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Article

Active Pulmonary Tuberculosis in Elderly Patients: A 2016–2019 Retrospective Analysis from an Italian Referral Hospital

1
Respiratory Infectious Diseases Unit, National Institute for Infectious Diseases “L. Spallanzani” IRCCS, 00149 Rome, Italy
2
Microbiology and Bio-Repository Unit, National Institute for Infectious Diseases “L. Spallanzani” IRCCS, 00149 Rome, Italy
3
Diagnostic Imaging Unit, National Institute for Infectious Diseases “L. Spallanzani” IRCCS, 00149 Rome, Italy
4
Clinical Epidemiology Unit, National Institute for Infectious Diseases “L. Spallanzani” IRCCS, 00149 Rome, Italy
*
Author to whom correspondence should be addressed.
These Authors contributed equally.
Antibiotics 2020, 9(8), 489; https://doi.org/10.3390/antibiotics9080489
Received: 27 June 2020 / Revised: 3 August 2020 / Accepted: 5 August 2020 / Published: 7 August 2020
(This article belongs to the Special Issue Mycobacterial Infections and Therapy)
Tuberculosis (TB) in the elderly (>65 years old) has increasingly become a global health problem. It has long been recognized that older people are vulnerable to developing tuberculosis. We retrospectively evaluated data from patients older than 65 years diagnosed with pulmonary TB admitted to the National Institute for Infectious Diseases L. Spallanzani, Rome, Italy, from 1 January 2016 to 31 December 2019. One hundred and six consecutive patients were diagnosed with pulmonary TB and 68% reported at least one comorbidity and 44% at least one of the TB risk-factors. Out of the 26 elderly patients who reported an adverse event, having risk factors for TB (O.R. (Odds Ratios) = 1.45; 95% CI 1.12–3.65) and the presence of cavities on Chest X-rays (O.R. = 1.42; 95% CI 1.08–2.73) resulted in being more likely to be associated with adverse events in elderly patients. Having weight loss (O.R. = 1.31; 95% CI 1.08–1.55) and dyspnea (O.R. = 1.23; 95% CI 1.13–1.41) resulted in being significant predictors of unsuccessful treatment outcome in elderly patients. Older people with TB represent a vulnerable group, with high mortality rate, with a challenging diagnosis. Hospitalizations in tertiary referral hospital with clinical expertise in TB management can be useful to improve the outcome of these fragile patients. View Full-Text
Keywords: tuberculosis (TB); elderly; outcome; adverse events; risk factors tuberculosis (TB); elderly; outcome; adverse events; risk factors
MDPI and ACS Style

Di Gennaro, F.; Vittozzi, P.; Gualano, G.; Musso, M.; Mosti, S.; Mencarini, P.; Pareo, C.; Di Caro, A.; Schininà, V.; Girardi, E.; Palmieri, F. Active Pulmonary Tuberculosis in Elderly Patients: A 2016–2019 Retrospective Analysis from an Italian Referral Hospital. Antibiotics 2020, 9, 489. https://doi.org/10.3390/antibiotics9080489

AMA Style

Di Gennaro F, Vittozzi P, Gualano G, Musso M, Mosti S, Mencarini P, Pareo C, Di Caro A, Schininà V, Girardi E, Palmieri F. Active Pulmonary Tuberculosis in Elderly Patients: A 2016–2019 Retrospective Analysis from an Italian Referral Hospital. Antibiotics. 2020; 9(8):489. https://doi.org/10.3390/antibiotics9080489

Chicago/Turabian Style

Di Gennaro, Francesco, Pietro Vittozzi, Gina Gualano, Maria Musso, Silvia Mosti, Paola Mencarini, Carlo Pareo, Antonino Di Caro, Vincenzo Schininà, Enrico Girardi, and Fabrizio Palmieri. 2020. "Active Pulmonary Tuberculosis in Elderly Patients: A 2016–2019 Retrospective Analysis from an Italian Referral Hospital" Antibiotics 9, no. 8: 489. https://doi.org/10.3390/antibiotics9080489

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