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Antibiotics, Volume 9, Issue 6

June 2020 - 85 articles

Cover Story: Invasive fungal infections still constitute a major health problem, especially when affecting immunocompromised patients. A microbial natural products research program focused on the discovery of new antifungal compounds led to the identification and isolation of TKR 2999 from cultures of the fungus Foliophoma fallens, isolated from Pinus sp. using a dilution to extinction method. The structure of this lipodepsipeptide has been solved by spectroscopic and chemical methods and disclosed more than 20 years after its first report in a Japanese patent. The potent antifungal bioactivity of the molecule against Candida and Aspergillus species, the main pathogens causing fungal infections, has also been confirmed in our studies. Based on our results, Foliophoma has been identified as a genus to be added to the extensive list of fungal genera which are producers of interesting bioactive molecules. Vie

Articles (85)

  • Article
  • Open Access
5 Citations
4,315 Views
9 Pages

The number of reports of Malassezia furfur bloodstream infections is constantly increasing and there is a need for more simple antifungal susceptibility methods for their management. In this study, a total of 39 M. furfur isolates collected from hosp...

  • Article
  • Open Access
24 Citations
4,173 Views
14 Pages

N-Nonyloxypentyl-l-Deoxynojirimycin Inhibits Growth, Biofilm Formation and Virulence Factors Expression of Staphylococcus aureus

  • Eliana De Gregorio,
  • Anna Esposito,
  • Adriana Vollaro,
  • Maria De Fenza,
  • Daniele D’Alonzo,
  • Antonella Migliaccio,
  • Vita Dora Iula,
  • Raffaele Zarrilli and
  • Annalisa Guaragna

Staphylococcus aureus is one of the major causes of hospital- and community-associated bacterial infections throughout the world, which are difficult to treat due to the rising number of drug-resistant strains. New molecules displaying potent activit...

  • Article
  • Open Access
6 Citations
3,301 Views
12 Pages

Perioperative Antibiotic Prophylaxis: Knowledge and Attitudes among Resident Physicians in Italy

  • Concetta Paola Pelullo,
  • Angela Pepe,
  • Francesco Napolitano,
  • Nicola Coppola and
  • Gabriella Di Giuseppe

The aim of this study is to evaluate knowledge and attitudes on the perioperative antibiotic prophylaxis (PAP) among surgery and anesthesiology resident physicians in Italy. A Web-based national survey of Italian surgery and anesthesiology resident p...

  • Article
  • Open Access
16 Citations
6,220 Views
9 Pages

Anti-Bacterial Effects of Essential Oils against Uropathogenic Bacteria

  • Maria Loose,
  • Emmelie Pilger and
  • Florian Wagenlehner

Given the increasing antimicrobial resistance in urinary tract infections (UTI), alternative strategies need to be investigated. Determination of minimal inhibitory and bactericidal concentrations of essential oils from cajeput, lemongrass, tea tree,...

  • Article
  • Open Access
23 Citations
4,153 Views
14 Pages

Determination of Delafloxacin in Pharmaceutical Formulations Using a Green RP-HPTLC and NP-HPTLC Methods: A Comparative Study

  • Prawez Alam,
  • Essam Ezzeldin,
  • Muzaffar Iqbal,
  • Gamal A.E. Mostafa,
  • Md. Khalid Anwer,
  • Mohammed H. Alqarni,
  • Ahmed I. Foudah and
  • Faiyaz Shakeel

In this work; delafloxacin (DLFX) was determined using a validated green RP-HPTLC and NP-HPTLC methods in commercial tablets and in-house developed solid lipid nanoparticles (SLNs). RP-HPTLC determination of DLFX was performed using “RP-18 sili...

  • Article
  • Open Access
14 Citations
6,184 Views
16 Pages

Background: Inappropriate antibiotic treatments for urinary tract infections (UTIs) in nursing homes cause the development of resistant bacteria. Nonspecific symptoms and asymptomatic bacteriuria are drivers of overtreatment. Nursing home staff provi...

  • Communication
  • Open Access
37 Citations
5,446 Views
11 Pages

Helicobacter pylori Biofilm Confers Antibiotic Tolerance in Part via A Protein-Dependent Mechanism

  • Skander Hathroubi,
  • Julia Zerebinski,
  • Aaron Clarke and
  • Karen M. Ottemann

Helicobacter pylori, a WHO class I carcinogen, is one of the most successful human pathogens colonizing the stomach of over 4.4 billion of the world’s population. Antibiotic therapy represents the best solution but poor response rates have hamp...

  • Brief Report
  • Open Access
7 Citations
3,109 Views
8 Pages

Structural Modifications of 3-Triazeneindoles and Their Increased Activity Against Mycobacterium tuberculosis

  • Konstantin B. Majorov,
  • Boris V. Nikonenko,
  • Pavel Yu. Ivanov,
  • Lyudmila N. Telegina,
  • Alexander S. Apt and
  • Valeria S. Velezheva

We synthesized 100 novel indole-based compounds with polyaza-functionalities, including 3-triazeneindoles, and tested their activity in vitro against laboratory M. tuberculosis H37Rv and clinical izoniazid-resistant CN-40 isolates, using gross and fi...

  • Article
  • Open Access
20 Citations
4,162 Views
25 Pages

Venoms from ants comprise a rich source of bioactive peptides, including antimicrobial peptides. From the proteome and peptidome of the giant ant Dinoponera quadriceps venom, members of five known classes of antimicrobial peptides were disclosed (e.g...

  • Review
  • Open Access
152 Citations
26,016 Views
25 Pages

Bioactive Compounds, Pharmacological Actions, and Pharmacokinetics of Wormwood (Artemisia absinthium)

  • Gaber El-Saber Batiha,
  • Ahmed Olatunde,
  • Amany El-Mleeh,
  • Helal F. Hetta,
  • Salim Al-Rejaie,
  • Saad Alghamdi,
  • Muhammad Zahoor,
  • Amany Magdy Beshbishy,
  • Toshihiro Murata and
  • Adrian Zaragoza-Bastida
  • + 1 author

Plants have been used since ancient times to cure certain infectious diseases, and some of them are now standard treatments for several diseases. Due to the side effects and resistance of pathogenic microorganisms to antibiotics and most drugs on the...

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Antibiotics - ISSN 2079-6382Creative Common CC BY license