ESKAPEE: Mechanisms, Spread, and Evolution of Antimicrobial Resistance
A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Mechanism and Evolution of Antibiotic Resistance".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 65
Special Issue Editors
Interests: antimicrobial resistance; genomic epidemiology of infectious agents; One Health; drug discovery
Interests: population genomics of bacteria; bacterial evolution
Special Issue Information
Dear Colleagues,
ESKAPE consists of six bacterial pathogens that contribute to a considerable amount of antibiotic-resistant infections identified in clinical medicine, including Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. These highly virulent and antibiotic-resistant ESKAPE pathogens are the leading cause of nosocomial infection around the globe, particularly among critically ill and immunocompromised individuals. Their capacity to harbor intrinsic or acquired resistance determinants under both natural and anthropogenic selective pressures has led to the widespread emergence of multidrug-resistant strains, enabling these bacteria to evade or withstand conventional antibiotic therapies. Consequently, infections caused by ESKAPE pathogens are frequently associated with limited treatment options, higher risks of therapeutic failure, and increased morbidity and mortality. The growing burden of these infections imposes significant challenges on healthcare systems, necessitating urgent efforts to develop more effective strategies for prevention, diagnosis, and treatment.
This Special Issue aims to provide an in-depth discussion of the mechanisms of resistance among ESKAPE pathogens and the spread and evolution of such pathogens, integrating insights from molecular microbiology, evolutionary biology, and epidemiology. It critically examines the genetic determinants, biochemical pathways, and adaptive strategies that underpin the emergence and dissemination of antimicrobial resistance. Through rigorous scientific analysis, this collection of articles hopes to enhance the understanding of the epidemiological dynamics of ESKAPE pathogens and to inform effective clinical practices and public health policies.
Dr. Ning Dong
Dr. Yarong Wu
Guest Editors
Manuscript Submission Information
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Keywords
- ESKAPE pathogens
- antimicrobial resistance
- genomic epidemiology
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