Special Issue "Phytochemical Antioxidants and Health"

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: 31 March 2019

Special Issue Editor

Guest Editor
Prof. Baojun Xu

Food Science and Technology Program, Beijing Normal University-Hong Kong Baptist University United International College, China
Website | E-Mail
Interests: antioxidants; phytochemicals; natural products; polyphenols; oxidative stress

Special Issue Information

Dear Colleagues,

It is widely accepted that free-radical-induced oxidative damage is involved with various human diseases, such as cardiovascular diseases, neural disorders, such as Alzheimer’s and Parkinson’s disease, diabetes, obesity, and various cancers. Antioxidants are substances that delay or inhibit oxidative damage when present in small quantities compared to an oxidizable substrate. Therefore, antioxidants can help in disease prevention by effectively quenching free radicals or inhibiting damage caused by them. It is recognized that the health effects of natural products including food and herbal medicines are generally associated with antioxidative activities or free radical scavenging properties of phytochemicals.

We invite you to contribute your latest research findings or a review article to this Special Issue, which will bring together current research concerning and critical thinking on phytochemical antioxidants, and the role that antioxidants can play in reducing oxidative stress in various disease statuses. Your contribution can include either in vitro or in vivo studies relating to any of the following topics: Antioxidative activities of phytochemicals; molecular mechanisms of phytochemical antioxidants in disease prevention; and the role of phytochemicals or antioxidants in signaling, cell metabolism, cell cycle, cellular stress, and chronic diseases.

We look forward to your contribution.

Prof. Baojun Xu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 550 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Antioxidants
  • Oxidative stress
  • Free radical scavenging
  • Phytochemicals
  • Molecular mechanisms
  • Health promotion
  • Disease prevention

Published Papers (2 papers)

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Research

Open AccessArticle Inhibitory Effects of Auraptene and Naringin on Astroglial Activation, Tau Hyperphosphorylation, and Suppression of Neurogenesis in the Hippocampus of Streptozotocin-Induced Hyperglycemic Mice
Antioxidants 2018, 7(8), 109; https://doi.org/10.3390/antiox7080109
Received: 24 July 2018 / Revised: 10 August 2018 / Accepted: 17 August 2018 / Published: 19 August 2018
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Abstract
Auraptene, a citrus-related compound, exerts anti-inflammatory effects in peripheral tissues, and we demonstrated these effects in the brains of a lipopolysaccharide-injected systemic inflammation animal model and a brain ischemic mouse model. Naringin, another citrus-related compound, has been shown to exert antioxidant effects in
[...] Read more.
Auraptene, a citrus-related compound, exerts anti-inflammatory effects in peripheral tissues, and we demonstrated these effects in the brains of a lipopolysaccharide-injected systemic inflammation animal model and a brain ischemic mouse model. Naringin, another citrus-related compound, has been shown to exert antioxidant effects in several animal models. Hyperglycemia induces oxidative stress and inflammation and causes extensive damage in the brain; therefore, we herein evaluated the anti-inflammatory and other effects of auraptene and naringin in streptozotocin-induced hyperglycemic mice. Both compounds inhibited astroglial activation and the hyperphosphorylation of tau at 231 of threonine in neurons, and also recovered the suppression of neurogenesis in the dentate gyrus of the hippocampus in hyperglycemic mice. These results suggested that auraptene and naringin have potential effects as neuroprotective agents in the brain. Full article
(This article belongs to the Special Issue Phytochemical Antioxidants and Health)
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Open AccessArticle Protective Effect of Aqueous Extract from the Leaves of Justicia tranquebariesis against Thioacetamide-Induced Oxidative Stress and Hepatic Fibrosis in Rats
Antioxidants 2018, 7(7), 78; https://doi.org/10.3390/antiox7070078
Received: 6 May 2018 / Revised: 9 June 2018 / Accepted: 17 June 2018 / Published: 22 June 2018
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Abstract
The present study aims to examine the protective effect of Justicia tranquebariesis on thioacetamide (TAA)-induced oxidative stress and hepatic fibrosis. Male Wister albino rats (150–200 g) were divided into five groups. Group 1 was normal control. Group 2 was J. tranquebariensis (400 mg/kg
[...] Read more.
The present study aims to examine the protective effect of Justicia tranquebariesis on thioacetamide (TAA)-induced oxidative stress and hepatic fibrosis. Male Wister albino rats (150–200 g) were divided into five groups. Group 1 was normal control. Group 2 was J. tranquebariensis (400 mg/kg bw/p.o.)-treated control. Group 3 was TAA (100 mg/kg bw/s.c.)-treated control. Groups 4 and 5 were orally administered with the leaf extract of J. tranquebariensis (400 mg/kg bw) and silymarin (50 mg/kg bw) daily for 10 days with a subsequent administration of a single dose of TAA (100 mg/kg/s.c.). Blood and livers were collected and assayed for various antioxidant enzymes (SOD, CAT, GPx, GST, GSH, and GR). Treatment with J. tranquebariensis significantly reduced liver TBARS and enhanced the activities of antioxidant enzymes in TAA-induced fibrosis rats. Concurrently, pretreatment with J. tranquebariensis significantly reduced the elevated liver markers (AST, ALT, ALP, GGT, and TB) in the blood. In addition, J. tranquebariensis- and silymarin- administered rats demonstrated the restoration of normal liver histology and reduction in fibronectin and collagen deposition. Based on these findings, J. tranquebariensis has potent liver protective functions and can alleviate thioacetamide-induced oxidative stress, hepatic fibrosis and possible engross mechanisms connected to antioxidant potential. Full article
(This article belongs to the Special Issue Phytochemical Antioxidants and Health)
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