Mass Spectrometry-Based Metabolomics in Health and Disease: Targeted Analysis and Its Trends
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 585
Special Issue Editors
Interests: metabolomics in critical care medicine; bacterial and viral diseases of the pulmonary system
Special Issues, Collections and Topics in MDPI journals
Interests: sarcoidosis; nontuberculous mycobacteria; bronchial epithelial cells; ex-vivo lung model; animal model of pulmonary diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metabolomics has become a crucial field for studying health and disease by providing insights into the biochemical processes behind physiological and pathological states. Mass spectrometry (MS) is a key analytical platform in metabolomics due to its sensitivity, specificity, and versatility. This Special Issue of Metabolites, titled "Mass Spectrometry-Based Metabolomics in Health and Disease: Targeted Analysis", emphasizes the targeted approach to quantifying specific metabolites. Unlike untargeted methods, targeted metabolomics offers precise and reliable measurements, making it particularly valuable for clinical research.
In health, targeted metabolomics helps investigate metabolic signatures linked to normal physiological processes, such as energy metabolism and immune function. In disease, it has revealed significant metabolic changes in conditions like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. MS advancements, including high-resolution MS and MS/MS, have further enhanced the ability to measure low-abundance metabolites crucial for understanding disease mechanisms.
Targeted MS-based metabolomics plays a vital role in clinical and translational research by accurately quantifying metabolites in biological samples like blood, urine, and tissues. This approach is crucial for identifying metabolic biomarkers that are essential for disease diagnosis, prognosis, and therapy monitoring. It also aids in understanding metabolic pathways, enabling researchers to track metabolites in networks of biochemical reactions. Targeted metabolomics, with its focus on specific molecules, reduces data complexity and enhances sensitivity, making it ideal for applications requiring precision.
By narrowing the scope to predefined molecules, targeted metabolomics offers enhanced sensitivity, reduced data complexity, and robust quantification, making it particularly suitable for clinical applications where precision is paramount.
This Special Issue presents research that leverages metabolomics to study metabolic wellness, discover biomarkers, and improve early detection strategies, paving the way for personalized health interventions and preventive care. In this Special Issue, we aim to provide an opportunity for researchers and experts in the field to share their new findings, methods, and ideas about metabolomics and health and diseases.
Dr. Mohammad Mehdi Banoei
Dr. Mehdi Mirsaeidi
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- mass spectrometry-based metabolomics
- targeted metabolomics
- health and disease
- precision medi-cine
- biomarker discovery
- metabolic pathways
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