Integration of Multi-Omics Analysis and Biomaterial Innovation in Tissue Repair and Regeneration

Dear Colleagues,

Biomaterial-based strategies are at the forefront of tissue engineering and regenerative medicine, especially where intrinsic repair is limited, including severe burns, complex trauma, and musculoskeletal defects such as bone, cartilage, and tendon injuries—conditions that often result in long-term impairment. Recent advances in biomaterials, such as precise chemical control, innovative three-dimensional structural design, mechanical optimization, and programmable degradation or drug release, have opened new avenues for efficient and precise tissue repair and regeneration.

Concurrently, the deep integration of multi-omics technologies—encompassing transcriptomics, proteomics, metabolomics, epigenomics, as well as single-cell and spatial omics—with biomaterial engineering has significantly broadened our understanding of tissue repair and regeneration. High-resolution multi-omics data integration enables systematic dissection of cellular heterogeneity, immune microenvironment dynamics, and key regenerative signaling pathways, providing a solid basis for the rational design and functional optimization of biomaterials. This also supports improved therapeutic prediction, monitoring, and the advancement of personalized regenerative medicine.

This Special Issue highlights recent progress in experimental, computational, and translational research integrating multi-omics and biomaterial innovation for tissue repair and regeneration. We welcome original research and reviews on themes including multi-omics applications in tissue repair, novel or smart biomaterial development, mechanistic studies of omics-biomaterial synergy, multi-omics data integration and modeling, and translational or clinical advances in tissue repair and reconstruction. We look forward to receiving high-quality submissions to jointly advance the integration of fundamental multi-omics discoveries with advanced biomaterials engineering, thereby propelling further progress in tissue repair and regenerative medicine.

Dr. Zhiwen Luo
Guest Editor

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