Transient Receptor Potential (TRP) Channels: More than Simple Biomarkers

Dear Colleagues,

Following a very successful first run, we are pleased to announce the launch of a second edition of the Transient Receptor Potential (TRP) Channels Special Issue.

It is now evident that ion channels such as TRPs play a crucial role in the development and progression of cancer. Although they are widespread in many tumors, TRP expression and activity within specific types of cancer can provide us with new clues regarding cancerous mechanisms. Moreover, identifying the specific TRP contributions in each phase of the cancerous process, from growth, invasion, angiogenesis, and drug resistance to metastasis formation, is essential to future research.

Therefore, this Special Issue of Biomolecules will explore the roles of TRPs in cancer. The main goal of the Special Issue is to collect articles that describe recent progress in elucidating the mechanisms by which these channels modulate tumor progression. The rapid evolution of tumor cell resistance to current therapeutic opportunities, despite extensive research efforts, means that neoplastic disease remains one of the leading causes of death and morbidity worldwide. In order to encourage innovation in clinical research, it is necessary to target previously unexplored cancer-relevant markers, such as TRP channels, which may reveal valuable information. Several natural products, such as capsaicinoids, cannabinoids and terpenes, have been demonstrated to function as TRP channel modulators, and have significantly contributed to our current knowledge on TRP biology. Therefore, we encourage scientists of diverse backgrounds to contribute original research or review articles covering studies on TRP characterization and translational approaches of clinical relevance.

Dr. Maria Beatrice Morelli
Dr. Amantini Consuelo
Dr. Federica Maggi
Guest Editors

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