Mechanisms and Management of Chronic Pain: Nociceptive, Neuropathic, and Nociplastic Perspectives
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: closed (1 July 2026) | Viewed by 898
Editor
Interests: headache; chronic pain; physical therapy; rehabilitation; sensitization; mechanisms
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic pain represents a continuous challenge for clinicians and researchers. In recent decades, there have been increasing advances in the mechanisms and management of chronic pain since a better understanding of its mechanisms can lead to personalized-tailored treatments. Due to the heterogeneity clinical presentation of chronic pain conditions, three pain phenotypes, i.e., nociceptive, neuropathic and nociplastic pain, as well as a mixed-type phenotype, were proposed for classification of chronic pain. This classification was originally described for research purposes and has been slightly criticized for its clinical application because of discrimination between these pain phenotypes in clinical practice can be difficult since a patient can fit into more than one pain phenotype, where one type (i.e., neuropathic) does not exclude another phenotype (i.e., nociplastic), or can evolve from one to another phenotype with time. We are pleased to invite you to submit manuscripts to this Special Issue “Mechanisms and Management of Chronic Pain: Nociceptive, Neuropathic, and Nociplastic Perspectives”.
This Special Issue aims to better understand those mechanisms of chronic pain by applying this classification of nociceptive, neuropathic and nociplastic pain phenotypes into specific pain conditions. This Special Issue will focus on mechanisms and treatment aspects of chronic pain and its classification into nociceptive, neuropathic and nociplastic pain phenotypes and the identification of this classification to serve as a potential predictor of personalized-tailored treatment approaches.
We invite researchers/clinicians to submit original articles, systematic reviews, narrative reviews, meta-analysis, cohort and case–control studies related to mechanisms and management of chronic pain.
Prof. Dr. César Fernández-de-las-Peñas
Guest Editor
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Keywords
- pain
- nociplastic
- sensitization
- neuropathic
- mechanisms
- treatment
- classification
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