2026 December - 13 articles
Which patients benefit from carfilzomib in multiple myeloma depends on the regimen, the comparator and the treatment phase. This critical narrative review integrates randomised trials, selected translational and observational studies, guidance, and t...
Background: Relapsed or refractory acute myeloid leukemia (R/R AML) poses significant therapeutic challenges due to its aggressive nature. With numerous salvage therapies available, clinicians often face uncertainty regarding optimal treatment select...
Background/Objectives: Autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP) are uncommon hematologic immune-related adverse events of immune checkpoint inhibitors (ICIs). We evaluated whether strict reporting signals were consistent a...
Background/Objectives: Corticosteroids are the standard first-line treatment for immune thrombocytopenia (ITP), a disorder that itself carries an excess risk of thrombosis, yet the evidence on corticosteroid-associated thrombotic risk in ITP has not...
Precision medicine is entering a phase in which the principal question is no longer whether new technologies can generate biologically meaningful information, but how that information can be validated, regulated, scaled and integrated into clinical d...
Classic Hodgkin lymphoma (cHL) is histologically defined by rare Hodgkin and Reed–Sternberg (HRS) cells embedded within an extensive, biologically active immune microenvironment that HRS cells actively recruit and reprogram to sustain their own...
Background/Objectives: This study describes demographic and clinical characteristics and treatment patterns (including sequencing) in patients with chronic lymphocytic leukemia (CLL) in Spain. Methods: A retrospective, multicenter, cross-sectional st...
Background: Congenital thrombotic thrombocytopenic purpura (cTTP) is an extremely rare disease caused by an inherited deficiency of ADAMTS13. Residual ADAMTS13 activity <3% is associated with earlier disease onset and the need for prophylactic tre...
Background/Objectives: Hematopoietic stem cell transplantation (HSCT) is a life-saving treatment for many hematological disorders, but demand for unrelated donors continues to outpace donor-registry growth. Voluntary blood donors are a strategic popu...
Background/Objectives: Primary plasma cell leukemia (pPCL) is a rare and highly aggressive plasma cell malignancy with poor prognosis and limited therapeutic options. This study aimed to characterize global publication and citation trends, leading co...
The history of chronic myeloid leukemia (CML) is one of the clearest demonstrations of how biological insight, therapeutic innovation, and disciplined clinical observation can transform the natural history of a malignant disease [...]
Idiosyncratic drug-induced severe neutropenia and agranulocytosis are rare but potentially life-threatening adverse drug reactions. They cause profound neutrophil depletion after exposure to non-cytotoxic medications. Advances in supportive care have...
Prolidase deficiency is an ultra-rare autosomal recessive metabolic disorder caused by pathogenic variants in the PEPD gene, resulting in impaired turnover of proline-rich proteins, including collagen. It is characterized by chronic skin lesions, rec...
