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Antibiotics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Antibiotic Bans and Antimicrobial Resistance: Progress, Challenges, and Future Strategies

edited by

Abdelaziz Ed-Dra

and

Min Yue

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1825 | Submission Open

Keywords: impact of antibiotic bans; antibiotic use; antimicrobial resistance; antibiotic restrictions

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Multidrug-Resistant Pathogens: Genomic Analysis, Resistance Mechanisms, and Clinical Challenges

edited by

Dusan Kekic

and Nemanja Stanisavljevic

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1811 | Submission Open

Keywords: multidrug-resistant pathogens; genomic analysis; antimicrobial resistance; resistance mechanisms; antimicrobial therapy challenges; new antimicrobial drugs and therapies; clinical antimicrobial guidelines

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Repositioning Drugs as a Strategy to Combat Infections

edited by

Hélcio Silva Dos Santos

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1334 | Submission Open

Keywords: repositioning drugs; efflux pump inhibitors; resistant microorganisms; microbial biofilm; antibacterial resistance; antifungal potential

(This special issue belongs to the Section The Global Need for Effective Antibiotics)

Global Strategies for Antimicrobial Stewardship: Insights from WHO and PAHO

edited by

Gustavo Horacio Marin

and Gabriel Levy-Hara

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1269 | Submission Open

Keywords: antimicrobial; stewardship; resistance; consumption; use

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Impact of Antibiotic Residues in Wastewater

edited by Jose Sanchez-Salas

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1040 | Submission Open

Keywords: antibiotic residues; wastewater treatment; environmental antibiotics; pharmaceutical contaminants; antimicrobial resistance

Antibacterial Treatment in Periodontal and Endodontic Therapy, 3rd Edition

edited by

Andreas Braun

and

Felix Krause

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1034 | Submission Open

Keywords: periodontology; endodontology; cariology; photodynamics; laser dentistry

Tackling Multidrug-Resistant Bacteria with New Antimicrobial Strategies

edited by

Vivek Keshri

and

Marc Maresca

submission deadline 31 Dec 2025 | 1 articles | Viewed by 885 | Submission Open

Keywords: multidrug-resistant (MDR); antimicrobial resistance (AMR); novel antibiotics; drug discovery; AMR surveillance; epidemiology

(This special issue belongs to the Section Novel Antimicrobial Agents)

Biofilm-Associated Oral Diseases: Advances in Diagnosis and Challenges in Treatment

edited by

Naiera Zayed

and Cher Farrugia

submission deadline 31 Dec 2025 | 1 articles | Viewed by 856 | Submission Open

Keywords: oral diseases; oral biofilms; host– biofilm interactions; novel antimicrobial strategies; molecular dynamics

(This special issue belongs to the Section Antibiofilm Strategies)

Recent Advances in Efflux Pump Inhibitors and Their Role in Combatting Multidrug Resistance

edited by

László Orosz

and

Spengler Gabriella

submission deadline 31 Dec 2025 | 1 articles | Viewed by 699 | Submission Open

Keywords: multidrug resistance; multidrug efflux pump; efflux pump inhibitor (EPI); accumulation assay; efflux assay; fluorochromes; ethidium bromide; quorum sensing; biofilm

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Antimicrobial Extracts and Compounds Derived from Plants

edited by

Giovanna Simonetti

submission deadline 31 Dec 2025 | 1 articles | Viewed by 633 | Submission Open

Keywords: antibacterial; antifungal; plant extract; plant compounds; antibiotic-resistant strains; virulence factors; synergistic interactions

(This special issue belongs to the Section Plant-Derived Antibiotics)

Foodborne Pathogens: Detection, Resistance Mechanisms, and Control Strategies

edited by

Joana Campos

submission deadline 31 Dec 2025 | 1 articles | Viewed by 626 | Submission Open

Keywords: foodborne pathogens; antimicrobial resistance; rapid detection methods; control strategies; food safety interventions; One Health

Hospital-Associated Infectious Diseases and Antibiotic Therapy

edited by Carola Mauri and

Alessandra Consonni

submission deadline 31 Dec 2025 | 1 articles | Viewed by 618 | Submission Open

Keywords: hospital-associated infectious diseases; epidemiology; treatment; antibiotic stewardship; antimicrobial resistance; multi-drug resistance

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Combatting Dental Infections: Insights into Oral Microbiota and Antibiotic Therapy

edited by

Biao Ren

and

Jaya Seneviratne

submission deadline 31 Dec 2025 | Viewed by 571 | Submission Open

Keywords: oral microbiota; dental diseases; systematic disease; antimicrobial; therapeutic strategies; oral biomaterials; oral probiotics; infectious disease; oral microecology; targets

Gram-Negative Multidrug-Resistant Pathogens and Their Treatment, 2nd Edition

edited by

Ramón Pérez-Tanoira

submission deadline 31 Dec 2025 | 1 articles | Viewed by 571 | Submission Open

Keywords: carbapenemase-producing enterobacteriaceae; multidrug-resistant and extensively drug-resistant Pseudomonas aeruginosa; gram-negative bacteria and antibiotic resistance mechanisms; multidrug resistant; extended-spectrum beta-lactamase (ESBL) producers; antibacterial potential of novel compounds; biofilm inhibition strategies; quorum sensing disruption as a therapeutic approach

Carbapenem-Resistant Acinetobacter baumannii: From Molecular Mechanisms to Clinical Practice

edited by

Antonio Cascio

, David L. Paterson and Luca Pipitò

submission deadline 31 Dec 2025 | Viewed by 370 | Submission Open

Keywords: CRAB; XDR; MDR; Acinetobacter baumannii; antimicrobial resistance; molecular mechanisms; clinical practice

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Natural Compounds as Antimicrobial Agents, 3rd Edition

edited by

Carlos M. Franco

submission deadline 31 Dec 2025 | Viewed by 300 | Submission Open

Keywords: new natural antimicrobial compounds; antimicrobial effects; clinical applications; animal production applications; antifungal properties; antiviral properties; food applications; new formulations; antibacterial mechanisms; antifungal mechanisms; MICs; activity as disinfectants; activity against biofilms; effects on transcriptomics; combination with other antimicrobials; global microbiome changes

(This special issue belongs to the Section Novel Antimicrobial Agents)

ESKAPEE: Mechanisms, Spread, and Evolution of Antimicrobial Resistance

edited by Ning Dong and Yarong Wu

submission deadline 31 Dec 2025 | Viewed by 283 | Submission Open

Keywords: ESKAPE pathogens; antimicrobial resistance; genomic epidemiology

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Global Perspectives on Antimicrobial Stewardship and Food Safety

edited by

Mahmoud Eltholth

submission deadline 31 Dec 2025 | Viewed by 281 | Submission Open

Keywords: antimicrobial resistance; antimicrobial use; food systems; food safety; antimicrobial stewardship

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Antibacterial Utilisation from Different Perspectives: An Effective Tool to Develop and Evaluate Antimicrobial Stewardship Interventions

edited by

Gyöngyvér Soós

and

Ria Benkő

submission deadline 31 Dec 2025 | Viewed by 278 | Submission Open

Keywords: quality of antibiotic use; scale of antibiotic use; pattern of antibiotic use; prevalence of antibiotic use; specific patient populations; safety of use; antibacterial; antivirals; antifungals; anti-TBC

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Global Trends in Antimicrobial Resistance: Epidemiology and Public Health Implications

edited by Louise Teixeira Cerdeira

submission deadline 31 Dec 2025 | Viewed by 269 | Submission Open

Keywords: antimicrobial resistance (AMR); antibiotic misuse; global health; epidemiology; antibiotic stewardship

(This special issue belongs to the Section The Global Need for Effective Antibiotics)

Antimicrobial Resistance in the Wildlife

edited by

Francesca Piras

and Giuliana Siddi

submission deadline 31 Dec 2025 | Viewed by 165 | Submission Open

Keywords: wildlife; wild animal; antimicrobial resistance; transmission; spread; One Health

Antibiotic Resistance in Geriatric Emergency Patients: Challenges and Strategies for Optimal Management

edited by

Sung Jin Bae

and

Dong-Hoon Lee

submission deadline 31 Dec 2025 | Viewed by 161 | Submission Open

Keywords: antibiotic resistance; geriatric emergency medicine; antimicrobial stewardship; multidrug-resistant organisms

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Genomic Insights into Dissemination of Multi-Drug Resistance Pathogens

edited by

Vanessa Silva

and

Gilberto Igrejas

submission deadline 31 Dec 2025 | Viewed by 148 | Submission Open

Keywords: antimicrobial resistance; genomic surveillance; MDR; gene transfer; One Health

Bacterial Extracellular Vesicles: Vehicles for Pathogenesis and Antibiotic Resistance

edited by

Eva Sapi

submission deadline 31 Dec 2025 | Viewed by 147 | Submission Open

Keywords: bacterial extracellular vesicles (BEVs); outer membrane vesicles (OMVs); antibiotic resistance; pathogenesis; host-pathogen interaction

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Advanced Antimicrobial and Bioactive Coatings for Broad-Spectrum Protection

edited by

José Roberto Souza Almeida Leite

and

Andreanne Gomes Vasconcelos

submission deadline 31 Dec 2025 | Viewed by 143 | Submission Open

Keywords: antimicrobial coatings; bioactive surfaces; smart coatings for health; broad-spectrum antimicrobial materials; nanotechnology in antimicrobial coatings; disinfectant-compatible coatings; surface functionalization for microbial control; sustainable antimicrobial strategies

(This special issue belongs to the Section Antimicrobial Materials and Surfaces)

The One Health Perspective: Unveiling Animal and Zoonotic Microbiota in the Frame of Antimicrobial Resistance

edited by

Athina S. Tzora

and

Chrysoula Voidarou

submission deadline 31 Dec 2025 | Viewed by 133 | Submission Open

Keywords: antimicrobial resistance (AMR); One Health approach; veterinary medicine; livestock production; foodborne pathogen reservoirs; epidemiological mapping; resistance mechanisms; microbiome; resistome; intervention

(This special issue belongs to the Section Antibiotics in Animal Health)

Advances in Antimicrobial Compounds: Exploring Natural, Synthetic, and Repositioned Drugs

edited by

Alessia Carocci

and Alexia Barbarossa

submission deadline 31 Dec 2025 | Viewed by 131 | Submission Open

Keywords: antimicrobial compounds; natural products; synthetic agents; drug repositioning; antimicrobial resistance; synergistic approaches; mechanisms of action; drug development

(This special issue belongs to the Section The Global Need for Effective Antibiotics)

Gram-Negative Infections in Humans and Companion Animals: A Global Threat

edited by

Gabriele Meroni

submission deadline 31 Dec 2025 | Viewed by 131 | Submission Open

Keywords: antimicrobial resistance; Gram-negative infections; humans; companion animals; essential oils; nanoparticles; pro-biotics; antimicrobial peptides; genomics; metagenomics

(This special issue belongs to the Section The Global Need for Effective Antibiotics)

Phage Therapy and Antimicrobial Innovation

edited by Ronen Hazan and

Lilach Gavish

submission deadline 31 Dec 2025 | Viewed by 124 | Submission Open

Keywords: antimicrobial resistance (AMR); antimicrobial innovation; phage therapy; phage engineering; synergistic strategies; chronic infections; biofilm; clinical phage microbiology; personalized medicine

(This special issue belongs to the Section Bacteriophages)

Veterinary Antibiotics in Food-Producing Animals: Residue Detection, Risk Assessment and Regulatory Advances

edited by

Liliana J.G. Silva

and Marta Leite

submission deadline 31 Dec 2025 | Viewed by 121 | Submission Open

Keywords: veterinary drugs; analytical chemistry; food safety; risk assessment; regulatory frameworks

(This special issue belongs to the Section Antibiotics in Animal Health)

Antimicrobial Resistance from a One Health Perspective

edited by Flávia L P. C. Pellegrino

submission deadline 31 Dec 2025 | Viewed by 113 | Submission Open

Keywords: antimicrobial resistance mechanisms; bacterial virulence; clonal diversity; molecular epidemiology; antibiotic use; infectious diseases; One Health

Antibiotic Resistance in Agricultural Environments: Emergence, Drivers and Mitigation

edited by

Guyue Cheng

and Juan Wang

submission deadline 31 Dec 2025 | Viewed by 105 | Submission Open

Keywords: antibiotic resistance (AMR); animal husbandry; environmental resistome; livestock microbiome; co-selection; agricultural environments; One Health; antibiotic resistance genes (ARGs); heavy metals; selective pressures

(This special issue belongs to the Section Antibiotics in Animal Health)

Managing Staphylococcus spp. Infections: Current Practices and Future Directions

edited by

Nikolaos Giormezis

submission deadline 31 Dec 2025 | Viewed by 88 | Submission Open

Keywords: Staphylococcus aureus; coagulase-negative staphylococci; novel antibiotics; novel therapies; bacteriophages; biofilm disruption

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Innovative Treatments for Hospital-Acquired Multidrug-Resistant Bacterial Infections

edited by

Lucas de Paula Ramos

Cristina Pacheco-Soares

, Hugo Vigerelli and Florence Carrouel

submission deadline 31 Dec 2025 | Viewed by 76 | Submission Open

Keywords: antimicrobial agents; gram-negative aerobic rods and cocci; vancomycin resistance; cross-infection; infection control

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Biofilms and Implantable Device-Related Infections

edited by

Felipe Francisco Tuon

submission deadline 31 Dec 2025 | Viewed by 75 | Submission Open

Keywords: biofilm formation; implant-associated infections; medical devices; antimicrobial resistance; infection prevention

Epidemiology, Impact and Mitigation of Antimicrobial Resistance in Veterinary Medicine, 3rd Edition

edited by

Robin Temmerman

submission deadline 31 Dec 2025 | Viewed by 64 | Submission Open

Keywords: antimicrobial resistance; veterinary medicine; antibiotics; One Health; epidemiology

New Insights Toward the Development of Novel Inhibitors of S. aureus and P. aeruginosa Factors

edited by Que Chi Truong-Bolduc, Leon G. Leanse,

Hidemasa Nakaminami

and

Chun-Hsing Liao

submission deadline 31 Dec 2025 | Viewed by 61 | Submission Open

Keywords: MSSA; MRSA; P. aeruginosa; coinfection; antibiotic resistance; therapeutic strategy; anti-virulence; quorum-sensing; virulence factors; biofilms

(This special issue belongs to the Section Novel Antimicrobial Agents)

Antimicrobial Resistance Surveillance Methods: Challenges and Opportunities

edited by Samo Jeverica

submission deadline 31 Dec 2025 | Viewed by 50 | Submission Open

Keywords: antimicrobial resistance; AMR surveillance; One Health; infectious diseases; global health

Machine Learning for Antimicrobial Resistance Prediction, 2nd Edition

edited by

Asad Mustafa Karim

submission deadline 10 Jan 2026 | 1 articles | Viewed by 3339 | Submission Open

Keywords: antimicrobial resistance prediction; artificial intelligence; machine learning; infectious diseases

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Rational Use of Antibiotics in Veterinary Medicine

edited by

JeongWoo Kang

submission deadline 15 Jan 2026 | 2 articles | Viewed by 6341 | Submission Open

Keywords: good manufacturing practice (GMP) in antibiotic production; research and systems in antibiotic quality control; consequences of improper antibiotic use; antibiotic stewardship programs; antibiotic resistance management

(This special issue belongs to the Section Antibiotics in Animal Health)

Antibiotic Resistance: The Role of Aquatic Environments

edited by

Jason W. Marion

and Matthew D. Stocker

submission deadline 15 Jan 2026 | 2 articles | Viewed by 2188 | Submission Open

Keywords: antibiotic resistance; water; wastewater; One Health; antibiotic misuse; antimicrobial resistance genes; microbiology; fecal indicator bacteria; mobile genetic elements; resistome; pollution; environment; water bodies; water treatment; waterborne disease; public health; risk assessment; sanitation; hygiene; aquatic environments

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

The Discovery of Novel beta-Lactams and beta-Lactamase Inhibitors

edited by

Caitlyn Thomas

and

Juhee Ahn

submission deadline 15 Jan 2026 | Viewed by 155 | Submission Open

Keywords: antibiotic resistance; β -lactam antibiotics; β -lactamase inhibitors; drug discovery; metallo-β -lactamases; serine-β -lactamase

Strategies for Combating Antibiotic Resistance: From Mechanisms to Drug Discovery

edited by Angel Leon-Buitimea

submission deadline 15 Jan 2026 | Viewed by 121 | Submission Open

Keywords: antibiotic resistance; clinically relevant bacteria; multidrug-resistant bacteria; pan-drug-resistant bacteria; drug discovery; combinatorial treatments

Molecular and Therapeutic Insights into Antimicrobial Candidates and Antibiotics

edited by

Fabio Aguiar Alves

submission deadline 15 Jan 2026 | Viewed by 82 | Submission Open

Keywords: antimicrobial resistance; novel antimicrobial agents; molecular mechanisms; therapeutic applications

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Advances in Antimicrobial Treatment of Periodontitis

edited by

Thomas E. Rams

submission deadline 15 Jan 2026 | Viewed by 54 | Submission Open

Keywords: periodontitis; periodontal chemotherapy; anti-infective periodontal therapy; antibiotic therapy

New Insights into Prevention, Diagnosis, and Treatment of Neonatal Sepsis and Short- and Long-Term Outcomes

edited by

Vasilios Giapros

Dimitrios Rallis

and Maria Baltogianni

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3539 | Submission Open

Keywords: neonate; sepsis; early sepsis; late sepsis; antibiotic resistance; multiple resistance antibiotics; antibiotics stewardship

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Design and Synthesis of Novel Antibiotics, 2nd Edition

edited by Kenneth Ikenna Onyedibe

submission deadline 20 Jan 2026 | Viewed by 110 | Submission Open

Keywords: drug discovery; antimicrobial modes of action; antimicrobial resistance; structural characterization; antimicrobial activity

(This special issue belongs to the Section Novel Antimicrobial Agents)

Antibiotic Use and Stewardship in Settings Outside of Acute Hospitals

edited by Monsey McLeod and Naomi Fleming

submission deadline 30 Jan 2026 | Viewed by 68 | Submission Open

Keywords: antimicrobial stewardship; antibiotic use; community; primary care; mental health; local authority; care home; public; health and justice; dental

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Discovery and Synthesis of Antimicrobial Compounds Against Multidrug Resistance

edited by

Anita Cohen

submission deadline 31 Jan 2026 | 4 articles | Viewed by 38829 | Submission Open

Keywords: antimicrobial resistance; medicinal chemistry; (pre)clinical development; intrinsic/synergistic activity; innovative antibiotic treatment; antimicrobial drug-candidate; new and repurposed medicines

(This special issue belongs to the Section Novel Antimicrobial Agents)

Antibiotic Resistance in Wastewater Treatment Plants

edited by Qingbin Yuan

submission deadline 31 Jan 2026 | 5 articles | Viewed by 5182 | Submission Open

Keywords: antibiotic resistance genes; wastewater treatment; one health; distribution and removal of ARGs; horizontal gene transfer

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

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