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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Macrophages in Cancer: Immunosuppression, Immunoregulation, and Immunotherapy

edited by

Abdullah Saeed

submission deadline 5 Jun 2026 | 4 articles | Viewed by 18681 | Submission Open

Keywords: macrophage; immunosuppression; immunoregulation; immunotherapy; tumor immune microenvironment

(This special issue belongs to the Section Cellular Immunology)

Novel Insights into Molecular Mechanisms and Therapy of Myeloma

edited by

Yusuke Furukawa

and

Jian Wu

submission deadline 10 Jun 2026 | 8 articles | Viewed by 28001 | Submission Open

Keywords: multiple myeloma; CAR-T therapy; relapse; methylation; drug resistance; treatment strategy; molecular mechanism; novel target; biomarker

(This special issue belongs to the Section Cellular Pathology)

Advances in Pulmonary Fibrosis

edited by Sergio Piñeiro Hermida

submission deadline 10 Jun 2026 | 3 articles | Viewed by 4353 | Submission Open

Keywords: pulmonary fibrosis; animal models; biomarkers; experimental therapeutics

(This special issue belongs to the Section Cellular Pathology)

Molecular Mechanisms of Cardiac Repair and Regeneration

edited by Mahesh Thirunavukkarasu

submission deadline 10 Jun 2026 | 1 articles | Viewed by 1451 | Submission Open

Keywords: cardiac repair and regeneration; cardiomyocyte; cardiac fibrosis; signaling pathways; immune regulation; extracellular vesicles; stem cell therapies; epigenetics; biomarkers

(This special issue belongs to the Section Cells of the Cardiovascular System)

The Metabolic Edge: How Cancer Cells Adapt, Survive, and Resist Therapy

edited by

Frank Schnütgen

submission deadline 10 Jun 2026 | 1 articles | Viewed by 653 | Submission Open

Keywords: cancer metabolism; metabolic rewiring; therapy resistance; metabolic plasticity; nutrient uptake; mitochondrial remodeling; tumor microenvironment; metabolic vulnerabilities

(This special issue belongs to the Section Cellular Metabolism)

Lipid Mediators in Cardiometabolic Regulation and Disease

edited by Adeniyi Michael Adebesin

submission deadline 10 Jun 2026 | Viewed by 197 | Submission Open

Keywords: lipid mediators; lipoprotein; fatty acid metabolites; cellular membranes; cardiometabolic regulation; cellular metabolism; adipogenesis; signaling pathways; receptors; lipid transport proteins

(This special issue belongs to the Section Cellular Metabolism)

The Role of Oxidative Stress in Cardiovascular Diseases—2nd Edition

edited by

Liya Yin

and

Chuanxi Cai

submission deadline 15 Jun 2026 | 4 articles | Viewed by 6792 | Submission Open

Keywords: oxidative stress; antioxidants; apoptosis; atherosclerosis; blood vessel; heart failure; hypertension; inflammation; mitochondria; microcirculation; reactive oxygen species

(This special issue belongs to the Section Cells of the Cardiovascular System)

Genomics and Cellular Mechanisms in Ovarian Cancer

edited by Hao Huang

submission deadline 15 Jun 2026 | 3 articles | Viewed by 3802 | Submission Open

Keywords: ovarian cancer; tumor heterogeneity; genomics and epigenomics; therapy resistance; tumor microenvironment

(This special issue belongs to the Section Tissues and Organs)

Cellular Origin of Glioma: From Triggers to Treatments

edited by

Katherine Karakoula

submission deadline 15 Jun 2026 | 2 articles | Viewed by 2453 | Submission Open

Keywords: glioblastoma; brain tumour; tumour heterogeneity; targeted therapy; glioma stem cells

Decoding Cellular Organization Through Spatial Omics

edited by Elizabeth Neumann

submission deadline 15 Jun 2026 | 1 articles | Viewed by 2028 | Submission Open

Keywords: spatial proteomics; lipomics; cellular architecture; biomolecular interactions; bioinformatics; integrative biology

Novel Insights into Developing Therapeutic Strategies for Neurological Disorders

edited by

Hui Jin Shin

, Joanna A. Korecka and

Yu-Han Huang

submission deadline 15 Jun 2026 | 1 articles | Viewed by 2011 | Submission Open

Keywords: neurological disorders; RNA therapeutics; gene therapy; antisense oligonucleotides; gene editing; cell therapy; precision medicine; neurodegenerative diseases; neurodevelopmental disorders; neurogenetic disorders

Cellular Metabolism and Immune Regulation in Cancer Progression and Metastasis

edited by Xu Jing

submission deadline 15 Jun 2026 | 1 articles | Viewed by 1538 | Submission Open

Keywords: cellular metabolism; tumor immunology; cancer progression; metastasis; immunometabolism; metabolic reprogramming; tumor microenvironment; immune evasion; cancer therapy; metabolic biomarkers

(This special issue belongs to the Section Cellular Metabolism)

Bone and Soft Tissue Tumors: Molecular Mechanisms and Emerging Therapeutics

edited by

Marcel Trautmann

submission deadline 15 Jun 2026 | 1 articles | Viewed by 679 | Submission Open

Keywords: sarcoma; bone and soft tissue tumors; molecular pathology; dysregulated signaling pathways; genetic and epigenetic alterations; therapeutic resistance; novel molecular biomarkers; therapeutic strategies; in vitro and in vivo models

Regulation of Hormone Secretion from Islets in Health and Disease

edited by

Md Shahidul Islam

submission deadline 15 Jun 2026 | Viewed by 367 | Submission Open

Keywords: islet hormone secretion; paracrine signaling; autocrine regulation; intra-islet communication; islet cell plasticity; transdifferentiation; multi-hormonal dysregulation; circadian regulation; single-cell omics; islet inflammation and immune crosstalk

Overcoming Resistance to Immune Checkpoint Inhibitors in Cancer: Mechanisms, Models, and Therapeutic Strategies

edited by Nai-Yun Sun,

Yoshimasa Tanaka

and

Hsin-Fang Tu

submission deadline 15 Jun 2026 | Viewed by 243 | Submission Open

Keywords: immune checkpoint inhibitors; primary resistance; acquired resistance; tumor microenvironment; immune exhaustion; preclinical cancer models; genetic and epigenetic alterations; excluded/desert tumors; inflamed tumors; cancer immunotherapy

Decoding the Complexity of Angiogenesis: Insights into Vascular Formation and Disease

edited by

Kay-Dietrich Wagner

submission deadline 20 Jun 2026 | 4 articles | Viewed by 6868 | Submission Open

Keywords: angiogenesis; vasculogenesis; development; physiological angiogenesis; pathophysiology; cell– cell communication; cell signaling

(This special issue belongs to the Section Cells of the Cardiovascular System)

Molecular Mechanism of Liver Transplantation

edited by Carmen Peralta and Juan Carlos Cutrin

submission deadline 20 Jun 2026 | 1 articles | Viewed by 5116 | Submission Open

Keywords: liver transplantation; ischemia-reperfusion injury; signaling pathways; graft dysfunction; sterile inflammation; liver regeneration; fatty grafts; normothermic machine perfusion; defatting strategies

(This special issue belongs to the Section Tissues and Organs)

Mechanisms of Antimicrobial Treatment in Human Diseases

edited by

Paolo Gaibani

submission deadline 20 Jun 2026 | 1 articles | Viewed by 3672 | Submission Open

Keywords: multidrug resistance; epidemiology; novel antimicrobial resistance traits

(This special issue belongs to the Section Cellular Pathology)

Progress of Nanoparticles in the Treatment of Cancers

edited by

Mohammad Asif Sherwani

, Nafees Ahamad and

Robin Kumar

submission deadline 20 Jun 2026 | 2 articles | Viewed by 3657 | Submission Open

Keywords: nanoparticles; cancer treatment; cellular mechanisms; molecular biology; pathophysiology; drug delivery; drug resistance; immunotherapy; tumor microenvironment

(This special issue belongs to the Section Cell Microenvironment)

Beyond Bystanders: The Emerging Roles of Glia in Brain Health and Disease

edited by

Ruqayya Afridi

submission deadline 20 Jun 2026 | 3 articles | Viewed by 3461 | Submission Open

Keywords: astrocytes; microglia; oligodendrocytes; neuroinflammation; neuroimmunology; synaptic plasticity; blood– brain barrier; neuropsychiatric disorders

(This special issue belongs to the Section Cellular Neuroscience)

Biomolecular Condensates in Oncology and Immunology

edited by

Andrzej Mackiewicz

Pravin B. Sehgal

and

Mariusz Kaczmarek

submission deadline 20 Jun 2026 | 1 articles | Viewed by 2330 | Submission Open

Keywords: liquid-liquid phase separation (LLPS); biomolecular condensates; pro-oncogenic signaling; innate and adaptive immunity; transcriptional regulation; epigenetic regulation; condensate targeting; antiviral mechanisms; intercellular adhesion; cell migration and metastasis

(This special issue belongs to the Section Cellular Immunology)

Molecular Anatomy and Function of Sensory Organs and Sensory Tissues

edited by

Frank Schmitz

submission deadline 20 Jun 2026 | 2 articles | Viewed by 2008 | Submission Open

Keywords: sensory organ; sensory tissue; vision; hearing; skin; sensory structures of internal organs

(This special issue belongs to the Section Tissues and Organs)

Molecular and Cellular Mechanisms of Insulin Secretion

edited by

Haiqiang Dou

submission deadline 20 Jun 2026 | Viewed by 1924 | Submission Open

Keywords: insulin secretion; beta-cells; pancreatic islets; diabetes; exocytosis; Ca2+

(This special issue belongs to the Section Cellular Metabolism)

New Insights into Astrocytes in Health and Disease

edited by

Tao Tao

submission deadline 20 Jun 2026 | 2 articles | Viewed by 1187 | Submission Open

Keywords: astrocytes heterogeneity; blood-brain barrier (BBB); synaptic modulation; metabolic support; neuroinflammation; ageing; neurodegenerative disorders; neurodevelopmental disorders; stress response

(This special issue belongs to the Section Cellular Neuroscience)

Research on Islet Cell Biology

edited by Mazhar Kanak

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1062 | Submission Open

Keywords: islet inflammation; hypoxia in islets; functional assessment of islets ex vivo and in vivo; islet stress and EVs as markers of stress; encapsulation strategies for islet transplantation; hot topics in islet and SC-beta cell transplantation

Metabolic Reprogramming in Organ Fibrosis and Regeneration

edited by

Melanie Tran

and Dong Yang

submission deadline 20 Jun 2026 | 1 articles | Viewed by 595 | Submission Open

Keywords: metabolic reprogramming; fibrosis; tissue regeneration; cellular metabolism; mitochondrial dysfunction; tissue repair and remodeling

(This special issue belongs to the Section Cellular Metabolism)

Cutaneous Regeneration and Tissue Engineering: From Hair Follicle Regeneration to Skin Restoration

edited by Soung-Hoon Lee

submission deadline 25 Jun 2026 | 4 articles | Viewed by 3382 | Submission Open

Keywords: skin regeneration; hair follicle regeneration; tissue engineering; regenerative biology; biomaterial scaffolds; organoids and 3D skin models; wound healing; acellular matrices; exosome-based therapy; translational dermatology

The Orchestration of Glial Cells in Health and Disease

edited by Keying Zhu

submission deadline 25 Jun 2026 | 1 articles | Viewed by 2211 | Submission Open

Keywords: microglia; oligodendrocytes; astrocytes; myelin; neuroinflammation

The Function of Stem Cells in the Biomedical Applications

edited by Rakesh Kumar Srivastava

submission deadline 25 Jun 2026 | 1 articles | Viewed by 1254 | Submission Open

Keywords: stem cells; regenerative medicine; cell therapy; differentiation; disease modeling; tissue engineering; drug discovery

Extracellular Vesicles Based Drug Delivery

edited by

Giovanni Camussi

and

Cristina Grange

submission deadline 25 Jun 2026 | Viewed by 601 | Submission Open

Keywords: EV engineering; targeting; therapy; natural carrier; exosomes

Regenerating Poorly Vascularized Tissues

edited by Simone Pacini

submission deadline 25 Jun 2026 | Viewed by 382 | Submission Open

Keywords: regenerative medicine; avascular tissue; angiogenesis; vasculogenesis; cell-based medicinal products; bioengineered materials; cell transplantation

(This special issue belongs to the Section Tissues and Organs)

Novel Insights in Chronic Epilepsy—from Molecular Mechanisms to Future Therapies

edited by Kjell Heuser and

Cecilie Nome

submission deadline 25 Jun 2026 | Viewed by 238 | Submission Open

Keywords: epilepsy; epileptogenesis; seizure mechanisms; neuroinflammation; glial cells; reactive gliosis; astrocytes; microglia; antiseizure medication

Systemic Sclerosis: Cellular Mechanisms, Innovative Diagnostics and Advanced Therapeutics

edited by Muhammad Soyfoo

submission deadline 25 Jun 2026 | Viewed by 212 | Submission Open

Keywords: systemic sclerosis; fibrosis; myofibroblasts; immune dysregulation; endothelial dysfunction; extracellular matrix (ECM); autoimmune disease

Inflammation and Atherosclerosis: Emerging Mechanisms, Biomarkers and Therapeutic Opportunities

edited by Victoria McGilligan

submission deadline 25 Jun 2026 | Viewed by 194 | Submission Open

Keywords: atherosclerosis; inflammation; inflammatory biomarkers; anti-inflammatory therapies; plaque vulnerability; diagnostics and prognostics

Diabetes-Induced Organ Damage: Cellular Mechanisms and Therapeutic Opportunities

edited by

Mohammed S. Razzaque

submission deadline 30 Jun 2026 | 9 articles | Viewed by 55253 | Submission Open

Keywords: diabetes mellitus; vascular lesions; nephropathy; cardiomyopathy; neuropathy; retinopathy; therapeutic opportunities

(This special issue belongs to the Section Tissues and Organs)

Exclusive Review Papers in Parkinson's Research

edited by

Wolfgang Jost

and Ronald F. Pfeiffer

submission deadline 30 Jun 2026 | 3 articles | Viewed by 19724 | Submission Open

Keywords: Parkinson’ s disease; alpha-synuclein; substantia nigra; mitochondria; non-motor symptoms; dopamine; levodopa

(This special issue belongs to the Section Cellular Aging)

New Research on Immunity and Inflammation in Cardiovascular Disease

edited by Pavel Poredoš

submission deadline 30 Jun 2026 | 7 articles | Viewed by 19352 | Submission Open

Keywords: inflammation; atherosclerosis; coronary artery disease; peripheral arterial disease; cerebrovascular disease; venous thromboembolic disease; circulating biomarkers; anti-innflammatory treatment of cardiovascular disease

(This special issue belongs to the Section Cells of the Cardiovascular System)

Role of Calpains in Health and Diseases

edited by

Michel Baudry

and Peter A. Greer

submission deadline 30 Jun 2026 | 7 articles | Viewed by 14446 | Submission Open

Keywords: calpain; physiology; biochemistry; disease; mutation; target; inhibitor

(This special issue belongs to the Section Cellular Pathology)

Emerging Topics in Smooth Muscle Cell Fate and Plasticity in Atherosclerosis

edited by

Mandy Grootaert

and

Julián Albarrán-Juárez

submission deadline 30 Jun 2026 | 6 articles | Viewed by 13184 | Submission Open

Keywords: vascular smooth muscle cells; lineage tracing; fate mapping; VSMC plasticity; (single cell) (spatial) omics; vascular heterogeneity; atherosclerosis

(This special issue belongs to the Section Cellular Pathology)

Cell Migration and Invasion

edited by Veronika Miskolci

submission deadline 30 Jun 2026 | 7 articles | Viewed by 12287 | Submission Open

Keywords: cell migration; cell invasion; cancer metastasis; molecular mechanisms; therapeutic strategies; signaling pathways

Myocardial Ischemia/Reperfusion Injury: Mechanisms and New Directions in Cardioprotection

edited by Sauri Hernandez-Resendiz

submission deadline 30 Jun 2026 | 3 articles | Viewed by 10330 | Submission Open

Keywords: myocardial infarction; heart failure; ischemia/reperfusion injury; no-reflow phenomenon; oxidative stress; cell death; cardiac metabolism; mitochondrial quality control; inflammation; cardioprotection

(This special issue belongs to the Section Tissues and Organs)

Pathology and Treatments of Amyotrophic Lateral Sclerosis (ALS)

edited by Laxman Gangwani

submission deadline 30 Jun 2026 | 2 articles | Viewed by 8859 | Submission Open

Keywords: amyotrophic lateral sclerosis (ALS); pathology; molecular mechanisms; treatments; symptom management; biological mechanisms; risk factors; innovative treatments

(This special issue belongs to the Section Cellular Pathology)

Novel Insights into Mechanism and Treatment of Degenerative Disc Disease

edited by Yejia Zhang

submission deadline 30 Jun 2026 | 5 articles | Viewed by 7558 | Submission Open

Keywords: intervertebral disc (IVD) degeneration; back pain; age; genetics; injury

(This special issue belongs to the Section Cellular Pathology)

Study on Immune Activity of Natural Products

edited by Xiu-Min Li

submission deadline 30 Jun 2026 | 4 articles | Viewed by 5328 | Submission Open

Keywords: natural products; bioactive compounds; immune activity; immunomodulation; inflammation; autoimmune diseases; immunotherapy; therapeutic potential

AMPK: From Mechanisms to New Therapies

edited by

Roland Abi Nahed

and

Farah Diab

submission deadline 30 Jun 2026 | 3 articles | Viewed by 5323 | Submission Open

Keywords: metabolism; AMPK; cancer; biosensors; reproduction; metabolic disorders; therapies

Multifaceted Nature of Immune Responses to Viral Infection

edited by Homayon Ghiasi and Susmit Suvas

submission deadline 30 Jun 2026 | 5 articles | Viewed by 4792 | Submission Open

Keywords: viral infection; innate and adaptive immunity; protection; RNA and DNA viruses; autoimmunity; immune escape

MicroRNAs: Regulators of Cellular Fate

edited by

Hsiuying Wang

submission deadline 30 Jun 2026 | 3 articles | Viewed by 3782 | Submission Open

Keywords: microRNA targets; microRNA conservation; microRNA pathway; microRNA mimics; microRNA antagonist; disease biomarker

Protein and RNA Regulation in Cells

edited by

Delai Huang

and

Denis Mottet

submission deadline 30 Jun 2026 | 2 articles | Viewed by 3494 | Submission Open

Keywords: gene expression; post-transcriptional regulation; post-translational modifications; non-coding RNAs; regulatory networks; protein degradation; RNA decay

Emerging Topics in Cachexia

edited by Gabriela Salim Ferreira De Castro

submission deadline 30 Jun 2026 | 2 articles | Viewed by 2871 | Submission Open

Keywords: cachexia; skeletal muscle loss; adipose tissue loss; inflammation; sarcopenia; cancer; body composition; biomarkers

Understanding Nasal Inflammation: The Interplay of Diagnosis, Endotypes, and Environmental Shifts

edited by Simonetta Masieri and

Carlo Cavaliere

submission deadline 30 Jun 2026 | 1 articles | Viewed by 2532 | Submission Open

Keywords: rhinology; allergy; immunology; environment; pollution; microbiome; inflammation; united airway disease; lymphocyte cells; interleukins

(This special issue belongs to the Section Tissues and Organs)

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