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Open AccessArticle

Choline-Based Ionic Liquids as Media for the Growth of Saccharomyces cerevisiae

1
Centre of Research in Ionic Liquids (CORIL), Universiti Teknologi PETRONAS, Bandar Seri Iskandar 32610, Perak, Malaysia
2
Department of Fundamental and Applied Science, Universiti Teknologi PETRONAS, Bandar Seri Iskandar 32610, Perak, Malaysia
3
Department of Chemical and Environmental Engineering/Sustainable Process Engineering Research Centre (SPERC), Faculty of Engineering, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia
*
Author to whom correspondence should be addressed.
Processes 2019, 7(7), 471; https://doi.org/10.3390/pr7070471
Received: 9 April 2019 / Revised: 13 June 2019 / Accepted: 13 June 2019 / Published: 22 July 2019
(This article belongs to the Section Green Processes)
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Abstract

Ionic liquids (ILs) have garnered great attention as alternative solvents in many biological reactions and applications. However, its unknown toxicity is in line with the challenges to use it for biological applications. In this study, three choline based Ionic Liquids—choline saccharinate (CS), choline dihydrogen phosphate (CDHP), and choline tryptophanate (CT) were assessed for their suitability on the growth of Saccharomyces cerevisiae. The ILs were incorporated into the growth media of S. cerevisiae (defined as synthetic media) to access its potential as a substitute to conventional media. The compatibility of the synthetic media was evaluated based on the toxicity (EC50), growth curve, and glucose profile. The results showed that the incorporation of CDHP and CS did promote the growth of S. cerevisiae with a rapid glucose consumption rate. The growth of S. cerevisiae with the media composition of yeast extract, peptone, and CS showed improvement of 13%. We believe that these observations have implications in the biocompatibility studies of ILs to microorganisms. View Full-Text
Keywords: biotoxicity; choline; ionic liquids; Saccharomyces cerevisiae biotoxicity; choline; ionic liquids; Saccharomyces cerevisiae
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Sivapragasam, M.; Wilfred, C.D.; Jaganathan, J.R.; Krishnan, S.; Ab Wan Karim Ghani, W.A.W. Choline-Based Ionic Liquids as Media for the Growth of Saccharomyces cerevisiae. Processes 2019, 7, 471.

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