posttranslational modifications; intrinsically disordered proteins; protein– ligand interactions; protein– protein interactions; protein– nucleic acid interactions; membrane proteins; liquid– liquid phase separation

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Molecular and Cellular Mechanisms in Skin Disorders

edited by

Keiichi Yamanaka

submission deadline 31 May 2026 | 2 articles | Viewed by 3581 | Submission Open

Keywords: inflammatory skin disease; psoriasis; atopic dermatitis; cytokine; comorbidity; complication; systemic inflammation; internal organ

(This special issue belongs to the Section Molecular Biology)

Advances in Metabolomics in Health and Disease

edited by

Carmen Socaciu

submission deadline 31 May 2026 | 2 articles | Viewed by 2774 | Submission Open

Keywords: metabolomics; disease biomarkers; metabolic phenotyping; metabolic pathways; mass spectrometry; NMR spectroscopy; metabolic databases; bioinformatics

(This special issue belongs to the Section Molecular Medicine)

Cutting-Edge Perspectives on Protein and Enzyme Engineering

edited by Haishan Qi and Haoran Yu

submission deadline 31 May 2026 | 1 articles | Viewed by 1912 | Submission Open

Keywords: protein engineering; protein material; enzyme evolution; therapy protein; protein expression; machine learning; unnatural amino acids

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

DNA Damage Repair and Cancer Therapeutics

edited by

Wenjing Li

submission deadline 31 May 2026 | 2 articles | Viewed by 1824 | Submission Open

Keywords: DNA damage repair; cancer therapy; genomic stability; targeted therapy; biomarkers

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Obesity, Hormones and Reproductive Health

edited by

Srinivas Nammi

submission deadline 31 May 2026 | 1 articles | Viewed by 1755 | Submission Open

Keywords: obesity; leptin; insulin; estrogens; androgens; growth hormone; sexual dysfunction; reproductive health

(This special issue belongs to the Section Biological Factors)

Molecular Mechanisms and Therapeutic Strategies for Metabolic Dysfunction: From Molecules to Population Health

edited by

Zhipeng Liu

submission deadline 31 May 2026 | 2 articles | Viewed by 1751 | Submission Open

Keywords: metabolic dysfunction; molecular mechanisms; therapeutic strategies; genomics; genetic epidemiology; comorbidities; biomarkers

Acute Kidney Injury and Mitochondrial Involvement

edited by

Iva Suman

and Alenka Višnić

submission deadline 31 May 2026 | 1 articles | Viewed by 1697 | Submission Open

Keywords: acute kidney injury; mitochondrial dysfunction; mitochondrial dynamics; mitophagy; biomarkers

(This special issue belongs to the Section Chemical Biology)

Identifying New Therapeutic Targets for Psychiatric Disease Using Transcriptomics and Epigenomics

edited by

Dennis R. Grayson

and

Jacob Peedicayil

submission deadline 31 May 2026 | 1 articles | Viewed by 1497 | Submission Open

Keywords: epigenomics; psychiatric disease; psychiatry; therapeutic target; transcriptomics

(This special issue belongs to the Section Molecular Genetics)

Impact of Systemic Inflammation on Neuroinflammation, Neurodegenerative Diseases and Mental Disorders

edited by

Raymond Chuen-Chung Chang

submission deadline 31 May 2026 | 1 articles | Viewed by 1400 | Submission Open

Keywords: systemic inflammation; neuroinflammation diseases; neurodegenerative diseases; mental disorders

(This special issue belongs to the Section Molecular Medicine)

Advances in Microbial CRISPR Editing

edited by

Dongdong Yang

and Rongming Liu

submission deadline 31 May 2026 | 1 articles | Viewed by 1233 | Submission Open

Keywords: CRISPR-Cas; microbial genome editing; synthetic biology; base and prime editing; multiplexed CRISPR engineering; microbiome manipulation; phage and plasmid control; evolutionary stability of CRISPR edits; CRISPR-driven biocontainment; novel CRISPR systems

(This special issue belongs to the Section Molecular Biology)

Dysregulated Cytokine Signals in Human Disease

edited by

Alister C. Ward

submission deadline 31 May 2026 | 1 articles | Viewed by 1098 | Submission Open

Keywords: cytokine; signaling; dysregulation; immunity; development; disease

(This special issue belongs to the Section Molecular Medicine)

Advances in Membrane Proteins: From Structure to Function and Molecular Engineering

edited by

Ximin Chi

and Renhong Yan

submission deadline 31 May 2026 | 1 articles | Viewed by 799 | Submission Open

Keywords: membrane transport; transmembrane signaling; membrane protein complex; membrane-based reactions; membrane and protein interaction; regulation of membrane proteins; membrane protein design; membrane protein engineering

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

New Insight into the Structures and Host Cell Interactions of Emerging Viruses

edited by

Wei Zhang

and

Qibin Geng

submission deadline 31 May 2026 | 1 articles | Viewed by 588 | Submission Open

Keywords: emerging viruses; virus structure; structural biology; Cryo-EM/Cryo-ET/CLEM; virus– host interactions; viral receptor binding and entry; viral assembly; maturation; and egress; immune evasion; molecular dynamics simulation; antiviral targets

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Pediatric Epilepsy: Insights from Genetics to Mechanisms

edited by Denise Drongitis and

Maria Giuseppina Miano

submission deadline 31 May 2026 | Viewed by 449 | Submission Open

Keywords: integrative omics; organoid models; brain development; PE-related pathways; innovative therapeutic approaches

(This special issue belongs to the Section Molecular Genetics)

Bench and Bedside: Molecular Insights and Neuroprotective Strategies for Stroke

edited by

Yuchuan Ding

submission deadline 31 May 2026 | Viewed by 412 | Submission Open

Keywords: neuroprotection; neurorehabilitation; conditioning medicine; ischemia and reperfusion injury; cerebral hemor-rhages; stress; vascular diseases

(This special issue belongs to the Section Molecular Medicine)

Assembly of RNA and DNA

edited by

Roman Marks

and

Jürg Bähler

submission deadline 31 May 2026 | Viewed by 262 | Submission Open

Keywords: polymerization of RNA and DNA; electrical functioning of RNA/DNA; rotational– electric principles of replication; interactions between RNA/DNA and physical/chemical field; chirality in biomolecules

(This special issue belongs to the Section Molecular Genetics)

Metabolic and Signal Transduction Pathways Controlling Platelet and Megakaryocyte Activity

edited by Ana Kasirer-Friede and Deepa Gautam

submission deadline 31 May 2026 | Viewed by 252 | Submission Open

Keywords: platelet; megakaryocyte; signaling; omics; immune

(This special issue belongs to the Section Molecular Biology)

Botanic Metabolites: From Extraction to Application

edited by

Carmen Formisano

submission deadline 31 May 2026 | Viewed by 209 | Submission Open

Keywords: medicinal plants; phytochemistry; antimicrobial activity; plant extracts; essential oils; synergism

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Molecular Basis and Translational Research in Metabolic Myopathies: A Themed Issue in Honor of Professor Corrado Angelini, 2nd Edition

edited by

Marija Meznaric

Daniela Tavian

and

Sara Missaglia

submission deadline 31 May 2026 | Viewed by 184 | Submission Open

Keywords: metabolic myopathies; lipid metabolism; glycogen metabolism; genetic diseases; treatments; lipid storage myopathies; glycogen storage myopathies; lysosomal storage myopathies

(This special issue belongs to the Section Molecular Biology)

The Role of Amyloid in Neurological Disorders: 2nd Edition

edited by

Marny Fedrigo

and Tamara Berno

submission deadline 31 May 2026 | Viewed by 168 | Submission Open

Keywords: amyloid-beta; neurodegenerative disorders; aducanumab; oligomers; cross-amyloid interaction

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Artificial Intelligence in Structural Biology and Drug Discovery

edited by Kyle Biggar

submission deadline 31 May 2026 | Viewed by 131 | Submission Open

Keywords: protein structure prediction; drug discovery; molecular docking; experimental validation

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Symbiotic Systems and Viral Diversity: From Marine Organisms to Human Pathogenesis

edited by

Padmanabhan Mahadevan

submission deadline 31 May 2026 | Viewed by 118 | Submission Open

Keywords: viral diversity; virome; symbiosis; genomics; pathogenesis; metagenomics; sequencing

Immune Microenvironment in Cancer: Myeloid Cells and Therapeutic Insights

edited by

Daniëlle Krijgsman

submission deadline 31 May 2026 | Viewed by 115 | Submission Open

Keywords: cancer; immunotherapy; myeloid cells; macrophages; neutrophils; tumor microenvironment; therapy resistance

(This special issue belongs to the Section Molecular Medicine)

Advances and Emerging Strategies in Gene Therapy

edited by Xin Chen

submission deadline 31 May 2026 | Viewed by 100 | Submission Open

Keywords: AAV; gene-editing; base editing; prime editing; RNA editing; lipid nanoparticles; liposomes; exosomes; tRNA therapy; small activating RNAs

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms of Viral Infections—2nd Edition

edited by

Ioannis Karakasiliotis

Christine Kottaridi

and

Konstantinos Konstantinidis

submission deadline 31 May 2026 | Viewed by 99 | Submission Open

Keywords: viral replication; virus evolution; immune response; antiviral strategies virus; infection; pathogenesis; virulence

(This special issue belongs to the Section Molecular Biology)

Molecular Engineering and Applications of Protein Cages and Cavities

edited by

John F. Honek

submission deadline 31 May 2026 | Viewed by 97 | Submission Open

Keywords: host-guest encapsulation; drug targeting; virus-like nanoparticles; ferritins; cavity-containing biomolecules; vault proteins; encapsulins; nanocompartments; medicinal; materials science; and analytical applications

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Innate Immunity and Inflammation: From Molecular Mechanisms to Therapeutic Applications

edited by

Simona Pergolizzi

and Anthea Miller

submission deadline 31 May 2026 | Viewed by 92 | Submission Open

Keywords: inflammation; innate immunity; therapeutic targets; immune signaling pathways; pattern-recognition receptors (PRRs)

(This special issue belongs to the Section Molecular Medicine)

Molecular Diagnostics and Targeted Therapies for Breast and Prostate Cancers

edited by

Anna Orlova

, Ekaterina Bezverkhniaia and Panagiotis Kanellopoulos

submission deadline 31 May 2026 | Viewed by 83 | Submission Open

Keywords: molecular imaging; targeted therapy; prostate cancer; breast cancer; theranostics

(This special issue belongs to the Section Biological Factors)

Genomic Instability: Insights into Molecular Mechanisms, Human Diseases, and Therapies

edited by

Dong Zhang

submission deadline 31 May 2026 | Viewed by 72 | Submission Open

Keywords: genome instability; DNA damage response; cancer; therapy; diagnosis

(This special issue belongs to the Section Molecular Genetics)

Molecular Mechanisms of Oocyte and Early Embryo Development: RNA Regulation and Epigenetic Modifications

edited by

Heng-Yu Fan

and

Xing‐Xing Dai

submission deadline 31 May 2026 | Viewed by 66 | Submission Open

Keywords: oocyte; embryo development; follicular development; RNA regulation; epigenetic modifications

(This special issue belongs to the Section Molecular Reproduction)

Molecular Research on Autoimmune Diseases: From Diagnosis to Therapy

edited by

Serena Guiducci

submission deadline 31 May 2026 | Viewed by 64 | Submission Open

Keywords: systemic sclerosis; autoimmune diseases; rheumatic diseases; chronic inflammation; mechanisms

(This special issue belongs to the Section Biological Factors)

Skin Diseases: Molecular Pathogenesis and Therapeutic Approaches

edited by Georgios Gaitanis,

Ioannis D. Bassukas

and Achilleas Floudas

submission deadline 31 May 2026 | Viewed by 55 | Submission Open

Keywords: skin; pathophysiology; immunology; biochemistry; omics

(This special issue belongs to the Section Molecular Medicine)

Cellular Stress, Inflammation, and Metabolic Dysfunction in the Progression of MASLD

edited by Weber Andre Alberto

submission deadline 31 May 2026 | Viewed by 52 | Submission Open

Keywords: MASLD; fibrosis; liver; hepatosteatosis; endoplasmic reticulum stress

(This special issue belongs to the Section Molecular Medicine)

Molecular Docking and Dynamics in Drug Discovery

edited by

Črtomir Podlipnik

submission deadline 31 May 2026 | Viewed by 52 | Submission Open

Keywords: molecular docking; molecular dynamics (MD); structure-based drug design (SBDD); computational drug discovery; open science

(This special issue belongs to the Section Chemical Biology)

Nitric Oxide and Reactive Species in Plant Physiology and Pathology

edited by

Bong-Gyu Mun

submission deadline 31 May 2026 | Viewed by 51 | Submission Open

Keywords: nitric oxide; reactive oxygen species; reactive sulfur species; redox signaling; S-nitrosylation; plant stress tolerance; antioxidant systems; phytohormones; metabolic regulation

(This special issue belongs to the Section Biological Factors)

Genetic Variations and Gene Expression in Diseases

edited by

Éva Kereszturi

submission deadline 31 May 2026 | Viewed by 50 | Submission Open

Keywords: omics; gene expression; genetic variation; SNPs; polymorphisms; complex traits; monogenic disorders; gene-environment interactions; transcriptomics; functional analysis

(This special issue belongs to the Section Molecular Biology)

Molecular Motors in Muscle: From Single Molecules to Tissue Function

edited by

Pasquale Bianco

submission deadline 31 May 2026 | Viewed by 45 | Submission Open

Keywords: molecular motors; muscle mechanics; motor protein energetics; cytoskeletal dynamics; single-molecule biophysics

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Bone Tissue Morphology: From Pathophysiological Mechanisms to Regenerative Strategies

edited by

Igor Erjavec

submission deadline 31 May 2026 | Viewed by 43 | Submission Open

Keywords: osteoporosis; bone cancer; fracture repair; regenerative biomaterials; bone remodeling; molecular mechanisms; biomechanical mechanisms; bone imaging techniques

(This special issue belongs to the Section Molecular Medicine)

Advances in Cardiometabolic Health, 2nd Edition

edited by Pamela Senesi and

Anna Ferrulli

submission deadline 31 May 2026 | Viewed by 40 | Submission Open

Keywords: obesity; cardiovascular diseases; biomarkers; lifestyle interventions; personalized medicine

(This special issue belongs to the Section Cellular Biochemistry)

Current and Future Molecular Insights into Hematological Diseases: From Diagnosis to Therapy

edited by Miguel Piris-Villaespesa,

Javier Leon

and

Fernando Martín-Moro

submission deadline 31 May 2026 | Viewed by 33 | Submission Open

Keywords: hematological diseases; diagnostic assessment; molecular biology; targeted therapies; lymphoid neoplasm; myeloid neoplasm

(This special issue belongs to the Section Molecular Medicine)

Molecular Pathogenesis and Emerging Therapeutic Targets and Strategies in Huntington’s Disease

edited by

Laszlo Bodai

and

Nora Zsindely

submission deadline 31 May 2026 | Viewed by 2 | Submission Open

Keywords: Huntington’ s disease; huntingtin; polyglutamine; neurodegeneration; pathogenesis; therapeutic targets; proteopathy; autophagy dysfunction; transcriptional dysregulation; mitochondrial dysfunction

(This special issue belongs to the Section Molecular Medicine)

Advances in Nano-Based Drug Delivery Systems

edited by

Amalendu P. Ranjan

Nirupama A. Sabnis

and

Zacharias Suntres

submission deadline 1 Jun 2026 | 2 articles | Viewed by 5141 | Submission Open

Keywords: drug delivery system; nanotechnology; nanomedicine; nanocarriers; nanoparticles; nanoformulation; biomolecules

(This special issue belongs to the Section Molecular Medicine)

Aldehyde Metabolism and Innate Immune Signaling in Cardiovascular Disease: From Pathogenesis to Regeneration

edited by Suresh S. Palaniyandi

submission deadline 1 Jun 2026 | Viewed by 70 | Submission Open

Keywords: reactive aldehydes (4-HNE; acrolein; and malondialdehyde); lipid peroxidation and oxidative stress; aldehyde detoxification enzymes (ALDH2; ALDHs; AKRs; and GSTs); glutathione and antioxidant defense systems; mitochondrial dysfunction and redox imbalance; protein adducts and cellular signaling; endothelial dysfunction and vascular injury; inflammation; innate immunity; and inflammasomes; cardiac remodeling; heart failure; and atherosclerosis; biomarkers and therapeutic strategies (enzyme activators; scavengers; and regeneration)

(This special issue belongs to the Section Molecular Medicine)

Emerging Bioactives from Underexplored Botanical Sources and By-Products for Food Applications

edited by Suelen Pereira Ruiz Herrig, Zilda Cristiani Gazim and Beatriz Cervejeira Bolanho Barros

submission deadline 1 Jun 2026 | Viewed by 49 | Submission Open

Keywords: botanical bioactives; by-products; natural food additives; green extraction

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Displaying special issue 351-400 on page 8 of 11.

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