Special Issue "Toxicity, Mechanism, and Health Effect of Metals and Their Detoxification Strategies"

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Ecotoxicology".

Deadline for manuscript submissions: 28 February 2022.

Special Issue Editor

Prof. Dr. Vijay Kumar
E-Mail Website
Guest Editor
Department of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk 38541, Korea
Interests: toxicity; antioxidant compounds; metal accumulation; oxidative stress; pathophysiology of metal toxicity; genetic and nutritional influence of metal toxicity outcomes; metal induced neurotoxicity; metal induced cardiotoxicity; metal toxicity associated disease; detoxification strategies
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Special Issue Information

Dear Colleagues,

Extensive use of metals in industry, agriculture, and chemicals and domestically causes environmental contaminations. Continuous exposure to metals results in the accumulation of metals in various body organs. These metals induce oxidative stress, inflammation, and apoptosis, which leads to tissue and organ damage. Reactive oxygen and nitrogen species were generated via metal toxicity, which activates/suppresses different apoptotic and inflammatory pathways. Metal toxicity is associated with various diseases, including neurological disorder, cardiac disease, cancer, etc.

Chelation therapy is one of the best-suggested treatment strategies in the case of metal toxicity. Many chelating agents are approved by the Food and Drug Administration (FDA) and some are under clinical trials. Many natural molecules/compounds were tested in vivo and in vitro and some compounds show beneficial outcomes.

This Special Issue aims to explore the following issues:

(1) The accumulation of metals in humans;

(2) Pathophysiology of metal toxicity;

(3) Metal toxicity associated disease;

(4) Detoxification strategies.

Prof. Dr. Vijay Kumar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Metal toxicity
  • Oxidative stress
  • Reactive oxygen species (ROS)
  • Heavy metal accumulation in Humans
  • Detoxification
  • Chelation therapy/Chelating agent
  • Metal associated diseases
  • Metal transporters
  • Metabolic syndrome

Published Papers (2 papers)

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Research

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Article
Coordination Properties of the Fungal Metabolite Harzianic Acid Toward Toxic Heavy Metals
Toxics 2021, 9(2), 19; https://doi.org/10.3390/toxics9020019 - 20 Jan 2021
Cited by 2 | Viewed by 595
Abstract
Some Trichoderma strains are known for their capacity to produce harzianic acid, a metabolite belonging to the tetramic acid derivatives. Harzianic acid has interesting biological properties, such as antimicrobial activities against phytopathogenic fungi and promotion of plant growth. It also possesses remarkable chemical [...] Read more.
Some Trichoderma strains are known for their capacity to produce harzianic acid, a metabolite belonging to the tetramic acid derivatives. Harzianic acid has interesting biological properties, such as antimicrobial activities against phytopathogenic fungi and promotion of plant growth. It also possesses remarkable chemical properties, including the chelating properties toward essential transition metals, which might be related to the biological activities. Increasing knowledge on chelating properties might be relevant for understanding the various beneficial effects of harzianic acid in the interaction between the producer fungi and plants. In this work, the coordination capacity of harzianic acid was studied to evaluate the formation and stability of complexes formed with toxic heavy metals (i.e., Cd2+, Co2+, Ni2+, and Pb2+), which might have a crucial role in the tolerance of plants growing in metal-contaminated soils and in abiotic stress. Full article
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Review

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Review
Cognitive Impairment Induced by Lead Exposure during Lifespan: Mechanisms of Lead Neurotoxicity
Toxics 2021, 9(2), 23; https://doi.org/10.3390/toxics9020023 - 28 Jan 2021
Cited by 5 | Viewed by 929
Abstract
Lead (Pb) is considered a strong environmental toxin with human health repercussions. Due to its widespread use and the number of people potentially exposed to different sources of this heavy metal, Pb intoxication is recognized as a public health problem in many countries. [...] Read more.
Lead (Pb) is considered a strong environmental toxin with human health repercussions. Due to its widespread use and the number of people potentially exposed to different sources of this heavy metal, Pb intoxication is recognized as a public health problem in many countries. Exposure to Pb can occur through ingestion, inhalation, dermal, and transplacental routes. The magnitude of its effects depends on several toxicity conditions: lead speciation, doses, time, and age of exposure, among others. It has been demonstrated that Pb exposure induces stronger effects during early life. The central nervous system is especially vulnerable to Pb toxicity; Pb exposure is linked to cognitive impairment, executive function alterations, abnormal social behavior, and fine motor control perturbations. This review aims to provide a general view of the cognitive consequences associated with Pb exposure during early life as well as during adulthood. Additionally, it describes the neurotoxic mechanisms associated with cognitive impairment induced by Pb, which include neurochemical, molecular, and morphological changes that jointly could have a synergic effect on the cognitive performance. Full article
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