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Toxics, Volume 9, Issue 10

2021 October - 41 articles

Cover Story: One factor contributing to the prevalence of e-cigarette usage in the United States is the availability of multiple flavors. Studies in the past have shown that reactive oxidative species (ROS) content within the aerosols generated by e-cigarettes varyies among different flavors. Exposure to exogenous ROS via e-cigarette aerosols can induce damage in pulmonary cells. Through conducting comparative analyses of ROS from aerosols generated from vape bars of different flavors and nicotine concentrations, we believe the results of our study will better elucidate how flavoring agents used in vape bars of various different nicotine concentrations induce differential oxidative- stress-mediated toxicological effects. View this paper
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Articles (41)

  • Review
  • Open Access
76 Citations
7,198 Views
21 Pages

The Effects of Essential and Non-Essential Metal Toxicity in the Drosophila melanogaster Insect Model: A Review

  • Mitchell R. Slobodian,
  • Jesse D. Petahtegoose,
  • Athena L. Wallis,
  • Danica C. Levesque and
  • Thomas J. S. Merritt

16 October 2021

The biological effects of environmental metal contamination are important issues in an industrialized, resource-dependent world. Different metals have different roles in biology and can be classified as essential if they are required by a living orga...

  • Feature Paper
  • Article
  • Open Access
23 Citations
3,768 Views
9 Pages

Biochar Amendment Reduces the Availability of Pb in the Soil and Its Uptake in Lettuce

  • Andrea Vannini,
  • Elisabetta Bianchi,
  • Diego Avi,
  • Nicole Damaggio,
  • Luigi Antonello Di Lella,
  • Francesco Nannoni,
  • Giuseppe Protano and
  • Stefano Loppi

15 October 2021

The aim of this study was to investigate the ability of biochar amendment to reduce the availability of Pb in the soil and its uptake in lettuce (Lactuca sativa L. var. adela). Seedlings of lettuce were cultivated in Pb-contaminated soils, both with...

  • Article
  • Open Access
3 Citations
2,268 Views
7 Pages

14 October 2021

Interspecies correlation estimation (ICE) models are linear regressions that predict toxicity to a species with few data using a known toxicity value in a surrogate species. ICE models are well established for estimating toxicity to fish and aquatic...

  • Article
  • Open Access
8 Citations
3,266 Views
14 Pages

Removal of Antimony(V) from Drinking Water Using nZVI/AC: Optimization of Batch and Fix Bed Conditions

  • Huijie Zhu,
  • Qiang Huang,
  • Shuai Fu,
  • Xiuji Zhang,
  • Zhe Yang,
  • Jianhong Lu,
  • Bo Liu,
  • Mingyan Shi,
  • Junjie Zhang and
  • Junlong Li
  • + 1 author

14 October 2021

Antimony (Sb) traces in water pose a serious threat to human health due to their negative effects. In this work, nanoscale zero-valent iron (Fe0) supported on activated carbon (nZVI) was employed for eliminating Sb(V) from the drinking water. To bett...

  • Feature Paper
  • Article
  • Open Access
18 Citations
4,603 Views
19 Pages

Epidemiology of Animal Poisonings in the Canary Islands (Spain) during the Period 2014–2021

  • Cristian Rial-Berriel,
  • Andrea Acosta-Dacal,
  • Manuel Zumbado,
  • Luis Alberto Henríquez-Hernández,
  • Ángel Rodríguez-Hernández,
  • Ana Macías-Montes,
  • Luis D. Boada,
  • María del Mar Travieso-Aja,
  • Beatriz Martin-Cruz and
  • Octavio P. Luzardo
  • + 2 authors

14 October 2021

Animal poisoning is one of the greatest conservation threats facing wildlife. In a preliminary study in the oceanic archipelago of the Canary Islands, we showed that the degree of threat from this circumstance was very high-even higher than that repo...

  • Article
  • Open Access
19 Citations
5,736 Views
12 Pages

Influence of Electronic Cigarettes on Antioxidant Capacity and Nucleotide Metabolites in Saliva

  • Dominika Cichońska,
  • Oliwia Król,
  • Ewa M. Słomińska,
  • Barbara Kochańska,
  • Dariusz Świetlik,
  • Jolanta Ochocińska and
  • Aida Kusiak

14 October 2021

The balance between reactive oxygen species production and the activity of antioxidant systems present in saliva is an important element in maintaining oral environment homeostasis. E-cigarettes adversely affect the oral cavity and their cytotoxic ef...

  • Article
  • Open Access
41 Citations
3,965 Views
18 Pages

14 October 2021

Traffic is a significant pollution source in cities and has caused various health and environmental concerns worldwide. Therefore, an improved understanding of traffic impacts on particle concentrations and their components could help mitigate air po...

  • Article
  • Open Access
6 Citations
3,040 Views
15 Pages

Environmental Risk Assessment of Vehicle Exhaust Particles on Aquatic Organisms of Different Trophic Levels

  • Konstantin Pikula,
  • Mariya Tretyakova,
  • Alexander Zakharenko,
  • Seyed Ali Johari,
  • Sergey Ugay,
  • Valery Chernyshev,
  • Vladimir Chaika,
  • Tatiana Kalenik and
  • Kirill Golokhvast

13 October 2021

Vehicle emission particles (VEPs) represent a significant part of air pollution in urban areas. However, the toxicity of this category of particles in different aquatic organisms is still unexplored. This work aimed to extend the understanding of the...

  • Article
  • Open Access
13 Citations
3,606 Views
16 Pages

Prenatal Particulate Matter Exposure Is Associated with Saliva DNA Methylation at Age 15: Applying Cumulative DNA Methylation Scores as an Exposure Biomarker

  • Kelly M. Bakulski,
  • Jonah D. Fisher,
  • John F. Dou,
  • Arianna Gard,
  • Lisa Schneper,
  • Daniel A. Notterman,
  • Erin B. Ware and
  • Colter Mitchell

13 October 2021

Exposure in utero to particulate matter (PM2.5 and PM10) is associated with maladaptive health outcomes. Although exposure to prenatal PM2.5 and PM10 has cord blood DNA methylation signatures at birth, signature persistence into childhood and saliva...

  • Review
  • Open Access
12 Citations
3,847 Views
38 Pages

11 October 2021

Population and laboratory studies indicate that exposure to various forms of arsenic (As) is associated with many adverse health effects; therefore, methods are being sought out to reduce them. Numerous studies focus on the effects of nutrients on in...

  • Feature Paper
  • Article
  • Open Access
24 Citations
6,148 Views
18 Pages

Assessment of Environmental Pollution and Human Exposure to Pesticides by Wastewater Analysis in a Seven-Year Study in Athens, Greece

  • Nikolaos I. Rousis,
  • Maria Denardou,
  • Nikiforos Alygizakis,
  • Aikaterini Galani,
  • Anna A. Bletsou,
  • Dimitrios E. Damalas,
  • Niki C. Maragou,
  • Kevin V. Thomas and
  • Nikolaos S. Thomaidis

11 October 2021

Pesticides have been used in large amounts around the world for decades and are responsible for environmental pollution and various adverse effects on human health. Analysis of untreated wastewater can deliver useful information on pesticides’ use in...

  • Review
  • Open Access
17 Citations
4,289 Views
23 Pages

11 October 2021

Exposure to various forms of arsenic (As), the source of which may be environmental as well as occupational exposure, is associated with many adverse health effects. Therefore, methods to reduce the adverse effects of As on the human body are being s...

  • Feature Paper
  • Article
  • Open Access
33 Citations
4,940 Views
18 Pages

Lethal and Sublethal Responses of Hydropsyche pellucidula (Insecta, Trichoptera) to Commercial Polypropylene Microplastics after Different Preconditioning Treatments

  • Manuela Piccardo,
  • Marco Bertoli,
  • Paolo Pastorino,
  • Damià Barceló,
  • Francesca Provenza,
  • Davide Lesa,
  • Serena Anselmi,
  • Antonia Concetta Elia,
  • Marino Prearo and
  • Monia Renzi
  • + 1 author

9 October 2021

Microplastics (MPs) pose biological and chemical hazards in aquatic and terrestrial food webs across the globe. Research on microplastic contamination has long focused on marine ecosystems, whereas the toxicological impact on freshwater organisms is...

  • Review
  • Open Access
130 Citations
9,039 Views
26 Pages

Pharmaceutical Compounds in Aquatic Environments—Occurrence, Fate and Bioremediation Prospective

  • Joana P. Fernandes,
  • C. Marisa R. Almeida,
  • Maria A. Salgado,
  • Maria F. Carvalho and
  • Ana P. Mucha

9 October 2021

Various contaminants of emerging concern (CECs) have been detected in different ecosystems, posing a threat to living organisms and the environment. Pharmaceuticals are among the many CECs that enter the environment through different pathways, with w...

  • Article
  • Open Access
8 Citations
3,317 Views
19 Pages

Transcriptomic Analysis of Polyhexamethyleneguanidine-Induced Lung Injury in Mice after a Long-Term Recovery

  • Jeongah Song,
  • Kyung-Jin Jung,
  • Jae-Woo Cho,
  • Tamina Park,
  • Su-Cheol Han and
  • Daeui Park

8 October 2021

Polyhexamethyleneguanidine phosphate (PHMG-P) is one of the causative agents of humidifier disinfectant-induced lung injury. Direct exposure of the lungs to PHMG-P causes interstitial pneumonia with fibrosis. Epidemiological studies showed that patie...

  • Article
  • Open Access
12 Citations
3,125 Views
19 Pages

Application of ZnO-Nd Nano-Photocatalyst for the Reactive Red 198 Dye Decolorization in the Falling-Film Photocatalytic Reactor

  • Fatemeh Biglar,
  • Amirreza Talaiekhozani,
  • Farham Aminsharei,
  • Junboum Park,
  • Anahita Barghi and
  • Shahabaldin Rezania

8 October 2021

A large amount of Reactive red 198 (RR198) is released yearly into the environment. RR198 is toxic for human and aquatic creatures; therefore, it should be removed from wastewater before releasing into the environment. In this study, the nano ZnO-Nd...

  • Article
  • Open Access
13 Citations
3,477 Views
22 Pages

Type 2 Diabetes Mellitus Mediation by the Disruptive Activity of Environmental Toxicants on Sex Hormone Receptors: In Silico Evaluation

  • Franklyn Nonso Iheagwam,
  • Joseph Kelechi Odiba,
  • Olawumi Toyin Iheagwam,
  • Olubanke Olujoke Ogunlana and
  • Shalom Nwodo Chinedu

8 October 2021

This study investigates the disruptive activity of environmental toxicants on sex hormone receptors mediating type 2 diabetes mellitus (T2DM). Toxicokinetics, gene target prediction, molecular docking, molecular dynamics, and gene network analysis we...

  • Article
  • Open Access
4 Citations
4,180 Views
14 Pages

Exploring Neurobehaviour in Zebrafish Embryos as a Screening Model for Addictiveness of Substances

  • Anne Havermans,
  • Edwin P. Zwart,
  • Hans W. J. M. Cremers,
  • Maarten D. M. van Schijndel,
  • Romy S. Constant,
  • Maja Mešković,
  • Laura X. Worutowicz,
  • Jeroen L. A. Pennings,
  • Reinskje Talhout and
  • Harm J. Heusinkveld
  • + 1 author

7 October 2021

Tobacco use is the leading cause of preventable death worldwide and is highly addictive. Nicotine is the main addictive compound in tobacco, but less is known about other components and additives that may contribute to tobacco addiction. The zebrafis...

  • Feature Paper
  • Article
  • Open Access
24 Citations
15,149 Views
9 Pages

7 October 2021

A 43-year-old male, sport coach, presented him-self at the Emergency unit of a local hospital for epigastric pain, myalgia pain and severe headache. He claimed having used for some days a combination of GW1516 (cardarine), a peroxisome proliferator-a...

  • Article
  • Open Access
6 Citations
3,354 Views
20 Pages

Mercury Chloride Impacts on the Development of Erythrocytes and Megakaryocytes in Mice

  • Jinyi He,
  • Yifan Zhao,
  • Tingting Zhu,
  • Peng Xue,
  • Weiwei Zheng,
  • Ye Yao,
  • Weidong Qu,
  • Xiaodong Jia,
  • Rongzhu Lu and
  • Yubin Zhang
  • + 1 author

7 October 2021

Inorganic mercury (Hg2+) is a highly toxic heavy metal. The aim of this study was to investigate the impact of Hg2+ on the development of erythrocytes and megakaryocytes. B10.S mice (H-2s) and DBA/2 mice (H-2d) were administrated with 10 μM HgCl2 or...

  • Article
  • Open Access
23 Citations
5,421 Views
14 Pages

Analysis of Multi-Pesticide Residues and Dietary Risk Assessment in Fresh Tomatoes (Lycopersicum esculentum) from Local Supermarkets of the Metropolitan Region, Chile

  • Sebastian Elgueta,
  • Marcela Valenzuela,
  • Marcela Fuentes,
  • Pilar E. Ulloa,
  • Cecilia Ramos,
  • Arturo Correa and
  • Sebastian Molinett

6 October 2021

In recent years, the official authorities in Chile have reported transgressions in the maximum residue levels of pesticides in fresh vegetables. There is no official information about traceability, pesticide levels, and potential health risks. The ai...

  • Article
  • Open Access
14 Citations
4,056 Views
14 Pages

Solid-Phase Partitioning and Leaching Behavior of Pb and Zn from Playground Soils in Kabwe, Zambia

  • Walubita Mufalo,
  • Pawit Tangviroon,
  • Toshifumi Igarashi,
  • Mayumi Ito,
  • Tsutomu Sato,
  • Meki Chirwa,
  • Imasiku Nyambe,
  • Hokuto Nakata,
  • Shouta Nakayama and
  • Mayumi Ishizuka

4 October 2021

Zambia’s Kabwe mine wastes (KMWs) are responsible for contaminating the surrounding soil and dust in the Kabwe district. Unfortunately, these wastes arise from the historical mining activities of lead (Pb) and Zinc (Zn), which lacked adequate waste m...

  • Feature Paper
  • Article
  • Open Access
5 Citations
3,966 Views
17 Pages

Quantitative NanoLC/NSI+-HRMS Method for 1,3-Butadiene Induced bis-N7-guanine DNA-DNA Cross-Links in Urine

  • Luke Erber,
  • Samantha Goodman,
  • Caitlin C. Jokipii Krueger,
  • Ivan Rusyn and
  • Natalia Tretyakova

2 October 2021

1,3-Butadiene (BD) is a common environmental and industrial chemical widely used in plastic and rubber manufacturing and also present in cigarette smoke and automobile exhaust. BD is classified as a known human carcinogen based on evidence of carcino...

  • Review
  • Open Access
17 Citations
5,550 Views
13 Pages

Dichlorodiphenyltrichloroethane and the Adrenal Gland: From Toxicity to Endocrine Disruption

  • Ekaterina P. Timokhina,
  • Valentin V. Yaglov and
  • Svetlana V. Nazimova

1 October 2021

Endocrine disruptors are exogenous compounds that pollute the environment and have effects similar to hormones when inside the body. One of the most widespread endocrine disruptors in the wild is the pesticide dichlorodiphenyltrichloroethane (DDT). T...

  • Article
  • Open Access
11 Citations
3,858 Views
16 Pages

Transfer of Pollutants from Macrocystis pyrifera to Tetrapygus niger in a Highly Impacted Coastal Zone of Chile

  • Nicolás Latorre-Padilla,
  • Andrés Meynard,
  • Jorge Rivas and
  • Loretto Contreras-Porcia

1 October 2021

PAHs and heavy metals are characteristic pollutants in urbanized coastal areas, especially those with industrial activity. Given this context and the ability of Macrocystis pyrifera to drift when detached and provide trophic subsidy in coastal system...

  • Feature Paper
  • Article
  • Open Access
21 Citations
5,310 Views
21 Pages

Urinary Polycyclic Aromatic Hydrocarbon Metabolites Are Associated with Biomarkers of Chronic Endocrine Stress, Oxidative Stress, and Inflammation in Adolescents: FLEHS-4 (2016–2020)

  • Veerle J. Verheyen,
  • Sylvie Remy,
  • Eva Govarts,
  • Ann Colles,
  • Laura Rodriguez Martin,
  • Gudrun Koppen,
  • Stefan Voorspoels,
  • Liesbeth Bruckers,
  • Esmée M. Bijnens and
  • Greet Schoeters
  • + 13 authors

1 October 2021

Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants of public health concern. Multiple biological mechanisms have been hypothesized to contribute to PAHs-associated adverse health effects. Little is known about the impact of PAHs on...

  • Article
  • Open Access
61 Citations
7,618 Views
16 Pages

Levels of Phthalates, Bisphenol-A, Nonylphenol, and Microplastics in Fish in the Estuaries of Northern Taiwan and the Impact on Human Health

  • I-Cheng Lu,
  • How-Ran Chao,
  • Wan-Nurdiyana-Wan Mansor,
  • Chun-Wei Peng,
  • Yi-Chyun Hsu,
  • Tai-Yi Yu,
  • Wei-Hsiang Chang and
  • Lung-Ming Fu

1 October 2021

Due to the sparsity in knowledge, we investigated the presence of various estrogenic endocrine-disrupting chemicals (EEDCs), including phthalates (PAEs), bisphenol-A (BPA), and nonylphenol (NP), as well as microplastics (MPs) in samples of the most w...

  • Article
  • Open Access
3 Citations
2,748 Views
14 Pages

29 September 2021

There is limited evidence on the association between blood mercury (Hg) concentration and the risk of borderline dyslipidemia in adolescents. Here, we investigated the association between blood Hg concentration and the prevalence of borderline dyslip...

  • Feature Paper
  • Article
  • Open Access
28 Citations
5,471 Views
11 Pages

Analysis of Toxic Metals in Aerosols from Devices Associated with Electronic Cigarette, or Vaping, Product Use Associated Lung Injury

  • Nathalie Gonzalez-Jimenez,
  • Naudia Gray,
  • R. Steven Pappas,
  • Mary Halstead,
  • Erica Lewis,
  • Liza Valentin-Blasini,
  • Clifford Watson and
  • Benjamin Blount

29 September 2021

Research gaps exist in toxic metals characterization in e-cigarette, or vaping, products (EVPs) as these analytes typically have low concentrations and most standard aerosol trapping techniques have high metals background. An additional complication...

  • Article
  • Open Access
12 Citations
5,259 Views
17 Pages

Bioaccumulation of PCBs and PBDEs in Fish from a Tropical Lake Chapala, Mexico

  • Ernesto Oregel-Zamudio,
  • Dioselina Alvarez-Bernal,
  • Marina Olivia Franco-Hernandez,
  • Hector Rene Buelna-Osben and
  • Miguel Mora

29 September 2021

Lake Chapala is the largest natural freshwater reservoir in Mexico and the third largest lake in Latin America. Lakes are often considered the final deposit of polluting materials; they can be concentrated in the organisms that inhabit them, the wate...

  • Article
  • Open Access
6 Citations
3,498 Views
9 Pages

28 September 2021

Although there are several case reports showing that carbon monoxide (CO) poisoning causes ischemic heart disease (IHD), no large-scale epidemiological studies have shown a significant association between the two. To investigate the association betwe...

  • Feature Paper
  • Article
  • Open Access
22 Citations
3,957 Views
62 Pages

A Method Scope Extension for the Simultaneous Analysis of POPs, Current-Use and Banned Pesticides, Rodenticides, and Pharmaceuticals in Liver. Application to Food Safety and Biomonitoring

  • Cristian Rial-Berriel,
  • Andrea Acosta-Dacal,
  • Manuel Zumbado,
  • Luis Alberto Henríquez-Hernández,
  • Ángel Rodríguez-Hernández,
  • Ana Macías-Montes,
  • Luis D. Boada,
  • María del Mar Travieso-Aja,
  • Beatriz Martin Cruz and
  • Octavio P. Luzardo

27 September 2021

The screening of hundreds of substances belonging to multiple chemical classes in liver is required in areas such as food safety or biomonitoring. We adapted a previous QuEChERS-based method in blood to the liver matrix and applied to these fields of...

  • Feature Paper
  • Review
  • Open Access
37 Citations
9,131 Views
14 Pages

25 September 2021

Microbial transglutaminase (mTG) is a heavily used food additive and its industrial transamidated complexes usage is rising rapidly. It was classified as a processing aid and was granted the GRAS (generally recognized as safe) definition, thus escapi...

  • Article
  • Open Access
13 Citations
3,524 Views
14 Pages

25 September 2021

The •OH and SO4•− play a vital role on degrading pharmaceutical contaminants in water. In this paper, theoretical calculations have been used to discuss the degradation mechanisms, kinetics and ecotoxicity of acetaminophen (AAP) initiated by •OH and...

  • Feature Paper
  • Article
  • Open Access
23 Citations
5,704 Views
26 Pages

25 September 2021

Studies have shown that aerosols generated from flavored e-cigarettes contain Reactive Oxygen Species (ROS), promoting oxidative stress-induced damage within pulmonary cells. Our lab investigated the ROS content of e-cigarette vapor generated from di...

  • Article
  • Open Access
38 Citations
10,153 Views
24 Pages

25 September 2021

During the recent decades, the world has seen ongoing economic and technological development which resulted in the generation of huge volumes of electrical and electronic waste (e-waste). In the Middle East, the United Arab Emirates (UAE) ranks among...

  • Feature Paper
  • Article
  • Open Access
27 Citations
5,206 Views
15 Pages

The Peculiar Estrogenicity of Diethyl Phthalate: Modulation of Estrogen Receptor α Activities in the Proliferation of Breast Cancer Cells

  • Marco Fiocchetti,
  • Giovanna Bastari,
  • Manuela Cipolletti,
  • Stefano Leone,
  • Filippo Acconcia and
  • Maria Marino

25 September 2021

Phthalates comprise a group of synthetic chemicals present in the environment because of their wide use as plasticizers and as additives in products for personal care. Among others, diethyl phthalate (DEP) is largely used in products for infants, chi...

  • Feature Paper
  • Article
  • Open Access
25 Citations
5,133 Views
17 Pages

Degradation of 2,4,6-Trinitrotoluene (TNT): Involvement of Protocatechuate 3,4-Dioxygenase (P34O) in Buttiauxella sp. S19-1

  • Miao Xu,
  • Dong Liu,
  • Ping Sun,
  • Yunuo Li,
  • Ming Wu,
  • Wencong Liu,
  • Edmund Maser,
  • Guangming Xiong and
  • Liquan Guo

24 September 2021

Extensive use and disposal of 2,4,6-trinitrotoluene (TNT), a primary constituent of explosives, pollutes the environment and causes severe damage to human health. Complete mineralization of TNT via bacterial degradation has recently gained research i...

  • Communication
  • Open Access
4 Citations
5,777 Views
12 Pages

24 September 2021

An imbalance between reactive oxygen species (ROS) and antioxidants in a living organism results in oxidative stress. Measures of such imbalance can be used as a biomarker of stress in ecotoxicology. In this study, we implemented the ROS detection me...

  • Feature Paper
  • Article
  • Open Access
11 Citations
6,994 Views
19 Pages

23 September 2021

Nitrosamines can be produced during the manufacture of rubber-type products such as pacifiers or the nipples of baby bottles. Humans can be exposed to the nitrosamines in these products when they are eluted into saliva. In this study, we compared the...

  • Feature Paper
  • Review
  • Open Access
146 Citations
17,442 Views
13 Pages

22 September 2021

Peripheral neuropathy is one of the most common side effects of chemotherapy, affecting up to 60% of all cancer patients receiving chemotherapy. Moreover, paclitaxel induces neuropathy in up to 97% of all gynecological and urological cancer patients....

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Toxics - ISSN 2305-6304