Biological Therapies for Asthma: Targeting Type 1 and Type 2 Inflammation
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 1806
Special Issue Editors
Interests: asthma; airway inflammation; physiology; cardiometabolic disease; molecular biology
Special Issue Information
Dear Colleagues,
Asthma is a complex and varied disease driven by different types of inflammation, mainly type 1 and type 2. While type 1 inflammation, often associated with non-allergic asthma, remains less understood and harder to treat, recent advances are starting to shed light on its mechanisms and potential treatment targets. On the other hand, type 2 inflammation is linked to allergic asthma and driven by cytokines like IL-4, IL-5, and IL-13. Type 2 inflammation has been the focus of many effective biological therapies now available in clinical practice.
This Special Issue invites contributions that explore the role of biological therapies in targeting both the type 1 and type 2 inflammation in asthma. We aim to cover the following topics:
- The biological mechanisms driving type 1 and type 2 inflammation and how they shape asthma subtypes.
- New and existing biological treatments for both types of inflammation, including their clinical benefits and limitations.
- Biomarkers that help identify type 1 and type 2 inflammation and predict responses to treatment.
- Comparative studies on outcomes, effectiveness, and challenges in treating these two types of inflammation.
- Personalized treatment approaches based on inflammatory patterns of asthma.
By bringing together insights from researchers and clinicians, this Special Issue aims to advance our understanding of how biologicals can be used to address the different inflammatory processes in asthma, paving the way for more personalized and effective treatments.
Dr. Mohammad Irshad Reza
Dr. Nilesh Sudhakar Ambhore
Guest Editors
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Keywords
- asthma endotypes
- type 1 inflammation
- type 2 inflammation
- biological therapies for asthma
- non-type 2 asthma
- cytokine pathways in asthma
- precision medicine in asthma
- inflammatory biomarkers in asthma
- Th1/Th2 immune responses
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