Strategies for the Design of Hybrid-Based Antimicrobial Compounds
A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Novel Antimicrobial Agents".
Deadline for manuscript submissions: 20 September 2025 | Viewed by 852
Special Issue Editors
Interests: natural product chemistry; organic synthesis; hybrid compounds; antimicrobial compounds; anticancer compounds; phytochemicals and their derivatives; medicinal chemistry
Interests: polymers; nanoparticles; wound dressings; skin regeneration; nanofibers; membranes; hydrogels; essential oils; anticancer drugs; antimalarials
Special Issues, Collections and Topics in MDPI journals
Interests: polymer-based materials; wound dressings; drug delivery systems; nanocarriers; drug discovery and design; organic synthesis of drug molecules (antimalarials, antimicrobials, anticancer)
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The need for innovative therapeutic strategies to enhance patient outcomes has increased due to the rising threat of multidrug-resistant (MDR) pathogens. In the design of antimicrobial drugs, hybrid molecules containing two or more pharmacophores have emerged as a promising drug design strategy to overcome the issue of MDR. These hybrid molecules display high potential to offer better pharmacokinetic characteristics, suppress resistance mechanisms, and enhance therapeutic outcomes.
The aim of this Special Issue is to provide a platform for researchers working on the synthesis, pharmacological evaluation, and mechanistic investigations of synthetic or plant-based hybrid antimicrobial drugs to publish their findings. Authors are invited to contribute their original research articles, reviews, and communications focusing on innovative hybrid molecules targeting bacterial, fungal, and viral infections.
Dr. Vuyolwethu Khwaza
Dr. Sibusiso Alven
Prof. Dr. Blessing Atim Aderibigbe
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.
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Keywords
- hybrid compounds
- antimicrobial agents
- antibacterial agents
- antifungal activity
- antiviral activity
- in vitro evaluation
- structure–activity relationship (SAR)
- bioactive molecules
- nanoformulations
- targeted drug delivery
- pharmacological screening
- clinical studies
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