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Antibiotics, Volume 9, Issue 6

June 2020 - 85 articles

Cover Story: Invasive fungal infections still constitute a major health problem, especially when affecting immunocompromised patients. A microbial natural products research program focused on the discovery of new antifungal compounds led to the identification and isolation of TKR 2999 from cultures of the fungus Foliophoma fallens, isolated from Pinus sp. using a dilution to extinction method. The structure of this lipodepsipeptide has been solved by spectroscopic and chemical methods and disclosed more than 20 years after its first report in a Japanese patent. The potent antifungal bioactivity of the molecule against Candida and Aspergillus species, the main pathogens causing fungal infections, has also been confirmed in our studies. Based on our results, Foliophoma has been identified as a genus to be added to the extensive list of fungal genera which are producers of interesting bioactive molecules. Vie

Articles (85)

  • Review
  • Open Access
14 Citations
7,425 Views
15 Pages

Methicillin-Resistant Staphylococcus aureus: Risk for General Infection and Endocarditis Among Athletes

  • Mariarita Brancaccio,
  • Cristina Mennitti,
  • Sonia Laneri,
  • Adelaide Franco,
  • Margherita G. De Biasi,
  • Arturo Cesaro,
  • Fabio Fimiani,
  • Elisabetta Moscarella,
  • Felice Gragnano and
  • Cristina Mazzaccara
  • + 9 authors

The first studies on Staphylococcus aureus (SA) infections in athletes were conducted in the 1980s, and examined athletes that perform in close physical contact, with particular attention to damaged or infected skin. Recent studies have used molecula...

  • Article
  • Open Access
16 Citations
4,281 Views
13 Pages

In Vitro Toxicity, Antioxidant, Anti-Inflammatory, and Antidiabetic Potential of Sphaerostephanos unitus (L.) Holttum

  • Marimuthu Alias Antonisamy Johnson,
  • C. Xavier Madona,
  • Ray S. Almeida,
  • Natália Martins and
  • Henrique D. M. Coutinho

Pteridophytes have been widely used in several systems of medicine. Several reports have increasingly assessed their bioactive effects, but for Sphaerostephanos unitus (L.) Holttum, only its antibacterial potential has been assessed. In this sense, t...

  • Article
  • Open Access
50 Citations
5,425 Views
16 Pages

Phytochemical Compositions and Biological Activities of Essential Oils from the Leaves, Rhizomes and Whole Plant of Hornstedtia bella Škorničk

  • Matthew Gavino Donadu,
  • Nhan Trong Le,
  • Duc Viet Ho,
  • Tuan Quoc Doan,
  • Anh Tuan Le,
  • Ain Raal,
  • Marianna Usai,
  • Mauro Marchetti,
  • Giuseppina Sanna and
  • Silvia Madeddu
  • + 9 authors

The rapid emergence of drug-resistant strains and novel viruses have motivated the search for new anti-infectious agents. In this study, the chemical compositions and cytotoxicity, as well as the antibacterial, antifungal, antitrichomonas, and antivi...

  • Article
  • Open Access
2 Citations
4,190 Views
12 Pages

Using GFP-Tagged Escherichia coli to Investigate the Persistence of Fecal Bacteria in Vegetated Wetlands: An Experimental Approach

  • Emilia Chiapponi,
  • Charles P. Henriot,
  • Xavier Bertrand,
  • Didier Hocquet and
  • Gudrun Bornette

The contamination of surface water by pathogenic bacteria of human origin is an important public health issue. Wetlands can be contaminated with fecal bacteria by water originating from different sources, such as wastewater treatment plants and agric...

  • Review
  • Open Access
40 Citations
6,551 Views
22 Pages

Metal–Peptide Complexes as Promising Antibiotics to Fight Emerging Drug Resistance: New Perspectives in Tuberculosis

  • Concetta Di Natale,
  • Ilaria De Benedictis,
  • Arianna De Benedictis and
  • Daniela Marasco

In metal-peptide interactions, cations form stable complexes through bonds with coordinating groups as side chains of amino acids. These compounds, among other things, exert a wide variety of antimicrobial activities through structural changes of pep...

  • Review
  • Open Access
85 Citations
7,879 Views
40 Pages

Stilbenoids: A Natural Arsenal against Bacterial Pathogens

  • Luce Micaela Mattio,
  • Giorgia Catinella,
  • Sabrina Dallavalle and
  • Andrea Pinto

The escalating emergence of resistant bacterial strains is one of the most important threats to human health. With the increasing incidence of multi-drugs infections, there is an urgent need to restock our antibiotic arsenal. Natural products are an...

  • Article
  • Open Access
17 Citations
5,423 Views
7 Pages

The objectives of this study were to report the antimicrobial susceptibility of 35 clinically significant anaerobic bacteria isolated from breast abscesses between March 2017 and February 2020 in a tertiary hospital in Granada (Spain) and to describe...

  • Article
  • Open Access
16 Citations
6,361 Views
21 Pages

The Basis for Natural Multiresistance to Phage in Pseudomonas aeruginosa

  • Christine Pourcel,
  • Cédric Midoux,
  • Gilles Vergnaud and
  • Libera Latino

Pseudomonas aeruginosa is responsible for long-term infections and is particularly resistant to treatments when hiding inside the extracellular matrix or biofilms. Phage therapy might represent an alternative to antibiotic treatment, but up to 10% of...

  • Article
  • Open Access
4 Citations
3,621 Views
9 Pages

Some of the most serious healthcare-associated infections (HAI) are highly deadly bloodstream infections (BSIs) caused by Staphylococcus aureus. The aim of the study was to analyse compliance of treatment practice with clinical guidelines in patients...

  • Review
  • Open Access
44 Citations
8,141 Views
27 Pages

Alkaloids from Marine Fungi: Promising Antimicrobials

  • Thomas Willems,
  • Maarten L. De Mol,
  • Aleksandar De Bruycker,
  • Sofie L. De Maeseneire and
  • Wim K. Soetaert

Resistance of pathogenic microorganisms against antimicrobials is a major threat to contemporary human society. It necessitates a perpetual influx of novel antimicrobial compounds. More specifically, Gram− pathogens emerged as the most exigent...

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Antibiotics - ISSN 2079-6382