The Antimicrobial Activity of Metal-Based Nanoparticles

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antimicrobial Materials and Surfaces".

Deadline for manuscript submissions: 10 June 2026 | Viewed by 2324

Special Issue Editor


E-Mail Website
Guest Editor
Multidisciplinary Laboratory on Health and Environment, Federal University of São Paulo, Diadema, Brazil
Interests: antibiotic resistance; metal-based nanoparticles; biocides; antisseptics; bioactives; biopolymers; bioeconomy

Special Issue Information

Dear Colleagues,

Metal-based nanoparticles have been widely used for their versatility for multiple purposes, including environmental, clinical, urban and industrial applications. They can be prepared from many metal sources, as well as via various routes, including chemical, physical–chemical and biogenic synthesis. To identify efficient alternative materials, including nanomaterials and composites, this Special Issue will give specific attention to biocides, antiseptics, pesticides and/or inhibitors preventing microbial growth by using any well-known or completely new mechanisms to promote the deactivation of microbial replication.  Submissions describing metal-based nanoparticles, with effective antiseptic, disinfectant, biocide, or pesticide actions that can be used to reduce the transmission and propagation of microorganisms in different contexts and environments, are especially encouraged.

Dr. Suzan Pantaroto de Vasconcellos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metal-nanoparticle
  • microbicide
  • virucide
  • phytopathogens
  • disinfectant
  • synthesis
  • antibiotic resistance

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Review

9 pages, 924 KB  
Article
Does the Silver Nanoparticles Production Route Affect the Proliferation of Antibiotic Resistance in Soil Ecosystem?
by Jana Sedlakova-Kadukova, Miroslava Sincak and Veronika Demčakova
Antibiotics 2025, 14(1), 15; https://doi.org/10.3390/antibiotics14010015 - 29 Dec 2024
Cited by 1 | Viewed by 1171
Abstract
Introduction: Silver nanoparticles (AgNPs) are widely utilized for their exceptional antimicrobial properties, but concerns persist regarding their environmental impacts, particularly in soil and water ecosystems. This study compared the effects of chemically and biologically synthesized AgNPs and ionic silver on bacterial communities commonly [...] Read more.
Introduction: Silver nanoparticles (AgNPs) are widely utilized for their exceptional antimicrobial properties, but concerns persist regarding their environmental impacts, particularly in soil and water ecosystems. This study compared the effects of chemically and biologically synthesized AgNPs and ionic silver on bacterial communities commonly present in soil and the proliferation of antibiotic resistance in the soil ecosystem. Results and Discussion: Biologically synthesized AgNPs exhibited the strongest antimicrobial activity, significantly reducing bacterial populations within a day, and demonstrated minimal impacts on the development of antibiotic resistance in long-term. Notably, resistance to ampicillin was lower by 72% in comparison with a control after 90 days in the presence of biologically produced AgNPs, while resistance to tetracycline and kanamycin dropped to nearly negligible levels. In contrast, chemically synthesized AgNPs and ionic silver substantially increased antibiotic resistance in long-term, particularly to ampicillin and chloramphenicol, where resistance levels were 11 to 13 times higher than the controls, respectively. Chemically synthesized AgNPs caused a gradual rise in resistance, while ionic silver induced consistently elevated resistance throughout the study. Conclusions: These differences highlight the complex interplay between nanoparticle composition and bacterial adaptation. The findings suggest that biologically synthesized AgNPs are a promising environmentally friendly alternative, reducing bacterial resistance and mitigating the risks associated with silver-induced antibiotic resistance in soil ecosystems. They have greater potential for sustainable applications while addressing critical concerns about antimicrobial resistance and environmental safety. Full article
(This article belongs to the Special Issue The Antimicrobial Activity of Metal-Based Nanoparticles)
Show Figures

Figure 1

Review

Jump to: Research

30 pages, 3423 KB  
Review
Harnessing Copper Nanoparticles for Antimicrobial Applications: Advances and Challenges
by Diogo S. Pellosi, Giovanna S. M. Paiva, Vitor G. Vital, Adriano L. Mendes, Nubia G. Santos, Fernanda K. Kuriki, Keith D. L. Lira, Giovana C. M. Oliveira, Yasmin R. Gomes, Flavia G. Lobo, Vinicius T. Santos, Marcio R. Silva, Ricardo A. G. Silva and Suzan P. Vasconcellos
Antibiotics 2025, 14(11), 1170; https://doi.org/10.3390/antibiotics14111170 - 20 Nov 2025
Viewed by 786
Abstract
Antimicrobial resistance (AMR) is one of the most significant global health threats of the 21st century, driving the urgent search for alternatives to conventional antibiotics. Copper nanoparticles (CuNPs) have gained attention due to their broad antimicrobial spectrum, cost-effectiveness, and versatile applications in medicine, [...] Read more.
Antimicrobial resistance (AMR) is one of the most significant global health threats of the 21st century, driving the urgent search for alternatives to conventional antibiotics. Copper nanoparticles (CuNPs) have gained attention due to their broad antimicrobial spectrum, cost-effectiveness, and versatile applications in medicine, agriculture, and the food industry. This review provides a systematic overview of the advances in CuNP synthesis, mechanisms of antimicrobial action, biomedical and industrial applications, and associated toxicity issues. A comprehensive literature review was conducted, covering chemical, physical, and biological synthesis strategies; mechanistic studies on microbial inhibition; and experimental reports on biomedical and environmental applications. A comparative analysis revealed opportunities, limitations, and knowledge gaps, with particular emphasis on cytotoxic and ecotoxicological aspects. CuNPs show strong antimicrobial activity against bacteria, fungi, viruses, and multidrug-resistant strains through mechanisms such as reactive oxygen species (ROS) generation, membrane disruption, and DNA/protein interactions. Their use in medical devices, wound dressings, textiles, and packaging materials underlines their application potential. However, cytotoxicity to mammalian cells, ecological risks, and the lack of standardized safety protocols remain critical challenges. Particle size, morphology, and surface chemistry strongly influence both efficacy and toxicity, underlining the importance of controlled synthesis and functionalization. Overall, CuNPs represent a promising strategy to tackle the AMR crisis. Future research should focus on environmentally friendly and surface-modified synthesis approaches, standardized toxicity assessments, and robust regulatory frameworks. By balancing antimicrobial efficacy with biosafety and sustainability, CuNPs could become a transformative platform for clinical, industrial, and environmental applications. Full article
(This article belongs to the Special Issue The Antimicrobial Activity of Metal-Based Nanoparticles)
Show Figures

Figure 1

Back to TopTop