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Biomimetic Strategies to Enhance Bone Tissue Healing, Remodeling and Regeneration:...
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Biomimetic Strategies to Enhance Bone Tissue Healing, Remodeling and Regeneration: 2nd Edition

A special issue of Biomimetics (ISSN 2313-7673). This special issue belongs to the section "Biomimetics of Materials and Structures".

Deadline for manuscript submissions: 20 December 2025 | Viewed by 480

Special Issue Editor

Dr. Otto Carl Wilson, Jr.

E-Mail Website
Guest Editor
Department of Biomedical Engineering, Catholic University of America, Washington, DC, USA
Interests: biomineralization phenomena; nanomaterials chemistry; biological liquid crystals;healing and remodeling of hard tissue
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bone tissue displays several unique chemical, physical, and biological characteristics, making it one of the most fascinating tissues in the body. Bone tissue plays an important physical role in providing structural support for our bodies and the foundation for tendon and ligament attachment for movement. Bone tissue also provides a physical environment for protecting bone marrow tissue and internal organs. Bone tissue serves as a chemical storage depot for calcium and phosphate ions. These ions play a critically important role in a host of biological processes that are vital for life. These factors add to the importance of developing effective design strategies to maintain bone tissue health across the age spectrum from youth to old age. One of the most important considerations in designing materials to enhance bone healing involves ensuring that the intervention can accompany the orchestra that resonates during bone tissue healing and remodeling without eliciting unfavorable effects. 

Biomimetic design principles are based on learning from, modeling, and mimicking the processes that naturally occur during biological processes. Biomimetic design strategies and principles can be used to enhance the healing and remodeling of bone at the whole tissue, cellular, and subcellular levels and have shown much promise for future innovations in treatment. The focus of our Special Issue, entitled “Biomimetic Strategies to Enhance Bone Tissue Healing, Remodeling and Regeneration”, is to shine a spotlight on some of the key research studies that are being conducted in this field. These studies push the boundaries of our understanding of hard tissue healing phenomena and will pave the way for great advances in optimizing skeletal health for life on Earth and the challenges of space travel as we venture beyond the Earth. 

Dr. Otto Carl Wilson, Jr.
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomimetics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomimetic strategies
  • bone repair
  • 3D scaffolds
  • bioceramics
  • bone grafts
  • orthopedic implants
  • bionic prostheses
  • bioresorbable material
  • biomechanics

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Published Papers (1 paper)

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Research

12 pages, 2508 KB  
Article
Osseodensification Versus Subtractive Drilling in Cortical Bone: An Evaluation of Implant Surface Characteristics and Their Effects on Osseointegration
by Sara E. Munkwitz, Albert Ting, Hana Shah, Nicholas J. Iglesias, Vasudev Vivekanand Nayak, Arthur Castellano, Lukasz Witek and Paulo G. Coelho
Biomimetics 2025, 10(10), 662; https://doi.org/10.3390/biomimetics10100662 - 1 Oct 2025
Viewed by 341
Abstract
Osseodensification (OD) has emerged as a favorable osteotomy preparation technique that preserves and compacts autogenous bone along the osteotomy walls during site preparation, enhancing primary stability and implant osseointegration. While OD has demonstrated promising results in low-density trabecular bone, especially when used in [...] Read more.
Osseodensification (OD) has emerged as a favorable osteotomy preparation technique that preserves and compacts autogenous bone along the osteotomy walls during site preparation, enhancing primary stability and implant osseointegration. While OD has demonstrated promising results in low-density trabecular bone, especially when used in conjunction with acid-etched (AE) implant surfaces, its efficacy in high-density cortical bone remains unclear—particularly in the context of varying implant surface characteristics. In this study, Grade V titanium alloy implants (Ti-6Al-4V, 4 mm × 10 mm) with deep threads, designated bone chambers and either as-machined (Mach) or AE surfaces were placed in 3.8 mm diameter osteotomies in the submandibular region of 16 adult sheep using either OD or conventional (Reg) drilling protocols. Insertion torque values (N·cm) were measured at the time of implant placement to evaluate primary stability. Mandibles were harvested at 3-, 6-, 12-, or 24-weeks post-implantation (n = 4 sheep/time point), and histologic sections were analyzed to quantify bone-to-implant contact (BIC) and bone area fractional occupancy (BAFO). Qualitative histological analysis confirmed successful osseointegration among all groups at each of the healing time points. No statistically significant differences were observed between OD and conventional drilling techniques in insertion torque (p > 0.628), BIC (p > 0.135), or BAFO (p > 0.060) values, regardless of implant surface type or healing interval. The findings indicate that neither drilling technique nor implant surface treatment significantly influences osseointegration in high density cortical bone. Furthermore, as the osteotomy was not considerably undersized, the use of OD instrumentation showed no signs of necrosis, inflammation, microfractures, or impaired osseointegration in dense cortical bone. Both OD and Reg techniques appear to be suitable for implant placement in dense bone, allowing flexibility based on surgeon preference and clinical circumstances. Full article
(This article belongs to the Special Issue Biomimetic Strategies to Enhance Bone Tissue Healing, Remodeling and Regeneration: 2nd Edition)
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