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Oral, Volume 6, Issue 1

2026 February - 25 articles

Cover Story: Generative artificial intelligence (AI) is increasingly explored as a supportive tool in healthcare. This retrospective study evaluates the role of generative AI, specifically Microsoft CoPilot, as an adjunctive decision-support tool in oral and maxillofacial radiology. It assesses the effectiveness of CoPilot in providing meaningful differential diagnosis and management strategies compared to reports generated by a board-certified oral and maxillofacial radiologist. The study highlights the strengths and limitations of integrating such tools, while emphasizing the experience and expertise of a radiologist. The results indicate generative AI is not yet suitable for extensive clinical applications and requires refinement before it can consistently provide reliable and relevant information to support clinicians. View this paper
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Articles (25)

  • Article
  • Open Access
1,161 Views
24 Pages

15 February 2026

Objectives: The present study evaluated the efficacy of a preparation based on bacterial lysates of Streptococcus oralis, Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum in the treatment of experimental periodontitis in rats, compar...

  • Article
  • Open Access
1,302 Views
13 Pages

Expression of miR141-3p, 146a-5p, and 148-3p in Periodontal Disease

  • Eliakym Arámbula Meraz,
  • Andrea Ross Orozco,
  • Maricela Ramírez Álvarez,
  • Noemi García Magallanes and ,
  • América Yazmín Torres Moreno,
  • Gloria Elena Guzmán Celaya,
  • Valeria Ibarra Villanueva,
  • Jesús Armando Beltrán León,
  • Adriana Koratzy Ochoa García and
  • Fred Luque Ortega
  • + 5 authors+ 0 author

14 February 2026

Background: Periodontal disease is a chronic inflammatory condition characterized by progressive destruction of the supporting tissues of the teeth. MicroRNAs (miRNAs) have emerged as key post-transcriptional regulators of immune and inflammatory res...

  • Review
  • Open Access
2,269 Views
11 Pages

Ferroptosis and Periodontal Tissue Destruction: What We Currently Know

  • Leopoldo Mauriello,
  • Giuseppe Trapanese,
  • Vitolante Pezzella,
  • Graziano Zappalà and ,
  • Elio Ramaglia,
  • Vincenzo Iorio-Siciliano,
  • Luca Ramaglia and
  • Andrea Blasi
  • + 3 authors+ 0 author

11 February 2026

Background: Periodontitis is a disease characterized by the destruction of periodontal tissue and tooth loss. The molecular mechanisms behind this disease, however, are not clearly understood. Ferroptosis is an iron-dependent, lipid peroxidation-driv...

  • Case Report
  • Open Access
1,352 Views
7 Pages

10 February 2026

Objective: Bilateral cleft lip and palate (BCLP) is a craniofacial malformation often associated with anatomical and functional impairments, including a shallow oral vestibule in the premaxillary region. This condition requires a vestibuloplasty to r...

  • Article
  • Open Access
776 Views
9 Pages

10 February 2026

Objective: This study was intended to evaluate the effects of the case-based learning (CBL) and Sandwich teaching methods in clinical practice of prosthodontics. Methods: 82 fifth-year students who were undertaking clinical practice of prosthodontics...

  • Review
  • Open Access
1,546 Views
11 Pages

Infective Endocarditis, Antibiotic Resistance and Dentistry: Clinical and Medico-Legal Aspects

  • Fabio Massimo Sciarra,
  • Giovanni Caivano,
  • Emanuele Di Vita,
  • Mario Palermiti and ,
  • Pietro Messina,
  • Enzo Maria Cumbo,
  • Luigi Caradonna,
  • Salvatore Nigliaccio,
  • Davide Alessio Fontana and
  • Giuseppe Alessandro Scardina
  • + 6 authors+ 1 author

6 February 2026

Background: Infective endocarditis (IE) is a severe and multifactorial condition historically linked to dental procedures. Current evidence shows that most cases arise from complex host–microbe interactions and biofilm colonization on damaged e...

  • Article
  • Open Access
2,541 Views
13 Pages

Two-Year Evaluation of a CAMBRA-Based Caries Prevention Program in Preschool Children: Risk Reduction and Clinical Outcomes

  • Luigi Sardellitti,
  • Francesca Luisa Floris,
  • Marco Bonardi,
  • Giovanni Landi and ,
  • Anna Di Marzio,
  • Matteo Caviglia,
  • Chiara Ciacciarelli,
  • Elisa Deidda,
  • Enrica Filigheddu and
  • Egle Patrizia Milia
  • + 5 authors+ 0 author

5 February 2026

Background/Objectives: Dental caries remains one of the most prevalent chronic diseases in early childhood, and traditional preventive strategies often fail to achieve sustained risk reduction without individualized management. The Caries Management...

  • Article
  • Open Access
1,264 Views
15 Pages

4 February 2026

Studies on links between Oral Health-Related Quality of Life (OHRQoL) and use of dental services among UK children are lacking. This study aimed to assess the relationship between OHRQoL and dental attendance in 12- and 15-year-old children in the UK...

  • Case Report
  • Open Access
2 Citations
1,557 Views
8 Pages

Serratia marcescens Maxillary Sinusitis and Ethmoiditis in an HIV-Positive Patient Caused by Dental Implant Migrating into the Maxillary Sinus

  • Tomasz Marecik,
  • Krzysztof Gąsiorowski,
  • Jakub Bargiel,
  • Grażyna Wyszyńska-Pawelec and
  • Michał Gontarz

3 February 2026

Iatrogenic maxillary sinusitis accounts for a significant proportion of unilateral sinus infections. This report describes a 36-year-old HIV-positive patient with Serratia marcescens chronic left maxillary sinusitis and ethmoiditis caused by migratio...

  • Systematic Review
  • Open Access
3 Citations
3,286 Views
29 Pages

Head-to-Head: AI and Human Workflows for Single-Unit Crown Design—Systematic Review

  • Andrei Vorovenci,
  • Viorel Ștefan Perieanu,
  • Mihai Burlibașa,
  • Mihaela Romanița Gligor and ,
  • Mădălina Adriana Malița,
  • Mihai David,
  • Camelia Ionescu,
  • Ruxandra Stănescu,
  • Mona Ionaș and
  • Andi Ciprian Drăguș
  • + 9 authors+ 4 authors

2 February 2026

Objectives: To compare artificial intelligence (AI) crown design with expert or non-AI computer-aided (CAD) design for single-unit tooth and implant-supported crowns across efficiency, marginal and internal fit, morphology and occlusion, and mechanic...

  • Article
  • Open Access
2,058 Views
11 Pages

2 February 2026

Background: The progressive aging of the population has led to an increased prevalence of chronic diseases and polypharmacy, with arterial hypertension representing one of the most frequent conditions. Consequently, the management of vital signs duri...

  • Case Report
  • Open Access
1 Citations
2,491 Views
15 Pages

Injection Molding and Palatal Silicone Key Combination: A Hybrid Approach for Complex Anterior Cases

  • Maria Fostiropoulou,
  • Eftychia Pappa,
  • Konstantinos Tzimas and
  • Efstratios Papazoglou

26 January 2026

Background/Objectives: This article presents a novel approach that combines the Palatal Silicone Key and Injection Molding techniques as a viable alternative for complex anterior cases with high esthetic demands, where layering multiple shades is ess...

(This article belongs to the Special Issue Artificial Intelligence in Oral Medicine: Advancements and Challenges)
  • Article
  • Open Access
1,599 Views
28 Pages

The Effect of Saliva on the Adhesion of Candida albicans to Prosthodontic Obturator Materials

  • Karl M. Lyons,
  • Robert M. Love,
  • John Beumer,
  • Mahmoud M. Bakr and
  • Richard D. Cannon

14 January 2026

Objectives: This study aimed to investigate the influence of saliva on the adhesion of C. albicans to various obturator prosthetic materials. Methods: This in vitro study investigated C. albicans adherence using clinical isolates, including one isola...

  • Article
  • Open Access
2,382 Views
21 Pages

Dental Preparation Guides—From CAD to PRINT and CAM

  • Florina Titihazan,
  • Tareq Hajaj,
  • Andreea Codruța Novac,
  • Daniela Maria Pop and ,
  • Cosmin Sinescu,
  • Meda Lavinia Negruțiu,
  • Mihai Romînu and
  • Cristian Zaharia
  • + 3 authors+ 0 author

12 January 2026

Objectives: The aim of this study was to present and describe a digital workflow integrating Digital Smile Design (DSD) with computer-aided design/computer-aided manufacturing (CAD/CAM) and additive manufacturing technologies for the fabrication of d...

  • Article
  • Open Access
1,593 Views
18 Pages

12 January 2026

Objectives: This cross-sectional study aimed to evaluate oral health knowledge, self-perceived oral status, hygiene behaviors, prevalence of dental injuries, and mouthguard use among Croatian basketball players and coaches. Materials and Methods: A t...

(This article belongs to the Special Issue Oral Health in Athletes: Risks, Prevention, Management, and Education)
  • Article
  • Open Access
1,747 Views
14 Pages

9 January 2026

Objectives: To assess the utility of Microsoft Copilot, a generative AI tool, in providing meaningful differential diagnosis and management strategies comparable with those generated by a board-certified radiologist using cone beam computed tomograph...

  • Article
  • Open Access
3 Citations
1,791 Views
17 Pages

The Effect of RAMPA Therapy on the Volumetric Evaluation of the Nasal Cavity and Sinus: A Comparative Statistical Analysis in Patients with Clear Versus Opacified Paranasal Sinuses

  • Yasushi Mitani,
  • Yuko Okai-Kojima,
  • Mohammad Moshfeghi,
  • Morio Tonogi and ,
  • Shouhei Ogisawa and
  • Bumkyoo Choi
  • + 1 author+ 0 author

8 January 2026

Objectives: This study aimed to comprehensively evaluate and compare the therapeutic effects of Right Angle Maxillary Protraction Appliance (RAMPA) therapy on nasal airway volume in pediatric patients, specifically differentiated by their baseline ra...

  • Article
  • Open Access
1,504 Views
11 Pages

Oral Health, Periodontal Status, and Cognitive Function in Middle-Aged and Older Adults: A Cross-Sectional Analytical Pilot Study

  • Norma Cruz-Fierro,
  • Myriam Angélica de la Garza-Ramos,
  • Sara Sáenz-Rangel,
  • María Concepción Treviño Tijerina and ,
  • Guillermo Cano-Verdugo and
  • Víctor Hugo Urrutia Baca
  • + 1 author+ 0 author

8 January 2026

Background: Cognitive aging is a physiological process that involves gradual and mild changes in mental functions. When these changes significantly affect cognitive performance, it is considered cognitive decline. Objective: This analytical cross-sec...

  • Article
  • Open Access
1 Citations
1,892 Views
12 Pages

Palatal Vault Depth Affects the Accuracy of the Intaglio Surface of Complete Maxillary Denture Bases Manufactured Through Additive Manufacturing

  • Ben J. Smith,
  • Louis George,
  • Duman Davari,
  • Jeremy Collins and ,
  • Jordan Orth,
  • Mahmoud M. Bakr,
  • Santosh Kumar Tadakamadla and
  • Andrew B. Cameron
  • + 3 authors+ 0 author

6 January 2026

Background/Objectives: The purpose of this in vitro study is to evaluate the effect varying palatal vault depths have on the accuracy of complete maxillary denture bases fabricated using additive manufacturing technology. Methods: One hundred complet...

(This article belongs to the Collection Digital Dentistry: State of the Art and Future Perspectives)
  • Article
  • Open Access
1,488 Views
10 Pages

6 January 2026

Objective: This is the first population-based study to separately examine whether preventive and treatment dental visits modify the association between stressful life events and toothache. Psychological stress may alter health-seeking behaviors and p...

(This article belongs to the Topic Advances in Dental Health, 2nd Edition)
  • Article
  • Open Access
1 Citations
1,793 Views
11 Pages

Mastication and Swallowing Times Associated with Eating Satisfaction Among Community-Dwelling Older People

  • Ichizo Morita,
  • Koji Hara,
  • Kanae Kondo,
  • Yusuke Matsumoto and ,
  • Iwane Sugiura,
  • Yujo Inagawa,
  • Seiji Nakashima,
  • Taketsugu Nomura,
  • Yoshikazu Abe and
  • Satomi Maruyama
  • + 6 authors+ 1 author

6 January 2026

Background: The time from mastication to swallowing is used as an indicator of masticatory and swallowing functions. However, there have been no reports on reasonable eating times associated with eating satisfaction. Clarifying the reasonable time fo...

  • Article
  • Open Access
1 Citations
1,576 Views
13 Pages

Salivary Nickel and Chromium Levels in Orthodontic Patients with and Without Fixed Metallic Appliances

  • Youssouf Ouédraogo,
  • Abdoul Karim Sakira,
  • Soumaïla Kindo,
  • Abdoul Azize Zallé and ,
  • Moussa Ouédraogo,
  • Ahia Monique Lydie Beugré-Kouassi and
  • Jean Bertin Beugré
  • + 2 authors+ 0 author

5 January 2026

Background/Objectives: Dental malocclusions are often treated with appliances made of metal alloys. These alloys biodegrade in oral cavity and release toxic metals such as nickel and chromium. This study aimed to assess nickel and chromium content in...

  • Article
  • Open Access
2,664 Views
22 Pages

Management of Patients with Medication-Related Osteonecrosis of the Jaw: A 15-Year Cohort Study from a Tertiary Centre

  • George N. Romanos,
  • Dimitrios Deligiannidis,
  • Dimosthenis Igoumenakis,
  • Eleni Konsolaki and ,
  • Chrysostomos Zioudas,
  • Georgios Karakinaris,
  • Athanassios Kyrgidis and
  • Sofia Aggelaki
  • + 3 authors+ 0 author

4 January 2026

Background/Objectives: Medication-related osteonecrosis of the jaw (MRONJ) is a serious complication of antiresorptive and antiangiogenic drugs with no consensus on optimal treatment. This study aimed to evaluate the clinical outcomes of MRONJ patien...

  • Article
  • Open Access
1,711 Views
10 Pages

YouTube as an Educational Source for Pediatric Orthodontic Treatments: A Comparative Study of Clear Aligners, Fixed Braces, and Lingual Braces

  • Sezai Erginbas,
  • Andrea Boggio,
  • Nur Ozel Erginbas,
  • Sara Iadecola and ,
  • Giorgio Gastaldi and
  • Mauro Cozzani
  • + 1 author+ 0 author

24 December 2025

Introduction: This study aimed to evaluate the educational value of YouTube videos presenting information on pediatric orthodontic treatments, specifically clear aligners, fixed braces, and lingual braces. Methods: A cross-sectional analysis was cond...

  • Article
  • Open Access
1 Citations
1,852 Views
12 Pages

Two-Year Outcomes of Tissue-Level and Bone-Level Two-Piece Zirconia Implants: A Case Series

  • Sonja Žarković Gjurin,
  • Katja Povšič,
  • Tom Kobe,
  • Borut Žužek and ,
  • Rok Gašperšič and
  • Čedomir Oblak
  • + 1 author+ 0 author

19 December 2025

Background/objectives: Zirconia dental implants are increasingly recognised as an alternative to titanium implants due to their biocompatibility and aesthetics. Initially developed as one-piece systems, zirconia implants have evolved into two-piece d...

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Oral - ISSN 2673-6373