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Open AccessArticle

Functional Analysis of Macromolecular Polysaccharides: Whitening, Moisturizing, Anti-Oxidant, and Cell Proliferation

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Department of Internal medicine of Gangshan Branch of Kaohsiung Armed Forces General Hospital, National Defense Medical Center, Kaohsiung 82049, Taiwan
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Program in Tissue Engineering and Regenerative Medicine, National Chung Hsing University, Taichung 402, Taiwan
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Graduate institute of biomedical engineering, Chung Hsing University, Taichung 402, Taiwan
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Department of Chemical Engineering, National Chung Hsing University, Taichung 402, Taiwan
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Department of Vegetable, College of Horticulture, China Agricultural University, Beijing 100193, China
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Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
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Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404, Taiwan
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Authors to whom correspondence should be addressed.
Antioxidants 2019, 8(11), 533; https://doi.org/10.3390/antiox8110533
Received: 1 October 2019 / Revised: 2 November 2019 / Accepted: 4 November 2019 / Published: 7 November 2019
(This article belongs to the Special Issue Phytochemical Antioxidants and Health)
In this research we utilized extracts from two different nature products, Achatina fulica and Heimiella retispora, to enhance skin moisturizing abilities, anti-oxidative properties, and cell proliferations. It was observed that two polysaccharides with anti-oxidative effects by chelating metal ions reduced oxidative stress and further blocked the formation of reactive oxygen species syntheses. To detect whether there was a similar effect within the cellular mechanism, a flow cytometry was applied for sensing the oxidative level and it was found that both materials inhibited the endogenous oxidative stress, which was induced by phorbol-12-myristate-13-acetate (PMA). Both polysaccharides also stimulated the production of collagen to maintain skin tightness and a moisturizing effect. In summary, we developed two macromolecular polysaccharides with potential applications in dermal care. View Full-Text
Keywords: Achatina fulica; Heimiella retispora; reactive oxygen species (ROS), collagen; moisturizing Achatina fulica; Heimiella retispora; reactive oxygen species (ROS), collagen; moisturizing
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Kao, C.-J.; Chou, H.-Y.; Lin, Y.-C.; Liu, Q.; David Wang, H.-M. Functional Analysis of Macromolecular Polysaccharides: Whitening, Moisturizing, Anti-Oxidant, and Cell Proliferation. Antioxidants 2019, 8, 533.

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