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Biomolecules
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Transient Receptor Potential (TRP) Channels: More than Simple Biomarkers
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Transient Receptor Potential (TRP) Channels: More than Simple Biomarkers

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biomarkers".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 4704

Special Issue Editors

Dr. Maria Beatrice Morelli

E-Mail Website
Guest Editor
School of Pharmacy, University of Camerino, 62032 Camerino, Italy
Interests: glioblastoma; TRP channel; mucolipins; autophagy; overall survival; transient receptor potential channels; tumor progression; chemotherapy resistance;cancer biology; cancer stem cell; circulating tumor cell; liquid biopsy; biomarkers; ion channel; natural compound; cannabinoids
Special Issues, Collections and Topics in MDPI journals
Dr. Amantini Consuelo

E-Mail Website
Guest Editor
School of Bioscience and Biotechnology, University of Camerino, 62032 Camerino, Italy
Interests: TRP; cancer biology; apoptosis; autophagy; senescence; circulating stem cell; chemoresistance
Special Issues, Collections and Topics in MDPI journals
Dr. Federica Maggi

E-Mail Website
Guest Editor
School of Bioscience and Biotechnology, University of Camerino, 62032 Camerino, Italy
Interests: Transient Receptor Potential (TRP) Channels

Special Issue Information

Dear Colleagues,

Following a very successful first run, we are pleased to announce the launch of a second edition of the Transient Receptor Potential (TRP) Channels Special Issue.

It is now evident that ion channels such as TRPs play a crucial role in the development and progression of cancer. Although they are widespread in many tumors, TRP expression and activity within specific types of cancer can provide us with new clues regarding cancerous mechanisms. Moreover, identifying the specific TRP contributions in each phase of the cancerous process, from growth, invasion, angiogenesis, and drug resistance to metastasis formation, is essential to future research.

Therefore, this Special Issue of Biomolecules will explore the roles of TRPs in cancer. The main goal of the Special Issue is to collect articles that describe recent progress in elucidating the mechanisms by which these channels modulate tumor progression. The rapid evolution of tumor cell resistance to current therapeutic opportunities, despite extensive research efforts, means that neoplastic disease remains one of the leading causes of death and morbidity worldwide. In order to encourage innovation in clinical research, it is necessary to target previously unexplored cancer-relevant markers, such as TRP channels, which may reveal valuable information. Several natural products, such as capsaicinoids, cannabinoids and terpenes, have been demonstrated to function as TRP channel modulators, and have significantly contributed to our current knowledge on TRP biology. Therefore, we encourage scientists of diverse backgrounds to contribute original research or review articles covering studies on TRP characterization and translational approaches of clinical relevance.

Dr. Maria Beatrice Morelli
Dr. Amantini Consuelo
Dr. Federica Maggi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • TRP
  • cancer
  • ion channel
  • tumor progression
  • natural compound
  • calcium signaling
  • cell death
  • autophagy
  • senescence

Related Special Issue

Published Papers (2 papers)

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Research

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17 pages, 6645 KiB  
Article
Pan-Cancer Analysis of the TRP Family, Especially TRPV4 and TRPC4, and Its Expression Correlated with Prognosis, Tumor Microenvironment, and Treatment Sensitivity
by Zhenghao Chen, Youquan Zhao, Ye Tian, Rui Cao and Donghao Shang
Biomolecules 2023, 13(2), 282; https://doi.org/10.3390/biom13020282 - 02 Feb 2023
Cited by 3 | Viewed by 2168
Abstract
Background: Transient receptor potential (TRP) channels are involved in various physiological, pathological, and tumorigenesis-related processes. However, only a few studies have comprehensively analyzed TRP family members and their association with prognosis and tumor microenvironment (TME) in various cancers. Thus, in this study, we [...] Read more.
Background: Transient receptor potential (TRP) channels are involved in various physiological, pathological, and tumorigenesis-related processes. However, only a few studies have comprehensively analyzed TRP family members and their association with prognosis and tumor microenvironment (TME) in various cancers. Thus, in this study, we focused on TRP channels in pan-cancer and screened two typical TRP channels, TRPV4 and TRPC4, as examples. Methods: Based on the latest public databases, we evaluated the expression level and prognostic value of TRP family genes in pan-cancer tissues via various bioinformatic analytical methods, and investigated the relationship between the expression of TRP family genes with TME, stemness score, immune subtype, drug sensitivity, and immunotherapy outcome in pan-cancer tissues. Results: Pan-cancer analysis revealed that the TRP family genes were differentially expressed in tumor and para-carcinoma tissues. A significant correlation existed between the expression of TRP family genes and prognosis. The expression of TRP family genes was significantly correlated with stromal, immune, RNA stemness, and DNA stemness scores in pan-cancer tissues. Our results indicated that the expression of TRP family genes correlated with the sensitivity to various drugs including PLX-4720, SB-590885, and HYPOTHEMYCIN, immunotherapy outcome, and immune-activation-related genes. Immunohistochemical analysis revealed significant differential expression of TRPV4 in bladder and para-carcinoma tissues. Conclusions: Our study elucidated the possible role of TRP family genes in cancer progression and provided insights for further studies on TRP family genes as potential pan-cancer targets to develop diagnostic and therapeutic strategies. Full article
(This article belongs to the Special Issue Transient Receptor Potential (TRP) Channels: More than Simple Biomarkers)
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Review

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20 pages, 1100 KiB  
Review
Carcinogenesis and Metastasis: Focus on TRPV1-Positive Neurons and Immune Cells
by Nuray Erin and Arpad Szallasi
Biomolecules 2023, 13(6), 983; https://doi.org/10.3390/biom13060983 - 13 Jun 2023
Cited by 3 | Viewed by 2132
Abstract
Both sensory neurons and immune cells, albeit at markedly different levels, express the vanilloid (capsaicin) receptor, Transient Receptor Potential, Vanilloid-1 (TRPV1). Activation of TRPV1 channels in sensory afferent nerve fibers induces local effector functions by releasing neuropeptides (most notably, substance P) which, in [...] Read more.
Both sensory neurons and immune cells, albeit at markedly different levels, express the vanilloid (capsaicin) receptor, Transient Receptor Potential, Vanilloid-1 (TRPV1). Activation of TRPV1 channels in sensory afferent nerve fibers induces local effector functions by releasing neuropeptides (most notably, substance P) which, in turn, trigger neurogenic inflammation. There is good evidence that chronic activation or inactivation of this inflammatory pathway can modify tumor growth and metastasis. TRPV1 expression was also demonstrated in a variety of mammalian immune cells, including lymphocytes, dendritic cells, macrophages and neutrophils. Therefore, the effects of TRPV1 agonists and antagonists may vary depending on the prominent cell type(s) activated and/or inhibited. Therefore, a comprehensive understanding of TRPV1 activity on immune cells and nerve endings in distinct locations is necessary to predict the outcome of therapies targeting TRPV1 channels. Here, we review the neuro-immune modulation of cancer growth and metastasis, with focus on the consequences of TRPV1 activation in nerve fibers and immune cells. Lastly, the potential use of TRPV1 modulators in cancer therapy is discussed. Full article
(This article belongs to the Special Issue Transient Receptor Potential (TRP) Channels: More than Simple Biomarkers)
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