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Critical Review of Volatile Organic Compound Analysis in Breath and In Vitro Cell Culture for Detection of Lung Cancer

1
NUSNNI-Nanocore, National University of Singapore, Singapore 117411, Singapore
2
NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 117456, Singapore
3
Department of Electrical Engineering, National University of Singapore, Singapore 117583, Singapore
4
Department of Materials Science and Engineering, National University of Singapore, Singapore 117574, Singapore
5
Department of Physics, National University of Singapore, Singapore 117581, Singapore
*
Author to whom correspondence should be addressed.
Metabolites 2019, 9(3), 52; https://doi.org/10.3390/metabo9030052
Received: 10 January 2019 / Revised: 11 March 2019 / Accepted: 13 March 2019 / Published: 18 March 2019
(This article belongs to the Special Issue Cancer Metabolomics 2018)
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PDF [705 KB, uploaded 18 March 2019]
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Abstract

Breath analysis is a promising technique for lung cancer screening. Despite the rapid development of breathomics in the last four decades, no consistent, robust, and validated volatile organic compound (VOC) signature for lung cancer has been identified. This review summarizes the identified VOC biomarkers from both exhaled breath analysis and in vitro cultured lung cell lines. Both clinical and in vitro studies have produced inconsistent, and even contradictory, results. Methodological issues that lead to these inconsistencies are reviewed and discussed in detail. Recommendations on addressing specific issues for more accurate biomarker studies have also been made. View Full-Text
Keywords: volatile organic compound; lung cancer; breath analysis; in vitro study; biomarker volatile organic compound; lung cancer; breath analysis; in vitro study; biomarker
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Jia, Z.; Patra, A.; Kutty, V.K.; Venkatesan, T. Critical Review of Volatile Organic Compound Analysis in Breath and In Vitro Cell Culture for Detection of Lung Cancer. Metabolites 2019, 9, 52.

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