Special Issue "Developmental Environmental Exposures, Epigenetics and Long-Term Health"
Deadline for manuscript submissions: closed (30 April 2021).
Interests: toxicology; developmental origins of health and disease; toxicoepigenetics; sex differences; metabolomics; stem cells; cardiovascular disease; nutrient–toxicant interactions
It is increasingly evident that environmental exposures during critical windows of development can impact human health across one’s lifespan. Developmental exposures linked to adverse health effects include heavy metals (lead, cadmium, arsenic), endocrine disruptors (phthalates, bisphenols, per- and polyfluoroalkyl substances (PFAS)), air pollutants (tobacco smoke, ozone, particulate matter) and radiation. Normal development is governed by widespread epigenomic reprogramming in the somatic cells and primordial germ cells of the developing embryo. This reprogramming includes changes in DNA methylation, DNA hydroxymethylation, chromatin modification/structure, and expression/function of noncoding RNAs. Epigenetic changes continue during the postnatal period, early childhood, and adolescence. An important mechanism by which early environmental exposures may affect long-term health is through interfering with these critical developmental processes. The effects of environmental agents on epigenomic programming during critical periods of development, and the implications these changes have for health across the lifespan, are incompletely understood.
In this Special Issue, we invite contributions (original articles, reviews, and communications) that address these important research questions. These include mechanistic studies conducted in a variety of models (animal, cell culture, human tissues), as well as human epidemiologic studies. Of particular interest are studies that address the sex-specific effects of develomental environmental exposures on the epigenome and health.
Dr. Laurie Svoboda
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- developmental origins of health and disease (DOHaD)
- DNA methylation
- DNA hydroxymethylation
- environmental health