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Antibiotics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Antimicrobial Stewardship in Neonatal Intensive Care

edited by Chiara Poggi

submission deadline 30 May 2026 | 2 articles | Viewed by 2420 | Submission Open

Keywords: neonatal sepsis; early onset sepsis; late onset sepsis; preterm; antimicrobial stewardship; neonatal intensive care; molecular diagnosis; stopping rule; therapeutic drug monitoring; extended antimicrobial infusion; continuous antimicrobial infusion; microbiological surveillance

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Innovative and Translational Antibiosis Approaches to Tackling Protozoan Parasites: Synergy, Drug Repurposing, Natural Products, Molecular Targets, and Therapeutic Design

edited by

Leonardo Acuña

submission deadline 30 May 2026 | 1 articles | Viewed by 1619 | Submission Open

Keywords: drug repurposing for neglected tropical diseases; natural products with antiparasitic activity; synergistic drug combinations; molecular targets and mechanisms of action

Antibiofilm Activity against Multidrug-Resistant Pathogens

edited by

Verica Aleksic Sabo

and Petar Knezevic

submission deadline 31 May 2026 | 9 articles | Viewed by 34115 | Submission Open

Keywords: biofilm; microbial drug resistance; antibiofilm agents; antibiofilm strategies; synergistic interactions

(This special issue belongs to the Section Antibiofilm Strategies)

Mechanism of Carbapenem Resistance in Enterobacteriaceae, Acinetobacter and Pseudomonas aeruginosa

edited by

Ágnes Pál-Sonnevend

submission deadline 31 May 2026 | 6 articles | Viewed by 25986 | Submission Open

Keywords: gram-negative infections; mechanism of carbapenem resistance; molecular epidemiology; in vitro diagnostic tools; antimicrobial treatment; beta-lactam/beta lactamase inhibitors; cefiderocol

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Therapy of Infectious Diseases Among Children and Adults: The Role of Antibiotics in Daily Practice

edited by

Magdalena Baymakova

and

Valeri R. Velev

submission deadline 31 May 2026 | 15 articles | Viewed by 23532 | Submission Open

Keywords: аntibiotic use among children; аntibiotic use among adults; аntibiotic use among outpatients; аntibiotic use among inpatients; antibiotic resistance; improper antibiotic use; antibiotic quality control

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Environmental Fate of Antibiotics: Monitoring, Toxicity, Resistance, and Removal Methods

edited by

Takashi Azuma

submission deadline 31 May 2026 | 8 articles | Viewed by 23152 | Submission Open

Keywords: antimicrobials; high-throughput analysis; wastewater treatment plant (WWTP); hospital wastewater; livestock environment; water purification plant (WTP); aquatic environment; environmental health risk assessment; antimicrobial resistance (AMR); advanced water treatment

Insights into Natural Antimicrobial Peptides

edited by

András Fodor

Eustachio Tarasco

and

Maurizio Francesco Brivio

submission deadline 31 May 2026 | 4 articles | Viewed by 18936 | Submission Open

Keywords: antibacterial host defense peptides; antibacterial mode of action; defensins; cathelicidins; insect antimicrobial peptides; plant antimicrobial peptides

(This special issue belongs to the Section Antimicrobial Peptides)

A One Health Approach to Antimicrobial Resistance, 2nd Edition

edited by

Beatriz Robredo

submission deadline 31 May 2026 | 8 articles | Viewed by 16870 | Submission Open

Keywords: One Health; antibiotic; antimicrobial resistance; animal; food; environment

Antibiotic Residues, Antimicrobial Resistance and Intervention Strategies of Foodborne Pathogens, 2nd Edition

edited by

Yongning Wu

and

Zhenling Zeng

submission deadline 31 May 2026 | 6 articles | Viewed by 16611 | Submission Open

Keywords: antibiotic residues; antibiotic resistance genes; antimicrobial resistance; food safety; foodborne pathogen; intervention strategies; one health

Revolutionizing Infection Treatment: Cutting-Edge Approaches in Antimicrobial Stewardship

edited by Jacob Myles Keck and

Aleksandra Barac

submission deadline 31 May 2026 | 5 articles | Viewed by 13563 | Submission Open

Keywords: antimicrobial stewardship; antimicrobial resistance; infection treatment optimization; rapid diagnostics; technology in healthcare

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Emerging Topics in Clostridioides difficile Infection: A One Health Problem

edited by

Simon D. Baines

submission deadline 31 May 2026 | 4 articles | Viewed by 12002 | Submission Open

Keywords: clostridium difficile infection (CDI); antimicrobial resistance (AMR); antimicrobial prescribing; one health; laboratory studies

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Molecular Epidemiology and Mechanisms of Carbapenem Resistance in Clinical Gram-Negative Bacteria

edited by

Ángel Rodríguez-Villodres

and José Manuel Ortiz De La Rosa

submission deadline 31 May 2026 | 5 articles | Viewed by 11729 | Submission Open

Keywords: carbapenem resistance; Enterobacterales; Pseudomonas aeruginosa; Acinetobacter baumannii; molecular epidemiology

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Antimicrobial Prescribing, Population Use and Resistance, Impact in Global Health, 3rd Edition

edited by

Juan Manuel Vázquez-Lago

Ana Estany-Gestal

and

Angel Salgado-Barreira

submission deadline 31 May 2026 | 2 articles | Viewed by 8257 | Submission Open

Keywords: epidemiology; social behavior; antibiotic resistance; social factors; attitudes; knowledge; practice; qualitative research; public health interventions; antibiotic prescription; community care

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Optimizing Antimicrobial Therapy in NICU Settings: Strategies and Implications

edited by

Elias Iosifidis

and

Angeliki Kontou

submission deadline 31 May 2026 | 2 articles | Viewed by 7823 | Submission Open

Keywords: neonatal ICU; antimicrobial stewardship; antimicrobial resistance; neonatal sepsis; biomarkers

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Periprosthetic Joint Infection: Understanding the Epidemiology, Pathogenesis, Diagnosis and Treatment Options

edited by Saad Tarabichi, Mark J. Spangehl and Joshua S. Bingham

submission deadline 31 May 2026 | 4 articles | Viewed by 5792 | Submission Open

Keywords: periprosthetic joint infection; diagnosis; epidemiology; pathogenesis; treatment

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Antibiotic Resistance in Bacterial Isolates of Animal Origin

edited by

Tomasz Jarzembowski

and

Lidia Piechowicz

submission deadline 31 May 2026 | 6 articles | Viewed by 5646 | Submission Open

Keywords: zoonotic infection; resistance genes; “ one health concept” ; Salmonella enterica; Campylobacter jejuni; enterohemorrhagic Escherichia coli; Enterococcus faecalis

(This special issue belongs to the Section Antibiotics in Animal Health)

Genomic Surveillance of Antimicrobial Resistance (AMR)

edited by Linzy Elton

submission deadline 31 May 2026 | 5 articles | Viewed by 5401 | Submission Open

Keywords: antimicrobial resistance; sequencing; genomics; surveillance; mobile genetic elements; multi-drug-resistant organisms; One Health; metagenomics; whole-genome sequencing

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Fungal Metabolites and Synthetic Derivatives as Sources of Antimicrobial Agents: From Discovery to Therapeutic Potential

edited by

João Vicente Braga De Souza

submission deadline 31 May 2026 | 2 articles | Viewed by 5064 | Submission Open

Keywords: antimicrobial resistance; fungal metabolites; synthetic derivatives; antifungal agents; bioactive compounds

(This special issue belongs to the Section Fungi and Their Metabolites)

Antibiotic Resistance and Antimicrobial Stewardship in Veterinary Medicine

edited by Tiana Florea,

Ilie Stelian

and

Degi Janos

submission deadline 31 May 2026 | 4 articles | Viewed by 4736 | Submission Open

Keywords: antimicrobial stewardship; antibiotics; animals; sustainability; drugs; antimicrobial resistance

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Animal-Origin Bacteria: Diversity, Pathogenicity and Antimicrobial Resistance

edited by

Juliana Menezes

Joana Moreira da Silva

and

Adriana Belas

submission deadline 31 May 2026 | 3 articles | Viewed by 3893 | Submission Open

Keywords: AMR; virulence; bacteria; zoonosis; companion animals; alternative therapy; food-producing animals; exotic animals; wildlife; One Health

Challenges of Antibiotic Resistance: Biofilms and Anti-Biofilm Agents

edited by

María Melissa Gutiérrez-Pacheco

and

Luis Alberto Ortega-Ramirez

submission deadline 31 May 2026 | 3 articles | Viewed by 3571 | Submission Open

Keywords: antibiotic resistance; biofilms; quorum sensing; virulence factors; resistance mechanisms; antibiofilm agents; natural compounds; synthetic drugs

(This special issue belongs to the Section Antibiofilm Strategies)

The Discovery of Novel Antimicrobial Agents to Combat Infections

edited by

Yuanpu Peter Di

submission deadline 31 May 2026 | 1 articles | Viewed by 3435 | Submission Open

Keywords: antimicrobials; resistance; bacteriophage; virulence; structure; PD/PK; bacteria; virus; fungus

(This special issue belongs to the Section Novel Antimicrobial Agents)

Antibiotic Resistance Genes: Mechanisms, Evolution and Dissemination

edited by

Ivo Nikolaev Sirakov

and

Slawomir Ciesielski

submission deadline 31 May 2026 | 3 articles | Viewed by 2276 | Submission Open

Keywords: antibiotic resistance genes; transposons; integrons; gene transfer; therapy

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

ESKAPEE: Mechanisms, Spread, and Evolution of Antimicrobial Resistance

edited by Ning Dong and Yarong Wu

submission deadline 31 May 2026 | 1 articles | Viewed by 2157 | Submission Open

Keywords: ESKAPE pathogens; antimicrobial resistance; genomic epidemiology

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Antimicrobial Resistance in Veterinary Pathogens: Phenotypic Surveillance, Genomic Epidemiology, and Control Measures

edited by

Ádám Kerek

and

Ákos Jerzsele

submission deadline 31 May 2026 | 2 articles | Viewed by 2078 | Submission Open

Keywords: antimicrobial resistance; veterinary pathogens; phenotypic surveillance; genomic epidemiology; resistance genes; alternative control strategies; One Health

Resistance and Evolving Biology in Mycobacteria: Multidisciplinarity as a Contemporary Approach

edited by

Irena Arandjelovic

and Dragana Vukovic

submission deadline 31 May 2026 | 1 articles | Viewed by 1719 | Submission Open

Keywords: tuberculosis; drug resistance; evolutionary biology; pathogen-host interactions

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Antimicrobial Activity of Medical Materials, 2nd Edition

edited by Tânia Grainha and Susana Lopes

submission deadline 31 May 2026 | 1 articles | Viewed by 664 | Submission Open

Keywords: antimicrobial surfaces; copper; silver; surface functionalization/modifications; biofilm prevention; medical textiles; efficiency

(This special issue belongs to the Section Antimicrobial Materials and Surfaces)

The Use of Systemic and Topical Antibiotics in Dentistry: Challenges and Future Perspectives

edited by

Sigrun Eick

and

Valentino Natoli

submission deadline 31 May 2026 | Viewed by 410 | Submission Open

Keywords: antibiotics; apical abscess; apical periodontitis; endodontic infection; periapical disease; mouth diseases; topical antibiotics; antimicrobial approaches

Antimicrobial Resistance in Animals and Animal Products and Its Environmental Transmission Aspects, Second Edition

edited by

Nikolaos Solomakos

Thomai Lazou

and

Andreana Pexara

submission deadline 31 May 2026 | Viewed by 278 | Submission Open

Keywords: antimicrobial resistance; One Health; AMR dissemination in the environment; antibiotics in animals; foodborne pathogens; animal products

(This special issue belongs to the Section Antibiotics in Animal Health)

Antimicrobial Nanomaterials: Advances, Challenges, and Future Perspectives

edited by

Nuno Miguel Figueiredo

and Daniela Santo

submission deadline 31 May 2026 | Viewed by 257 | Submission Open

Keywords: antimicrobial nanomaterials; metal and metal oxide nanoparticles and nanocomposites; carbon-based nanomaterials; polymeric and hybrid nanostructures; photocatalytic nanomaterials; multifunctional antimicrobial coatings; antimicrobial mechanisms of action; biocompatibility and toxicity

(This special issue belongs to the Section Antimicrobial Materials and Surfaces)

Antimicrobial Therapeutics for Bone and Periprosthetic Joint Infection, 2nd Edition

edited by

Éric M. Senneville

submission deadline 31 May 2026 | Viewed by 224 | Submission Open

Keywords: osteomyelitis; diabetic foot osteomyelitis; periprosthetic joint infections; antimicrobial therapy; recurrence; persistence; biofilm

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

The Antimicrobial Activity of Metal-Based Nanoparticles

edited by Suzan Pantaroto de Vasconcellos

submission deadline 10 Jun 2026 | 2 articles | Viewed by 4831 | Submission Open

Keywords: metal-nanoparticle; microbicide; virucide; phytopathogens; disinfectant; synthesis; antibiotic resistance

(This special issue belongs to the Section Antimicrobial Materials and Surfaces)

Antimicrobial Resistance in Veterinary Science, 2nd Edition

edited by

Nahla O. Eltai

submission deadline 15 Jun 2026 | 8 articles | Viewed by 13962 | Submission Open

Keywords: AMR; veterinary animals; farm animals; food animals; wild animals; resistance

(This special issue belongs to the Section Antibiotics in Animal Health)

New Insights Toward the Development of Novel Inhibitors of S. aureus and P. aeruginosa Factors

edited by Que Chi Truong-Bolduc, Leon G. Leanse,

Hidemasa Nakaminami

and

Chun-Hsing Liao

submission deadline 15 Jun 2026 | 4 articles | Viewed by 5927 | Submission Open

Keywords: MSSA; MRSA; P. aeruginosa; coinfection; antibiotic resistance; therapeutic strategy; anti-virulence; quorum-sensing; virulence factors; biofilms

(This special issue belongs to the Section Novel Antimicrobial Agents)

Antimicrobial Therapy in Oral Diseases, 2nd Edition

edited by

Alexandra Roman

and

Andrada Soanca

submission deadline 15 Jun 2026 | Viewed by 207 | Submission Open

Keywords: oral; antibiotic; antiseptic; tooth; periodontium; dental caries; implant; healing; cell; biomaterials; periodontitis; biocompatibility; toxicity; periodontology; periodontal pocket; bacteria; nonsurgical treatment; oral surgery; clinical trial

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Antimicrobials Agents: Latest Advances and Prospects

edited by

Marius Stefan

submission deadline 30 Jun 2026 | 8 articles | Viewed by 47690 | Submission Open

Keywords: multidrug-resistant pathogens; infectious diseases; antibiotic resistance; new antimicrobials; drug development; antimicrobial activity; structure– activity relationship (SAR); antimicrobial therapy

(This special issue belongs to the Section Novel Antimicrobial Agents)

The Spread of Antibiotic Resistance in Natural Environments

edited by

Daniel Gyamfi Amoako

submission deadline 30 Jun 2026 | 7 articles | Viewed by 37105 | Submission Open

Keywords: antibiotic resistance dissemination; antibiotic pollution; environmental adaptation; mobile genetic elements; ecological impact; environmental microbiome; resistance gene transfer; resistance hotspot; genomic landscape; One Health approach; emerging contaminants; bioinformatics in environmental genomics

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Diagnosis and Antimicrobial Therapy of Osteoarticular Infection

edited by Janet D. Conway

submission deadline 30 Jun 2026 | 6 articles | Viewed by 28335 | Submission Open

Keywords: bone infection; joint infection; periprosthetic joint infection; orthopaedic infection; orthopedic infection

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Comprehensively Addressing Antimicrobial Resistance, Improving Food Safety and Achieving the One Health Goals: Global Challenges

edited by

Vladimir Kurćubić

, Pavle Mašković,

Milan N. Mitić

and

Nikola Stanišić

submission deadline 30 Jun 2026 | 5 articles | Viewed by 12846 | Submission Open

Keywords: antimicrobial resistance (AMR); food safety; foodborne pathogens; antibiotic residues; natural antimicrobials; one health

Diagnostics, Antibiotic Usage and Surgery Related Techniques in Prevention and Treatment of Prosthetic Joint and Implant Related Infections

edited by

Bernd Fink

and

Steffen Ruchholtz

submission deadline 30 Jun 2026 | 5 articles | Viewed by 12659 | Submission Open

Keywords: periprosthetic joint infection; implant-related infection; antibiotics; spacer; diagnosis; septic revision arthroplasty; irrigation; debridement

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Bacteriophages and Phage-Derived Enzymes as Antibacterial Agents

edited by

Grzegorz Wegrzyn

submission deadline 30 Jun 2026 | 4 articles | Viewed by 10967 | Submission Open

Keywords: phage therapy; lytic bacteriophages; phage-derived enzymes; antibiotic resistance

(This special issue belongs to the Section Bacteriophages)

Discovery and Development of Novel Antibacterial Agents—2nd Edition

edited by

Kui Zhu

submission deadline 30 Jun 2026 | 4 articles | Viewed by 10378 | Submission Open

Keywords: antibiotic discovery; antibacterial target; mode of action; natural product

(This special issue belongs to the Section Novel Antimicrobial Agents)

The Issue of Multidrug-Resistant Pathogens in Nosocomial Infections, 2nd Edition

edited by

Alberto Enrico Maraolo

submission deadline 30 Jun 2026 | 4 articles | Viewed by 9505 | Submission Open

Keywords: antimicrobial resistance; MDR; XDR; DTR; nosocomial infections

Pharmacokinetics and Pharmacodynamics of Antibacterial and Antivirulence Drugs, 2nd Edition

edited by

Takahisa Yano

submission deadline 30 Jun 2026 | 4 articles | Viewed by 9399 | Submission Open

Keywords: pharmacokinetics; pharmacodynamics; clinical trials; antimicrobial resistance; antibacterials; antivirulence drugs; pathoblockers; antimicrobial use; drug utilization studies; PK/PD modeling; PBPK-modeling

(This special issue belongs to the Section Pharmacokinetics and Pharmacodynamics of Drugs)

Small Intestinal Bacterial Overgrowth and Antimicrobials

edited by

Mislav Radić

and

Andrej Belančić

submission deadline 30 Jun 2026 | 1 articles | Viewed by 8860 | Submission Open

Keywords: small intestine bacterial overgrowth; antibiotics; probiotics; gut microbiome

(This special issue belongs to the Section Novel Antimicrobial Agents)

Antibiotic Utilization and Resistance Patterns in Perioperative and Surgical Settings

edited by Massimo Sartelli

submission deadline 30 Jun 2026 | 1 articles | Viewed by 7104 | Submission Open

Keywords: antimicrobial resistance; surgical antibiotic prophylaxis; antibiotic therapy

A Themed Issue in Honor of Dr. Lynne V. McFarland—Clostridioides difficile Infection and Impact of Antibiotics on the Intestinal Microbiome

edited by Ellie J. C. Goldstein and Shan Goh

submission deadline 30 Jun 2026 | 3 articles | Viewed by 6873 | Submission Open

Keywords: Clostridioides difficile infections; intestinal microbiome; infection control practices; antibiotic complications; probiotics; live biotherapeutic products; treatment; prevention

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Antibiotics: Utilization, Resistance, and Infection Prevention

edited by

Tafadzwa Dzinamarira

and

Claude Mambo Muvunyi

submission deadline 30 Jun 2026 | 1 articles | Viewed by 6729 | Submission Open

Keywords: antibiotic resistance; antimicrobial stewardship; infection prevention; antibiotic stewardship programs; antimicrobial resistance mechanisms; infection control; rapid diagnostics; public health and AMR; antibiotic alternatives; surveillance systems

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Bacterial Extracellular Vesicles: Vehicles for Pathogenesis and Antibiotic Resistance

edited by

Eva Sapi

submission deadline 30 Jun 2026 | 3 articles | Viewed by 4978 | Submission Open

Keywords: bacterial extracellular vesicles (BEVs); outer membrane vesicles (OMVs); antibiotic resistance; pathogenesis; host-pathogen interaction

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Antibacterial Treatment in Periodontal and Endodontic Therapy, 3rd Edition

edited by

Andreas Braun

and

Felix Krause

submission deadline 30 Jun 2026 | 5 articles | Viewed by 4975 | Submission Open

Keywords: periodontology; endodontology; cariology; photodynamics; laser dentistry

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