Strategies for Anticancer in p53 Mutated Cancers
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 46
Special Issue Editors
Interests: p53 family; tumor suppressor gene; stem cell and cancer stem cell; missense mutation and nonsense mutation; drug resistance in cancer; immunotherapy; dermatology; head and neck cancer
Special Issues, Collections and Topics in MDPI journals
Interests: treatment of hypopharyngeal cancer, nasopharyngeal cancer, sinonasal cancer, and other head and neck cancer; p53 family and CTTN/EMS1 gene and their relation to head and neck cancer; impact of internal carotid artery invasion by head and neck cancer; internal carotid artery aberrancy; biomedical engineering
Special Issue Information
Dear Colleagues,
The p53 gene is a key tumor suppressor but is frequently mutated in nearly all types of cancers, with an average mutation rate of ~50%. Most mutated p53 proteins are highly expressed and acquire oncogenic functions that promote cancer progression and confer high resistance to anticancer drugs. Various approaches have been explored to develop strategies against cancers with highly expressed mutant p53 genes. These strategies include the following: 1. The direct reactivation of mutated p53. 2. The activation of other p53 family members, such as p63 or p73. 3. The degradation of mutated p53. 4. Blocking oncogenic microRNAs or long non-coding RNAs downstream of mutated p53.
New ideas, methods, and reviews regarding targeting mutant p53 genes in different cancer types are invited for inclusion in this special issue.
Dr. Bi-He Cai
Dr. Ching-Feng Lien
Guest Editors
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Keywords
- p53
- p63
- p73
- tumor suppressor gene
- microRNA
- long non-coding RNA
- protein degradation
- heat shock proteins
- mutation
- oncology
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