Table of Contents
Metabolites, Volume 9, Issue 3 (March 2019)
- Issues are regarded as officially published after their release is announced to the table of contents alert mailing list.
- You may sign up for e-mail alerts to receive table of contents of newly released issues.
- PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.
Cover Story (view full-size image) In this article, we explore the hypothesis that there are metabolic differences between children on [...] Read more. In this article, we explore the hypothesis that there are metabolic differences between children on schedule versus those not on schedule for normal communication skills development; and that these differences may provide early indicators of Autism Spectrum Disorders (ASD) risk. We demonstrate that metabolomic differences are detectable from age one, and that they can be observed in both the stool and the plasma. Our findings suggest dysregulation of the pathways of tryptophan, tyrosine and endocannabinoid metabolism, which have all been shown to be involved in ASD, largely though their roles in neuromodulation. These results provide evidence that communication skills development has systematic manifestations outside the blood-brain barrier and therefore metabolomic profiling may provide alternative approaches for early diagnosis of ASD, as well as insights into their pathobiology. View this paper.