Drug Development in Gastrointestinal Disorders
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Drug Discovery, Development and Delivery".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 33
Special Issue Editors
Interests: medicinal chemistry; organic synthesis; drug design and discovery; SAR; antispasmodics; gastrointestinal pharmacology; multitarget agents; hybrid molecules; memory modulation; neurogastroenterology
Interests: synthesis; drug discovery; medicinal chemistry; heterocyclic compounds; organic synthesis; hybrid molecules; nanoparticles; drug-delivery systems; drug-design
Special Issue Information
Dear Colleagues,
Gastrointestinal (GI) disorders encompass a broad spectrum of conditions affecting the digestive tract, liver, and pancreas, ranging from inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) to gastrointestinal cancers, functional dyspepsia, and non-alcoholic fatty liver disease (NAFLD). These disorders collectively represent a significant and growing global health burden, contributing to substantial morbidity, reduced quality of life, and escalating healthcare costs. Despite advances in understanding the pathophysiology of many GI diseases—including the roles of immune dysregulation, gut microbiome imbalance, epithelial barrier dysfunction, and neural-immune crosstalk—therapeutic development has faced persistent challenges.
This Special Issue aims to compile high-quality research and comprehensive reviews that address key challenges and opportunities in GI drug development. Focus areas include
- Mechanism-driven target discovery and validation in disease-relevant models;
- Innovative therapeutic modalities, including biologics, small molecules, cell-based therapies, and microbiome-targeted interventions;
- Advanced drug delivery systems designed for the GI tract;
- Biomarker development for therapeutic monitoring;
- Clinical trial strategies for complex GI disorders.
We look forward to receiving your contributions to this important collection.
Dr. Miglena Milusheva
Dr. Stoaynka Atanasova Nikolova
Guest Editors
Manuscript Submission Information
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Keywords
- inflammatory bowel disease (IBD)
- crohn's disease
- gastrointestinal disorders
- biologics
- small-molecule inhibitors
- drug delivery system
- therapeutic target
- drug resistance
- biomarker
- multitarget therapy
- nanoparticles
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