Bioengineering, Volume 10, Issue 12
2023 December - 104 articles
Cover Story: Obstruction of the LVAD flow path can occur when blood clots or tissue overgrowth form within the inflow cannula, pump body, or outflow graft, and it can lead to thrombus, embolism, and stroke. The impact of progressive pump inflow obstruction (PO) on the pressure and flow dynamics of the LVAD-supported heart was measured in a mock circulatory loop. Pressure and flow decreased with PO, shifting more of the flow through the aortic valve such that the total flow decreased by 6–11% and decreased the efficiency of the work of the native heart up to 60%. PO restricts diastolic flow through the LVAD, which reduces mitral inflow and decreases the strength and energy of the intraventricular vortices. The changes in flow architecture produced by PO include flow stasis and increased shear, which predispose the system to thromboembolic risk. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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