Evidence in Antibiotic Mastitis Therapy

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotics in Animal Health".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 488

Special Issue Editors


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Guest Editor
Department of Microbiology, Faculty of Mechanical and Bioprocess Engineering, University of Applied Sciences and Arts, 30453 Hannover, Germany
Interests: animal science; mastitis; Staphylococcus aureus; bovine mastitis; antimicrobials
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Guest Editor
Department of Veterinary Medicine and Animal Science, University of Milan, Via dell'Università 1, 26900 Lodi, Italy
Interests: bovine mastitis; risk factors; treatment; prevention; therapy worthiness
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In dairy cows, around 70% of the antibiotic doses used treat mastitis. Despite extensive research, many questions regarding optimised antibiotic therapy remain unanswered. They concern fundamental aspects such as selecting cases to be treated with antibiotics and their identification under practical conditions, as well as questions about active substances, treatment durations, dose regimes and resistance. This Special Issue will compile new knowledge to help implement targeted and efficient therapy in practice, taking into account aspects of husbandry, the animals to be treated, and the microorganisms, as well as pharmacological aspects of therapy. We welcome contributions that will further develop antibiotic mastitis therapy.

Dr. Volker Krömker
Dr. Paolo Moroni
Guest Editors

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Keywords

  • antibiotic mastitis treatment
  • targeted
  • selective
  • pathogens
  • mastitis history
  • new infections

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Published Papers (1 paper)

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Review

19 pages, 1127 KiB  
Review
Antibiotic Treatment vs. Non-Antibiotic Treatment in Bovine Clinical Mastitis During Lactation with Mild and Moderate Severity
by Franziska Nankemann, Stefanie Leimbach, Julia Nitz, Anne Tellen, Nicole Wente, Yanchao Zhang, Doris Klocke, Isabel Krebs, Stephanie Müller, Sabrina Teich, Jensine Wilm, Pauline Katthöfer, Jan Kortstegge and Volker Krömker
Antibiotics 2025, 14(7), 702; https://doi.org/10.3390/antibiotics14070702 - 12 Jul 2025
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Abstract
Background/Objectives: This review aimed to compare the efficacy of antibiotic treatment vs. non-antibiotic treatment in mild and moderate clinical mastitis in lactating dairy cows, categorized by the causative pathogen. Methods: The initial systematic review plan, which resulted in only four relevant articles, was [...] Read more.
Background/Objectives: This review aimed to compare the efficacy of antibiotic treatment vs. non-antibiotic treatment in mild and moderate clinical mastitis in lactating dairy cows, categorized by the causative pathogen. Methods: The initial systematic review plan, which resulted in only four relevant articles, was altered due to limited available studies and significant heterogeneity among them. Consequently, five additional articles, closely meeting our criteria with minor differences, were included to ensure comprehensive analysis, resulting in nine included articles. Due to these pragmatic constraints, this review represents a hybrid between a systematic and a narrative review. The outcome of interest was the bacteriological cure (BC). Results: The findings revealed that antibiotic treatment resulted in improved BC rates for cases caused by Streptococci. For cases caused by Escherichia (E.) coli, antibiotic therapy showed no significant improvement in BC rates compared to non-antibiotic treatment, suggesting that antibiotics may be often unnecessary for these cases due to self-limiting tendencies. However, severe E. coli mastitis warrants systemic antibiotic treatment due to potentially life-threatening complications. Klebsiella spp. mastitis showed better cure rates with antibiotic therapy. Conclusions: This study underscores the importance of regular pathogen diagnostics to guide appropriate treatment, advocating for the use of on-farm rapid tests to reduce unnecessary antibiotic use while ensuring effective treatment outcomes. Full article
(This article belongs to the Special Issue Evidence in Antibiotic Mastitis Therapy)
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