Antibacterial Treatment in Periodontal and Endodontic Therapy, 3rd Edition

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1845

Special Issue Editors


E-Mail Website
Guest Editor
Clinic for Operative Dentistry, Periodontology and Preventive Dentistry, RWTH Aachen University, 52074 Aachen, Germany
Interests: periodontology; endodontology; cariology; photodynamics; laser dentistry
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Clinic for Operative Dentistry, Periodontology and Preventive Dentistry, RWTH Aachen University, 52074 Aachen, Germany
Interests: periodontology; endodontology; cariology; photodynamics; laser dentistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We have published two successful editions of the Special Issue “Antibacterial Treatment in Periodontal and Endodontic Therapy", and this encourages us to open a third edition focused on the same topic.

Diseases in the oral cavity are usually associated with the formation of a bacterial biofilm, the removal of which forms the basis of systematic therapeutic measures. Treatment in periodontology and endodontics also aims to remove such biofilms. In addition to local antimicrobial approaches, the use of an antibiotic that is effective against the individual bacterial spectrum may be necessary in some cases in order to control disease processes and prevent the spread of inflammatory processes to other areas of the body. However, the possible side effects on the organism as a whole or even the development of resistance must be taken into account. Alternative approaches such as antimicrobial photochemical, photodynamic and photothermal methods also utilise laser energy to achieve a toxic effect on microorganisms. In the treatment of periodontitis of different stages and severity as well as endodontic therapy measures, adjunctive applications to conventional approaches show promising results and could therefore represent a useful addition to existing periodontal and endodontic antimicrobial treatment approaches.

Volume 3 of this Special Issue aims to contain current studies on the use of antimicrobial therapy approaches in periodontal and endodontic therapy.

Prof. Dr. Andreas Braun
Prof. Dr. Felix Krause
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • periodontology
  • endodontology
  • cariology
  • photodynamics
  • laser dentistry

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Related Special Issues

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

17 pages, 7634 KB  
Article
CLSM-Guided Imaging to Visualize the Depth of Effective Disinfection in Endodontics
by Rebecca Mattern, Sarah Böcher, Gerhard Müller-Newen, Georg Conrads, Johannes-Simon Wenzler and Andreas Braun
Antibiotics 2025, 14(12), 1201; https://doi.org/10.3390/antibiotics14121201 - 1 Dec 2025
Viewed by 260
Abstract
Background/Objectives: Important goals of endodontic treatment procedures are to effectively eliminate microorganisms from the root canal system and prevent reinfection. Despite advances in techniques, these goals continue to be difficult to achieve due to the complex anatomy of the root canal system and [...] Read more.
Background/Objectives: Important goals of endodontic treatment procedures are to effectively eliminate microorganisms from the root canal system and prevent reinfection. Despite advances in techniques, these goals continue to be difficult to achieve due to the complex anatomy of the root canal system and bacterial invasion into the dentinal tubules of the surrounding root dentin. This pilot study aimed to refine a confocal laser scanning microscopy (CLSM) model with LIVE/DEAD staining to quantitatively assess the depth of effective disinfection by endodontic disinfection measures. Methods: Thirty caries-free human teeth underwent standardized chemo-mechanical root canal preparation and were inoculated with Enterococcus faecalis. Following treatment, CLSM-guided imaging with LIVE/DEAD staining allowed for differentiation between vital and dead bacteria and quantification of the depth of effective disinfection. Results: An average depth of bacterial eradication of 450 µm for conventional and 520 µm for sonically activated irrigation (EDDY) could be observed with significant differences (p < 0.05) in the coronal and medial positions. Conclusions: The results indicated that sonically activated irrigation (EDDY) provided a more homogeneous (omnidirectional) irrigation pattern compared to conventional irrigation. The study highlights the importance of effective disinfection strategies in endodontics, emphasizing the need for further research on the depth of effective disinfection of endodontic disinfection measures and the optimization of disinfection protocols. Full article
Show Figures

Figure 1

14 pages, 1495 KB  
Article
Assessment of Oral Microbial Viability by 2,6-Dichlorophenolindophenol a Redox Agent
by Prem K. Sreenivasan and Violet I. Haraszthy
Antibiotics 2025, 14(6), 590; https://doi.org/10.3390/antibiotics14060590 - 7 Jun 2025
Viewed by 1186
Abstract
Background/Objectives: This investigation evaluated 2,6-Dichlorophenolindophenol (DCIP), a redox dye, as a colorimetric reagent for rapid quantification of oral bacteria and examined the antimicrobial effects of oral hygiene formulations. Methods/Results: Viable microbial cells reduce DCIP, resulting in a loss of its blue color which [...] Read more.
Background/Objectives: This investigation evaluated 2,6-Dichlorophenolindophenol (DCIP), a redox dye, as a colorimetric reagent for rapid quantification of oral bacteria and examined the antimicrobial effects of oral hygiene formulations. Methods/Results: Viable microbial cells reduce DCIP, resulting in a loss of its blue color which can be measured spectrophotometrically. Strains of Actinomyces viscosus, Veillonella atypica, Aggregatibacter actinomycetemcomitans, Streptococcus mutans and Candida albicans grown in the laboratory reduced DCIP. Significant correlations between increasing viable plate counts and DCIP reduction were noted for strains of oral organisms. Intact microbial cells reduced DCIP, with insignificant reductions observed by spent microbial media or bacteria free culture media. Organisms inactivated by either heat or cold demonstrated significantly lower DCIP reduction in comparison to metabolically intact organisms grown under optimal conditions. Conclusions: DCIP reduction provided a rapid and accurate method to evaluate antimicrobial effects of clinical proven mouthwashes formulated with cetylpyridinium chloride or chlorhexidine and toothpastes for a range of oral bacteria. Together, these results identify a rapid, low-cost method using common laboratory equipment to enumerate oral organisms with a visual outcome. Full article
Show Figures

Figure 1

Back to TopTop