Clinical Advances in Hepatocellular Carcinoma

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 202

Special Issue Editor


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Guest Editor
Deaconess Health System, Henderson, KY, USA
Interests: gastrointestinal malignancies; colorectal surgeries; inflammatory bowel diseases

Special Issue Information

Dear Colleagues,

Hepatocellular carcinoma (HCC) is the most common type of malignancy and the leading cause of death in patients with cirrhosis. Despite recent advances in the screening, diagnosis, and treatment options for patients with HCC, it remains one of the leading causes of cancer mortality in the USA and worldwide. While about 20% of patients with HCC present with stage IV disease, these patients have a five-year survival of about 3%. These estimates highlight the importance of the unmet need to improve screening programs, diagnostic methods, and treatment options for patients with HCC.

In this Special Issue, we aim to present a series of research articles that focus on screening, diagnosis and treatment options for patients with HCC. We welcome basic science, transitional, and clinical studies.

Dr. Mohamed A. Abd El Aziz
Guest Editor

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Keywords

  • hepatocellular cancer
  • liver cirrhosis
  • chemotherapy
  • immunotherapy
  • radiofrequency ablation
  • microwave ablation

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Published Papers (1 paper)

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Research

9 pages, 1421 KB  
Article
Utility of Dynamic 68Ga-DAZA-PET/CT for Bile Leak Localization After Liver Transplantation: First Clinical Experiences
by Anke Werner, Oliver Rohland, Julia Greiser, Martin Freesmeyer, Utz Settmacher, Robert Drescher and Felix Dondorf
Biomedicines 2026, 14(1), 22; https://doi.org/10.3390/biomedicines14010022 - 22 Dec 2025
Abstract
Background/Objectives: Biliary complications are common after liver transplantation (LT), with bile leaks representing a major cause of morbidity. Conventional imaging modalities such as ultrasound, CT, MRCP, and endoscopic techniques may fail to localize peripheral or complex leaks. This study aimed to evaluate [...] Read more.
Background/Objectives: Biliary complications are common after liver transplantation (LT), with bile leaks representing a major cause of morbidity. Conventional imaging modalities such as ultrasound, CT, MRCP, and endoscopic techniques may fail to localize peripheral or complex leaks. This study aimed to evaluate the feasibility of [68Ga]Ga-TEoS-DAZA-PET/CT for non-invasive localization of bile leaks after LT. Methods: Five male patients (mean age 53.2 years) with suspected bile leakage and inconclusive prior imaging underwent [68Ga]Ga-TEoS-DAZA-PET/CT. The tracer was synthesized under GMP conditions and administered at a mean activity of 204 ± 42 MBq. Dynamic PET/CT imaging was performed for 60 min, and findings were classified according to the Nagano classification. Results: Bile leaks were detected and anatomically localized in all five patients. Sites included the liver resection surface, central bile ducts, bilioenteric anastomosis, and biliary drainage exit. PET/CT findings guided revision surgery in one case and endoscopic treatment in three, while one patient improved without intervention. No adverse effects occurred. Conclusions: [68Ga]Ga-TEoS-DAZA-PET/CT is a feasible and safe imaging technique for the anatomical localization of bile leaks following LT. Its antegrade visualization of biliary flow, high spatial and temporal resolution, and lack of contraindications make it a promising complementary modality when conventional imaging is inconclusive or not feasible. Larger studies are warranted to validate its diagnostic value and clinical utility in postoperative and post-traumatic biliary injuries. Full article
(This article belongs to the Special Issue Clinical Advances in Hepatocellular Carcinoma)
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