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Metabolites, Volume 15, Issue 9

September 2025 - 74 articles

Cover Story: Sepsis-induced mitochondrial dysfunction is a key driver of organ failure. This study explores the protective role of cyclophilin D (CypD) knockout in a murine sepsis model. Metabolomic analysis of liver tissue revealed that CypD-deficient mice were protected from metabolic collapse. Unlike wild-type mice, they maintained stable lactate levels, indicating preserved mitochondrial function. Crucially, these mice exhibited significantly elevated levels of antioxidants (glutathione disulfide, spermidine) and a marked reduction in oxidative stress. These findings demonstrate that CypD deficiency enhances mitochondrial resistance to sepsis, safeguarding metabolic and redox balance. Targeting CypD to inhibit mitochondrial permeability transition is thus a promising therapeutic strategy against sepsis. View this paper
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Articles (74)

  • Article
  • Open Access
1 Citations
553 Views
11 Pages

19 September 2025

Purpose: To explore the potential relationship between salivary amino acid concentrations and 8 km running performance in male undergraduate students. Methods: Thirty male undergraduate students were recruited. Participants completed an 8 km run whil...

  • Review
  • Open Access
1 Citations
2,042 Views
36 Pages

Dietary Modulation of Metabolic Health: From Bioactive Compounds to Personalized Nutrition

  • Aleksandra Leziak,
  • Julia Lipina,
  • Magdalena Reclik and
  • Piotr Kocelak

19 September 2025

Metabolic health is a dynamic equilibrium influenced by diet and lifestyle. This review synthesizes evidence on how specific dietary patterns and bioactive nutrients modulate metabolic disorders. Diets like the Mediterranean and DASH plans consistent...

  • Article
  • Open Access
3,459 Views
16 Pages

High-Intensity Interval Training (HIIT): Impact of Duration on Body Composition, Cardiometabolic Health, and Aerobic Capacity in Adolescent Women

  • Mima Stankovic,
  • Ilma Čaprić,
  • Luka Pezelj,
  • Emir Biševac,
  • Raid Mekić,
  • Armin Zećirović,
  • Zerina Salihagić,
  • Aldina Ajdinović and
  • Igor Jelaska

19 September 2025

Background: High-intensity interval training (HIIT) is a time-efficient approach that has been recognized to enhance cardiometabolic health and aerobic capacity in adolescents. The purpose of this study was to investigate the effects of various HIIT...

  • Article
  • Open Access
686 Views
18 Pages

The Effect of 9-Week Dietary Intervention on Anthropometric Parameters and Blood Pressure in Children with Excessive Body Weight

  • Karolina Gajda,
  • Marta Jeruszka-Bielak,
  • Magdalena Górnicka,
  • Irena Keser and
  • Jadwiga Hamulka

18 September 2025

Background/Objectives: The prevalence of pediatric overweight and obesity is steadily increasing, posing a tremendous problem and challenge to public health. Various strategies have been undertaken to combat this issue with mixed results. This study...

  • Article
  • Open Access
910 Views
24 Pages

NMR-Based Metabolomic Profiling Highlights Functional Nutritional Gaps Between Human Milk, Infant Formulas, and Animal Milks

  • Gaia Meoni,
  • Leonardo Tenori,
  • Giovanni Niero,
  • Massimo De Marchi and
  • Claudio Luchinat

18 September 2025

Background/Objectives: Human milk represents the gold standard for infant nutrition, providing a complex and bioactive metabolite profile essential for early development. Despite efforts to enrich infant and toddler formulas with functional ingredien...

  • Article
  • Open Access
559 Views
9 Pages

18 September 2025

Background: Gastrointestinal (GI) cancers are common and pose a major public health issue. An inflammatory microenvironment drives their development and progression. The α7nAChR receptor, known to suppress autoimmune and inflammatory bowel dise...

  • Article
  • Open Access
751 Views
17 Pages

Yigong San Extract Modulates Metabolism, Antioxidant Status, and Immune Function to Improve Health in Diarrheic Calves

  • Sijuan Huang,
  • Chao Han,
  • Jianyu Lv,
  • Xiaosong Zhang,
  • Xuan Ni,
  • Xin Wang,
  • Jianfei Wang,
  • Yunfei Ma and
  • Zhihui Hao

18 September 2025

Background/Objectives: Calf diarrhea is a serious health problem in dairy farming, which seriously affects their production performance in adulthood. Diarrhea in calves is usually treated with antibiotics, which may lead to issues of antibiotic resid...

  • Article
  • Open Access
773 Views
19 Pages

Comparative Proteomic Analysis of Extracellular Vesicles from Donkey Colostrum and Mature Milk

  • Simonetta Caira,
  • Sandra Buratta,
  • Silvia Vincenzetti,
  • Raffaella Latella,
  • Matteo Seccaroni,
  • Sabrina De Pascale,
  • Cristina Federici,
  • Luana Lugini,
  • Stefano Giovagnoli and
  • Anna Maria Salzano
  • + 3 authors

18 September 2025

Background/Objectives: Donkey milk (DM) has been considered a valuable alternative to human and bovine counterparts as well as to infant formulas. Milk extracellular vesicles (EVs) have been proposed to influence key biological processes. The purpose...

  • Article
  • Open Access
701 Views
14 Pages

Molecular Characterization, Identification of the Volatile Organic Compounds by GC–MS, and Assessment of the Cytotoxic Activity of Leaves of Pimenta dioica L. Merrill Trees from Mexico

  • Isis Montalvo-López,
  • María del Rosario García-Mateos,
  • Juan Martínez-Solís,
  • Ramón Marcos Soto-Hernández and
  • Ma Carmen Ybarra-Moncada

18 September 2025

Background: Pimenta dioica is a medicinal plant rich in various natural compounds, giving it significant potential for applications in the pharmaceutical, cosmetic, food, and agricultural industries. However, little is known about the metabolites pre...

  • Article
  • Open Access
744 Views
20 Pages

Targeted Isolation of Prenylated Flavonoids from Paulownia tomentosa Fruit Extracts via AI-Guided Workflow Integrating LC-UV-HRMS/MS

  • Tomas Rypar,
  • Lenka Molcanova,
  • Barbora Valkova,
  • Ema Hromadkova,
  • Christoph Bueschl,
  • Bernhard Seidl,
  • Karel Smejkal and
  • Rainer Schuhmacher

17 September 2025

Objectives: This study presents a versatile, AI-guided workflow for the targeted isolation and characterization of prenylated flavonoids from Paulownia tomentosa (Thunb.) Steud. (Paulowniaceae). Methods: The approach integrates established extraction...

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Metabolites - ISSN 2218-1989