Table of Contents
Processes, Volume 7, Issue 7 (July 2019)
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Cover Story (view full-size image) The gut microbiota is a heterogeneous group of microbes spatially distributed along various [...] Read more. The gut microbiota is a heterogeneous group of microbes spatially distributed along various sections of the intestines and across the mucosa and lumen in each section. Understanding the dynamics between the spatially differential microbial populations will provide valuable insights into the gut microbiome and intestinal health. We developed a dynamic framework using genome-scale metabolic models to predict the spatially differential microbiota composition and metabolism. We were able to capture the essential features of the spatially differential composition of anaerobes vs. aerobes and found that the spatial organization depends primarily on the oxygen-per-microbe availability in each region. View this paper.