Fungal Biotechnology and Application 3.0

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungi in Agriculture and Biotechnology".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 768

Special Issue Editor

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Guest Editor
Food Science and Technology Program, Department of Life Sciences, Beijing Normal University-Hong Kong Baptist University United International College, Zhuhai 519087, China
Interests: food science; phytochemicals; nutraceuticals; pharmaceuticals; functional foods; molecular nutrition; cell biology
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Special Issue Information

Dear Colleagues,

This Special Issue (SI) calls for submissions of either original studies or literature reviews that describe the biotechnology and advanced applications of fungi which are beneficial or harmful to human beings. This SI will collect recent original research findings and critical reviews on current fungal biotechnology and the industrial application of fungi in the fields of cosmetics, food and pharmaceuticals. The topics of interest include but are not limited to:

  • The application of fungi in all kinds of industries (e.g., scientific research, fermentation for cosmetic ingredients and pharmaceuticals, and food);
  • Fungal secondary metabolites and metabolic flow analysis;
  • Bioprospecting of novel fungi from specific environments;
  • Mechanisms of pathogenic fungal infection and its prevention and treatment;
  • Ecology, morphological and ultrastructural diversity of fungi;
  • Cultivation and utilization of medicinal or edible mushrooms.

Prof. Dr. Baojun Xu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • biotechnology
  • utilization
  • health benefits
  • secondary metabolites
  • fermentation
  • mushroom
  • practical applications

Published Papers (1 paper)

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14 pages, 4996 KiB  
Effects of Light on the Fruiting Body Color and Differentially Expressed Genes in Flammulina velutipes
by Ji-Hoon Im, Che-Hwon Park, Ju-Hyeon Shin, Youn-Lee Oh, Minji Oh, Nam-Chon Paek and Young-Jin Park
J. Fungi 2024, 10(6), 372; - 22 May 2024
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Light plays vital roles in fungal growth, development, reproduction, and pigmentation. In Flammulina velutipes, the color of the fruiting body exhibits distinct changes in response to light; however, the underlying molecular mechanisms remain unknown. Therefore, in this study, we aimed to analyze [...] Read more.
Light plays vital roles in fungal growth, development, reproduction, and pigmentation. In Flammulina velutipes, the color of the fruiting body exhibits distinct changes in response to light; however, the underlying molecular mechanisms remain unknown. Therefore, in this study, we aimed to analyze the F. velutipes transcriptome under red, green, and blue light-emitting diode (LED) lights to identify the key genes affecting the light response and fruiting body color in this fungus. Additionally, we conducted protein–protein interaction (PPI) network analysis of the previously reported fruiting body color-related gene, Fvpal1, to identify the hub genes. Phenotypic analysis revealed that fruiting bodies exposed to green and blue lights were darker than those untreated or exposed to red light, with the color intensifying more after 48 h of exposure to blue light compared to that after 24 h of exposure. Differentially expressed gene (DEG) analyses of all light treatments for 24 h revealed that the numbers of DEGs were 17, 74, and 257 under red, green, and blue lights, respectively. Subsequently, functional enrichment analysis was conducted of the DEGs identified under green and blue lights, which influenced the color of F. velutipes. In total, 103 of 168 downregulated DEGs under blue and green lights were included in the enrichment analysis. Among the DEGs enriched under both green and blue light treatments, four genes were related to monooxygenases, with three genes annotated as cytochrome P450s that are crucial for various metabolic processes in fungi. PPI network analysis of Fvpal1 revealed associations with 11 genes, among which the expression of one gene, pyridoxal-dependent decarboxylase, was upregulated in F. velutipes exposed to blue light. These findings contribute to our understanding of the molecular mechanisms involved in the fruiting body color changes in response to light and offer potential molecular markers for further exploration of light-mediated regulatory pathways. Full article
(This article belongs to the Special Issue Fungal Biotechnology and Application 3.0)
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