Special Issue "Plasticizer Exposure: Harmful Impact on Human Health"

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Risk Assessment and Management".

Deadline for manuscript submissions: 30 April 2022.

Special Issue Editor

Dr. Po-Chin Huang
E-Mail Website
Guest Editor
1 National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan
2 Department of Safety, Health and Environmental Engineering, National United University, Miaoli, Taiwan
3 Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
4 Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
5 Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan
Interests: epidemiology; exposure science; biomonitoring; risk assessment; biomarker

Special Issue Information

Dear Colleagues,

Plasticizers, including phthalates, bisphenols, and their substitutes, have been widely used all over the world in the past several decades. Human exposure to plasticizers increased with the ubiquitous use of plastic products, food containers, toys, medicines, building materials, electronic devices, cosmetics, perfumes, personal care products, etc. in our daily life. Some plasticizers have been classified as endocrine-disrupting chemicals (EDCs) by US and EU scientists and governments due to their ability to disrupt animal and human endocrine systems. Increasing mechanistic and epidemiological studies suggest that low-dose and long-term plasticizer exposure may be associated with endocrinal, reproductive, and neurological effects, and several chronic diseases in different populations. Meanwhile, the latest human biomonitoring data reveals increased levels of plasticizer substitutes in the general population, making the assessment of their potential health impacts worthwhile. This Special Issue is focused on the potential health impacts of human exposure to plasticizers and their substitutes.

Dr. Po-Chin Huang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plasticizers
  • substitutes
  • endocrine-disrupting chemicals
  • health assessment

Published Papers (1 paper)

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Research

Article
Association between Urinary Phthalate Metabolites and Markers of Endothelial Dysfunction in Adolescents and Young Adults
Toxics 2021, 9(2), 33; https://doi.org/10.3390/toxics9020033 - 06 Feb 2021
Viewed by 847
Abstract
Endothelial function is crucial in the pathogenesis of circulatory and cardiovascular toxicity; epidemiologic research investigating the association between phthalate exposure and endothelial dysfunction remains limited. We examined the associations between exposures to specific phthalates (di-2-ethylhexyl phthalate, DEHP; di-n-butyl phthalate, DnBP) and circulating endothelial [...] Read more.
Endothelial function is crucial in the pathogenesis of circulatory and cardiovascular toxicity; epidemiologic research investigating the association between phthalate exposure and endothelial dysfunction remains limited. We examined the associations between exposures to specific phthalates (di-2-ethylhexyl phthalate, DEHP; di-n-butyl phthalate, DnBP) and circulating endothelial and platelet microparticles (EMPs and PMPs) in adolescents and young adults. Of the 697 participants recruited, anthropometric measurements and health-related behaviors relevant to cardiovascular risks were collected and assessed. Urine and serum were collected and analyzed with liquid chromatography-tandem mass spectrometry (LC-MS/MS) and flow cytometry. Multiple linear regression indicated that increases in urinary concentrations of ΣDEHP and MnBP (mono-n-butyl phthalate), across quartiles, were positively associated with serum EMPs level (p for trend <0.001 and <0.001; β = 0.798 and 0.007; standard error = 0.189 and 0.001, respectively). Moreover, female and overweight subjects had higher MnBP, and males were more vulnerable to DnBP exposure compared to females. In conclusion, our results demonstrate a dose-response relationship between exposures to phthalates (ΣDEHP and MnBP) and microparticle formation (EMPs and PMPs) in adolescents and young adults. The findings indicate that exposures to phthalates of both low and high-molecular weight are positively associated with microparticle production, and might contribute to endothelial dysfunction; such damage might manifest in the form of atherosclerotic-related vascular diseases. Future in vivo and in vitro studies are warranted to elucidate whether a causal relationship exists between phthalate exposure and EMPs and PMPs. Full article
(This article belongs to the Special Issue Plasticizer Exposure: Harmful Impact on Human Health)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

1. Bioaccumulation and occurrence of phthalates, bisphenol-A, nonylphenol, and microplastics in fish from the north Taiwan estuary system and their impact on human health
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