Developmental Environmental Exposures, Epigenetics and Long-Term Health
A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Reproductive and Developmental Toxicity".
Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 17236
Special Issue Editor
Interests: toxicology; developmental origins of health and disease; toxicoepigenetics; sex differences; metabolomics; stem cells; cardiovascular disease; nutrient–toxicant interactions
Special Issue Information
Dear Colleagues,
It is increasingly evident that environmental exposures during critical windows of development can impact human health across one’s lifespan. Developmental exposures linked to adverse health effects include heavy metals (lead, cadmium, arsenic), endocrine disruptors (phthalates, bisphenols, per- and polyfluoroalkyl substances (PFAS)), air pollutants (tobacco smoke, ozone, particulate matter) and radiation. Normal development is governed by widespread epigenomic reprogramming in the somatic cells and primordial germ cells of the developing embryo. This reprogramming includes changes in DNA methylation, DNA hydroxymethylation, chromatin modification/structure, and expression/function of noncoding RNAs. Epigenetic changes continue during the postnatal period, early childhood, and adolescence. An important mechanism by which early environmental exposures may affect long-term health is through interfering with these critical developmental processes. The effects of environmental agents on epigenomic programming during critical periods of development, and the implications these changes have for health across the lifespan, are incompletely understood.
In this Special Issue, we invite contributions (original articles, reviews, and communications) that address these important research questions. These include mechanistic studies conducted in a variety of models (animal, cell culture, human tissues), as well as human epidemiologic studies. Of particular interest are studies that address the sex-specific effects of develomental environmental exposures on the epigenome and health.
Dr. Laurie Svoboda
Guest Editor
Manuscript Submission Information
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Keywords
- developmental origins of health and disease (DOHaD)
- epigenetics
- toxicoepigenetics
- DNA methylation
- DNA hydroxymethylation
- chromatin
- environmental health
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