Biomimetic Approach to Dental Implants: Third Edition

A special issue of Biomimetics (ISSN 2313-7673). This special issue belongs to the section "Biomimetics of Materials and Structures".

Deadline for manuscript submissions: 20 February 2026 | Viewed by 949

Special Issue Editors


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Guest Editor
Implant-Research Center, School of Dental Medicine, University of Belgrade, 11000 Belgrade, Serbia
Interests: bone regeneration; soft tissue integration; biocompatibility; bioactivity; Ti alloys; nHAP scaffolds
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Guest Editor
Implant-Research Center, School of Dental Medicine, University of Belgrade, 11000 Belgrade, Serbia
Interests: bone regeneration; periimplant deseases; bone inflamation; oral microbiome; bone scaffolds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue will focus on the integration of biomimetic approaches in the continuously evolving field of dental implantology. Different biomimetic materials and techniques, inspired by the intricate designs and mechanisms observed in nature, as well as their role in implant success enhancement, longevity, sustainability, and patient outcomes will be critically examined. Some of this Special Issue’s focal points will include, but are not limited to, the following:

  • Reviews examining biomimetic approaches in dental implants, focusing on how this paradigm aims to replicate the natural structure and function of lost tissues;
  • Studies on biomimetic materials in dental implantology, including scaffolds, bioactive coatings, surface modifications, and membranes designed for guided bone regeneration (GBR) and guided tissue regeneration (GTR), with the objective of closely replicating natural tissue regeneration processes;
  • Studies examining morphology and microarchitecture of natural bone, focusing on its role in implant design;
  • Studies on biomimetic approaches to soft tissue management around implants, such as gum healing, contouring, and aesthetics;
  • Studies dealing with biomimetic strategies for minimizing peri-implant diseases and implant failure;
  • In vitro and in vivo studies on the role of stem cells and tissue engineering in biomimetic implant development;
  • Studies assessing the use of 3D printing and nanotechnologies in dental implantology;
  • Studies investigating the biological basis of biomimetic implantology, focusing on cellular and molecular mechanisms;
  • Reviews addressing the long-term clinical outcomes associated with biomimetic implants;
  • Studies focusing on the sustainability of biomimetic implants and the implementation of various environmentally friendly approaches in their design, fabrication, and clinical application.

We look forward to receiving your contributions.

Dr. Dijana Mitic
Dr. Jelena Carkic
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dental implant
  • biological materials
  • periodontology
  • tissue engineering
  • biomimetic materials
  • osteointegration
  • periimplantitis

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Published Papers (1 paper)

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Research

12 pages, 2238 KB  
Article
An Evaluation of Osseointegration Outcomes Around Trabecular Metal Implants in Human Maxillaries Reconstructed with Allograft and Platelet-Rich Fibrin
by Sana Imani Oroumieh, Hana Shah, Andrew Nordlund, Luis Ignacio De Bellis Tulle, Bruno Martins de Souza, Anshumi Desai, Vasudev Vivekanand Nayak, Juan Carlos Carvajal Herrera, Lukasz Witek and Paulo G. Coelho
Biomimetics 2025, 10(11), 789; https://doi.org/10.3390/biomimetics10110789 - 20 Nov 2025
Viewed by 729
Abstract
Trabecular MetalTM (TM) dental implants comprise a tantalum (Ta)-based biomimetic open-cell structure designed to replicate the structural, functional, and physiological properties of cancellous bone. Yet, the current literature primarily focuses on the evaluation of osseointegration outcomes surrounding TM implants in uncompromised bone [...] Read more.
Trabecular MetalTM (TM) dental implants comprise a tantalum (Ta)-based biomimetic open-cell structure designed to replicate the structural, functional, and physiological properties of cancellous bone. Yet, the current literature primarily focuses on the evaluation of osseointegration outcomes surrounding TM implants in uncompromised bone environments and/or brief periods of observation in pre-clinical models. In addition, the performance of TM implants in bony defect environments reconstructed with allogenic grafts and bioactive molecules, such as platelet-rich fibrin (PRF), has not been thoroughly investigated. This longitudinal, randomized clinical trial comprised patients presenting with completely edentulous maxillaries. Guided Bone Regeneration (GBR) was performed using a cortico-cancellous allograft/PRF agglomerate. After 26 weeks, bone biopsies were obtained, followed by the insertion of a TM implant, after which patients were allowed to heal for 52 weeks for assessment of osseointegration. Qualitatively, histomicrographs at 26 weeks confirmed the presence of newly formed bone extending from the periphery of defects and along the direct surface of the allograft. TM implant biopsies at 52 weeks demonstrated osseointegration with bone ongrowth and ingrowth at the interconnected, porous trabecular region. These histological characteristics were consistent across all patients. No metal debris was detected, and the TM implants maintained their porous structure throughout the study period. TM implants placed in PRF-augmented allograft-reconstructed maxillae fostered a conducive environment for osseointegration. By leveraging the open-cell Ta structure, robust new bone formation was achieved without signs of adverse tissue reactions. Full article
(This article belongs to the Special Issue Biomimetic Approach to Dental Implants: Third Edition)
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