Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cancer and Immune System Interactions submission deadline 16 Dec 2025 | Viewed by 197
Keywords: cancer immunology; tumor microenvironment; immune evasion; immunotherapy; tumor– immune interactions; immune checkpoint regulation; translational oncology
(This special issue belongs to the Section Cell Microenvironment)
Molecular Mechanisms of Cognitive Function and Dysfunction submission deadline 20 Dec 2025 | 2 articles | Viewed by 6364 | Submission Open
Keywords: cognition; neurodevelopment; neurotransmission; molecular mecanisms; signaling; disorders; therapy
(This special issue belongs to the Section Cellular Neuroscience)
Physiology of Telocytes
edited by and Mihail E. Hinescu
submission deadline 20 Dec 2025 | 1 articles | Viewed by 5121 | Submission Open
Keywords: telocytes; telopodes; physiology; pathology; tissue homeostasis; regenerative medicine
(This special issue belongs to the Section Cellular Pathology)
Metabolic Hallmarks in Cancer
edited by , Ubaldo Martinez-Outshoorn and Marta Mauro-Lizcano
submission deadline 20 Dec 2025 | 2 articles | Viewed by 3683 | Submission Open
Keywords: cancer; metabolic reprogramming; metabolic adaptation; cancer energy metabolism; glycolysis; the Warburg effect; the reverse Warburg effect; glutamine addiction; the pentose phosphate pathway; cellular and molecular mechanisms; tumor microenvironment; novel therapeutic interventions
(This special issue belongs to the Section Cellular Metabolism)
Advances in Human Pluripotent Stem Cells submission deadline 20 Dec 2025 | 3 articles | Viewed by 3330 | Submission Open
Keywords: human pluripotent stem cells; embryonic stem cells; induced pluripotent stem cells  
(This special issue belongs to the Section Stem Cells)
Microglial Functions in Neurodegenerative Diseases: In Search of Potential Therapeutic Targets
edited by and María Martín Estebané
submission deadline 20 Dec 2025 | Viewed by 346 | Submission Open
Keywords: microglia; inflammation; neural damage; mitochondria; potential targets
(This special issue belongs to the Section Cellular Aging)
Advanced Research on Genomic Instability and Gene Expression in Developmental Disorders
edited by
submission deadline 20 Dec 2025 | Viewed by 274 | Submission Open
Keywords: development; neurological disease; cancer; genetic; epigenetic
Targeting Thermogenesis in Metabolic Disorders: Novel Pharmacological and Lifestyle Interventions
edited by
submission deadline 20 Dec 2025 | Viewed by 223 | Submission Open
Keywords: thermogenesis modulation; metabolic disorders; obesity; adipose tissue biology; thermogenic mechanisms; mitochondrial function
Evaluation of the Properties and Effectiveness of Nutritional Factors Using In Vitro Assays, Including Cell Cultures and Organoids
edited by and Sylwia Orczewska-Dudek
submission deadline 20 Dec 2025 | Viewed by 192 | Submission Open
Keywords: cell cultures; organoids; novel nutritional factors; extract; cells viability; cells proliferation; cells cytotoxicity; cell signaling; cells apoptosis; oxidative stress
Acute Myeloid Leukemia: Molecular Mechanisms and Novel Therapies
edited by Xiangguo Shi
submission deadline 20 Dec 2025 | Viewed by 176 | Submission Open
Keywords: acute myeloid leukemia (AML); genomics and epigenetics; therapeutic resistance; metabolic reprogramming; clonal evolution
(This special issue belongs to the Section Cellular Pathology)
Clockwork Cells: Decoding the Language of Cell Cycle Regulators
edited by , Kyung-sang Lee, and
submission deadline 20 Dec 2025 | Viewed by 148 | Submission Open
Keywords: cyclins; cyclin-dependent kinases (CDKs); checkpoints; cell proliferation; mitosis; meiosis
(This special issue belongs to the Section Cell Proliferation and Division)
Cellular Differentiation in Health and Disease
edited by Christine K. C. Loo and
submission deadline 25 Dec 2025 | 1 articles | Viewed by 2626 | Submission Open
Keywords: cellular differentiation; tumour microenvironment; human development; regeneration/healing; cell signaling pathways; tumour differentiation
(This special issue belongs to the Section Cell Microenvironment)
Advances in Molecular Genomics and Pathology of Cancers
edited by
submission deadline 25 Dec 2025 | 1 articles | Viewed by 272 | Submission Open
Keywords: cancer; somatic mutation; short tandem repeat; gene expression; methylation; cf-DNA; single-cell sequencing; NGS; liquid biopsy; precision medicine
(This special issue belongs to the Section Cellular Pathology)
Role of T Cells in Immune Disease Treatment
edited by
submission deadline 25 Dec 2025 | Viewed by 138 | Submission Open
Keywords: autoimmunity; autoimmune diseases; immunotherapy; immune diseases; T cells; B cells; natural killer T cells
(This special issue belongs to the Section Cellular Immunology)
Host Immunity to Bacterial Infections
edited by Karine Gloux
submission deadline 26 Dec 2025 | Viewed by 379 | Submission Open
Keywords: host immune systemsbacterial pathogens; innate and adaptive immune responses; pathogen evasion; bacterial infections
(This special issue belongs to the Section Cellular Immunology)
Epigenetic Regulation in Neuronal Development, Neurodegeneration and Regeneration
edited by
submission deadline 28 Dec 2025 | 1 articles | Viewed by 1843 | Submission Open
Keywords: epigenetic regulation; neuronal development; neuronal regeneration; chromatin remodeling
(This special issue belongs to the Section Cellular Neuroscience)
Fertility Disorders in Testes and Ovaries
edited by and Joanna Kochan
submission deadline 30 Dec 2025 | 1 articles | Viewed by 1699 | Submission Open
Keywords: fertility; ovary; testis; aging; epigenetics; in vitro fertilization; IVF
(This special issue belongs to the Section Tissues and Organs)
Molecular Insights into cAMP/PKA Pathway Regulation in Health and Disease submission deadline 30 Dec 2025 | Viewed by 825 | Submission Open
Keywords: cAMP/PKA signaling; protein kinase A (PKA); cyclic AMP; EPAC; signal transduction; cellular homeostasis; metabolic regulation; disease mechanisms; molecular signaling; therapeutic targets; cross-talk in signaling pathways; protein– protein interactions; post-translational modifications; pharmacological interventions
Emerging Roles of Glial Cells in Human Health and Disease submission deadline 31 Dec 2025 | 10 articles | Viewed by 46819 | Submission Open
Keywords: neurodegenerative diseases; glia cells; astrocyte; microglia; stroke; pain; epilepsy; trauma; demyelinating diseases’ inflammatory diseases; satellite glia; Schwann cells; enteric glia
(This special issue belongs to the Section Cellular Neuroscience)
Gene Therapy for Rare Diseases
edited by
submission deadline 31 Dec 2025 | 7 articles | Viewed by 41706 | Submission Open
Keywords: gene therapy; gene editing; rare diseases; CRISPR; viral vectors; base editing; prime editing
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Understanding Spinal Cord Injury and Repair: From Molecules to Neurocircuits and Multimodal Prostheses
edited by
submission deadline 31 Dec 2025 | 9 articles | Viewed by 26769 | Submission Open
(This special issue belongs to the Section Cellular Neuroscience)
New Insights into Vascular Biology in Health and Disease
edited by Bashir M. Rezk
submission deadline 31 Dec 2025 | 7 articles | Viewed by 19669 | Submission Open
Keywords: vascular diseases; cardiovascular; cancer; hyperhomocyteinemia; endothelial dysfunction; vascular smooth muscle cell; autophagy; alcohol; galectins; angiogenesis; neovascularization
(This special issue belongs to the Section Cells of the Cardiovascular System)
Biological Mechanisms in the Treatment of Neuropsychiatric Diseases
edited by Randall D Marshall and Frank S. Menniti
submission deadline 31 Dec 2025 | 7 articles | Viewed by 18578 | Submission Open
Keywords: neurodevelopmental conditions; rare neurological disease; molecular mechanisms of novel CNS treatments; precision medicine in neuropsychiatry; organoids; molecular mechanisms of effective treatments
(This special issue belongs to the Section Cellular Pathology)
Select Topics in Molecular and Cellular Mechanisms of Mammalian Reproduction
edited by Zhengui Zheng, and Liang Ma
submission deadline 31 Dec 2025 | 7 articles | Viewed by 15137 | Submission Open
Keywords: reproductive organ development; sexual differentiation; reproductive tract function; fertilization; implantation; placentation; parturition; lactation
(This special issue belongs to the Section Reproductive Cells and Development)
Cell Stress and Intervention in Neurological Disease: In Honor of Dr. Jang-Yen Wu for His Long and Distinguished Career in Neuroscience
edited by Howard Prentice and
submission deadline 31 Dec 2025 | 6 articles | Viewed by 9625 | Submission Open
Keywords: neurodegenerative disease; gene therapy; excitotoxicity; calcium dysregulation; Alzheimer’ s disease; stroke; neuroprotection; neurogenesis
(This special issue belongs to the Section Cellular Neuroscience)
Molecular Mechanisms Involved in Musculoskeletal and Other Tissue Injuries and Disruptions—Regenerative Potential of Exercise submission deadline 31 Dec 2025 | 2 articles | Viewed by 9290 | Submission Open
Keywords: tissue injury; tissue regeneration; growth factors; inflammation; oxidative stress; metabolic stress; myokines; adipokines; neurokines; hypertrophy; biochemical pathways; skeletal muscles; liver/hepatic regeneration; brain/neuroplasticity; adipose tissue; varia
(This special issue belongs to the Section Tissues and Organs)
Cellular and Molecular Mechanisms in Oxidative Stress-Related Chronic Diseases
edited by Sara Spinelli, and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 8592 | Submission Open
Keywords: aging; age-related diseases; redox system; cellular and molecular mechanisms; oxidative stress biomarkers; synthetic and natural antioxidant molecules
(This special issue belongs to the Section Cellular Pathology)
Ageing and Neurodegenerative Diseases, Second Edition
edited by Feng Wang and
submission deadline 31 Dec 2025 | 3 articles | Viewed by 8374 | Submission Open
Keywords: ageing; miRNAs; lncRNA; circRNAs; diabetes; neurodegenerative disease; insulin signaling
(This special issue belongs to the Section Cellular Pathology)
Signaling Pathways and Mechanisms in Cancer Therapy Resistance submission deadline 31 Dec 2025 | 3 articles | Viewed by 8284 | Submission Open
Keywords: cancer therapy; therapy resistance; molecular mechanisms; cell signaling pathways; genetic and epigenetic modifications; combination therapies
(This special issue belongs to the Section Cellular Pathology)
Redox and Metabolic Profile of Cancer
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 8223 | Submission Open
Keywords: cancer; metabolism; redox biology; redox-metabolic reprogramming; reactive species: oxygen; nitrogen; sulfur; etc; cancer microenvironment; cancer-tissue cooperation; mitochondria
(This special issue belongs to the Section Cellular Metabolism)
Mechanisms of Immune Responses and Therapy submission deadline 31 Dec 2025 | 3 articles | Viewed by 7996 | Submission Open
Keywords: immunity; immune signaling; immune regulation; cellular immunology; molecular immunology; autoimmunity; immune checkpoint; immunotherapy
(This special issue belongs to the Section Cellular Immunology)
Cell Biology: State of the Art and Perspectives in Italy 2025
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 7846 | Submission Open
Keywords: cell biology; physiology; molecular biology
Kynurenic Acid: Unveiling Its Impact on the Brain’s Neurotransmission and Neurological Disorders
edited by Korrapati V. Sathyasaikumar, Sarah Beggiato and
submission deadline 31 Dec 2025 | 3 articles | Viewed by 6956 | Submission Open
Keywords: kynurenic acid; cognition; aging; neuromodulation; neurodegeneration; neurodevelopment; neuroinflammation; tryptophan catabolism
(This special issue belongs to the Section Cell Signaling)
Understanding Aging Mechanisms to Prevent Age-Related Diseases: 2nd Edition
edited by , Pierre Jouanny, and Sonia Hammami
submission deadline 31 Dec 2025 | 3 articles | Viewed by 5260 | Submission Open
Keywords: aging; age-related diseases; pathophysiology; cell mechanisms; therapies; biomarkers
(This special issue belongs to the Section Cellular Aging)
Computational Biophysics in Cellular Biological Systems
edited by and Wenhan Guo
submission deadline 31 Dec 2025 | 2 articles | Viewed by 5057 | Submission Open
Keywords: cellular process; protein– protein interactions; single-cell analysis; drug design; molecular dynamics simulations
(This special issue belongs to the Section Cell Methods)
Organelle Contact and Its Physiological Implications submission deadline 31 Dec 2025 | 1 articles | Viewed by 4658 | Submission Open
Keywords: inter-organelle communication; membrane contact sites; organelle dynamics; mitochondria-associated membranes; cellular homeostasis
Advances in the Cellular and Molecular Mechanisms of Cardiovascular Diseases
edited by and Katie S. Wraith
submission deadline 31 Dec 2025 | 4 articles | Viewed by 3109 | Submission Open
Keywords: thrombosis; smooth muscle; endothelium; atherosclerosis; inflammation
(This special issue belongs to the Section Cells of the Cardiovascular System)
Interplay Between Intestinal Bacteria and Epigenetic Markers in Pathogenesis of Metabolic and Neuropsychiatric Disorders
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 3029 | Submission Open
Keywords: gut microbiome; epigenetic marks; metabolic diseases; neuropsychiatric disorders; probiotics; prebiotics; postbiotics; indole derivatives; epigeneic metabolites
(This special issue belongs to the Section Cellular Neuroscience)
Cellular and Molecular Mechanisms in Neuropsychiatric and Neurological Disorders
edited by Irina Balan
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2962 | Submission Open
Keywords: cellular mechanisms; molecular mechanisms; neuropsychiatric disorders; neurological disorders; neuroinflammation; neuronal signaling; gene expression; synaptic function; glial cells; peripheral factors
(This special issue belongs to the Section Cellular Pathology)
The Role of Mitochondria in Cell Development and Regeneration submission deadline 31 Dec 2025 | 1 articles | Viewed by 2844 | Submission Open
Keywords: mitochondria; fusion and fission; mtDNA; programmed cell death; cell development; mitochondria-ER contact; organelle
(This special issue belongs to the Section Mitochondria)
Genetic Mechanisms in Cellular Genomics and Therapeutics
edited by Elaine T. Lim and Yingleong Chan
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2700 | Submission Open
Keywords: genetics of human diseases; functional genomics; cellular mechanisms; genomics or stem cell technologies; therapeutics research and development for human diseases
The Role of Stem Cells and Circadian Clock in Cancer Immunotherapy
edited by Yool Lee
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2290 | Submission Open
Keywords: circadian clock; circadian disruption; neural stem cells; cancer stem cells; tumor– immune microenvironment; cancer chronotherapy
(This special issue belongs to the Section Stem Cells)
Standardization and Metrological Advancements in Cellular and Genomic Diagnostics for Cancer
edited by and Marika Fava
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1932 | Submission Open
Keywords: cancer diagnostics; cellular analysis; genomic profiling; precision medicine; metrology in diagnostics; next generation sequencing (NGS); reference measurement systems (RMSs); quality assurance (QA); IVDR compliance; SI-traceable standards
Integrated Approaches Between Metabolomics and Cellular Aging
edited by Maria Nikolaou and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1908 | Submission Open
Keywords: metabolomics; cellular aging; senescence; mitochondrial dysfunction; DNA damage; biomarkers; metabolism
(This special issue belongs to the Section Cellular Aging)
Novel Autoantibodies in Systemic Autoimmune Diseases: Challenges and Perspectives submission deadline 31 Dec 2025 | 1 articles | Viewed by 1853 | Submission Open
Keywords: autoantibodies; autoimmune diseases; innate and adaptive immunity
(This special issue belongs to the Section Cellular Immunology)
Cellular and Molecular Mechanisms of Heart Diseases
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1518 | Submission Open
Keywords: heart failure; HFrEF; HFpEF; molecular signaling; therapeutic interventions; ejection fraction; fibrosis; metabolism; mitochondrial dysfunction; cardiovascular therapies
(This special issue belongs to the Section Cellular Pathology)
The Role of T-Cells in Lymphomas and Leukemias
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1362 | Submission Open
Keywords: T cells; regulatory T cells; leukemia; lymphoma; hematological malignancies; chimeric antigen receptor; CAR T cells; tumor microenvironment; tumor-infiltrating T cells; TCR; adoptive T cell therapy; TCR-engineered T cells
(This special issue belongs to the Section Cellular Immunology)
The Role of T Cells and Cellular Signalling in Immune Diseases
edited by Daniela Gallo
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1210 | Submission Open
Keywords: T cells; autoimmune disorders; autoimmune endocrine disorders; targeted therapies
(This special issue belongs to the Section Cellular Immunology)
Colorectal Cancer: Molecular Mechanisms and Treatment Progress
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1069 | Submission Open
Keywords: colorectal cancer (CRC); tumor microenvironment; genetic and epigenetic alterations; immune evasion; targeted therapy and personalized medicine
(This special issue belongs to the Section Tissues and Organs)
Epigenetic Mechanisms and Aging
edited by
submission deadline 31 Dec 2025 | Viewed by 487 | Submission Open
Keywords: drosophila melanogaster; model organism; cell biology; developmental biology; genetics; molecular biology; cell signaling; cellular differentiation; cell proliferation; cell cycle; cellular morphogenesis; cell-cell communication; stem cells; cell migration; apoptosis; cytoskeleton; cell adhesion; cellular metabolism; functional genomics; CRISPR/Cas9 in drosophila; omics technologies; disease models; drug discovery; regeneration; genetic screens; cellular stress responses
(This special issue belongs to the Section Cellular Aging)
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