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Biomedicines
Special Issues
Advances in Extracellular Vesicles in Therapeutics
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Advances in Extracellular Vesicles in Therapeutics

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".

Deadline for manuscript submissions: closed (30 September 2025) | Viewed by 201

Special Issue Editors

Dr. Mangesh D. Hade

E-Mail Website
Guest Editor
Center for Clinical and Translational Research, Nationwide Children's Hospital, 700 Children's Dr, Columbus, OH 43205, USA
Interests: extracellular vesicles; exosomes; mesenchymal stem cells; drug delivery; miRNA; cell-based therapies; wound healing; neurodegenerative diseases; cardiovascular diseases; growth factors; regenerative medicine
Special Issues, Collections and Topics in MDPI journals
Dr. Akil Akhtar

E-Mail Website
Guest Editor
Emory Vaccine Center, Division of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
Interests: immunology; microbiology; host immune mechanisms
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Extracellular vesicles (EVs) have emerged as promising therapeutic agents in a variety of medical applications. These nanoscale vesicles, including exosomes, microvesicles, and apoptotic bodies, are secreted by most cell types. They have been shown to play critical roles in cell-to-cell communication, signal transduction, and a variety of physiological and pathological processes. Due to their inherent ability to transport nucleic acids, proteins, lipids, and other bioactive molecules, EVs are being investigated as potential carriers for drug delivery and as biomarkers for disease diagnosis.

This Special Issue aims to explore the latest advancements in the field of EVs. The focus is on their therapeutic applications, mechanisms of action, and innovative strategies for harnessing their potential in clinical settings. Topics include, but are not limited to, the following:

  • The molecular mechanisms governing the formation, release, and uptake of EVs.
  • The involvement of EVs in various diseases, including cancer, neurodegenerative disorders, cardiovascular diseases, and autoimmune conditions.
  • Mechanistic studies elucidating how EVs contribute to disease progression, immune modulation, and tissue repair.
  • EVs as drug delivery systems.
  • The role of EVs in personalized medicine.

We invite submissions of original research articles and review papers that address these significant themes.

We look forward to receiving your contributions.

Dr. Mangesh D. Hade
Dr. Akil Akhtar
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • extracellular vesicles (EVs)
  • exosomes
  • regenerative medicine
  • immunotherapy
  • nanocarriers
  • biomarkers

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Published Papers (1 paper)

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28 pages, 1878 KB  
Review
Exosomes in Osteoarthritis: Breakthrough Innovations and Advanced Tissue Engineering for Cartilage Regeneration Since 2020
by Xiao-He Yang, Shu-Yin Chen, Quan-Fa Zhou and You-Zhi Cai
Biomedicines 2025, 13(10), 2486; https://doi.org/10.3390/biomedicines13102486 (registering DOI) - 13 Oct 2025
Abstract
Background/Objectives: Osteoarthritis (OA) is a prevalent age-related degenerative joint disease causing cartilage damage, leading to a debilitating lifestyle. However, there are currently no drugs on the market that promote cartilage repair, and advanced cases often require arthroplasty. Increasing evidence suggests that exosomes, the [...] Read more.
Background/Objectives: Osteoarthritis (OA) is a prevalent age-related degenerative joint disease causing cartilage damage, leading to a debilitating lifestyle. However, there are currently no drugs on the market that promote cartilage repair, and advanced cases often require arthroplasty. Increasing evidence suggests that exosomes, the smallest extracellular vesicles (30–150 nm) secreted by all cell types, are involved in the pathological process of OA and play a crucial and complex role in its progression. This review aims to provide in-depth insights into exosome biology, isolation techniques, their role in OA pathophysiology, and their clinical therapeutic potential. Methods: We systematically reviewed studies published since 2020 on exosomes in OA, focusing on their biological properties, isolation techniques, pathological roles, and therapeutic applications. Results: Exosomes derived from synovial fluid, chondrocytes, synoviocytes, and mesenchymal stem cells regulate key processes in OA progression, including inflammation, apoptosis, extracellular matrix degradation, and regeneration. Various cell-derived exosomes show therapeutic potential for cartilage damage/OA. However, their mechanisms of action have not been fully investigated. Moreover, emerging methodologies, such as utilizing novel materials for exosome delivery, potentially facilitate the development of more effective and personalized therapeutic interventions. Conclusions: Exosomes exert dual roles in OA pathogenesis and therapy. Although challenges remain regarding their sources, dosage, delivery, and standardization, exosome-based strategies represent a promising cell-free therapeutic approach with potential applications in personalized and precision medicine. Full article
(This article belongs to the Special Issue Advances in Extracellular Vesicles in Therapeutics)
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