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Alkaloids from Marine Fungi: Promising Antimicrobials

Centre for Industrial Biotechnology and Biocatalysis (InBio.be), Department of Biotechnology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Antibiotics 2020, 9(6), 340; https://doi.org/10.3390/antibiotics9060340
Received: 29 May 2020 / Revised: 12 June 2020 / Accepted: 15 June 2020 / Published: 18 June 2020
Resistance of pathogenic microorganisms against antimicrobials is a major threat to contemporary human society. It necessitates a perpetual influx of novel antimicrobial compounds. More specifically, Gram pathogens emerged as the most exigent danger. In our continuing quest to search for novel antimicrobial molecules, alkaloids from marine fungi show great promise. However, current reports of such newly discovered alkaloids are often limited to cytotoxicity studies and, moreover, neglect to discuss the enigma of their biosynthesis. Yet, the latter is often a prerequisite to make them available through sufficiently efficient processes. This review aims to summarize novel alkaloids with promising antimicrobial properties discovered in the past five years and produced by marine fungi. Several discovery strategies are summarized, and knowledge gaps in biochemical production routes are identified. Finally, links between the structure of the newly discovered molecules and their activity are proposed. Since 2015, a total of 35 new antimicrobial alkaloids from marine fungi were identified, of which 22 showed an antibacterial activity against Gram microorganisms. Eight of them can be classified as narrow-spectrum Gram antibiotics. Despite this promising ratio of novel alkaloids active against Gram microorganisms, the number of newly discovered antimicrobial alkaloids is low, due to the narrow spectrum of discovery protocols that are used and the fact that antimicrobial properties of newly discovered alkaloids are barely characterized. Alternatives are proposed in this review. In conclusion, this review summarizes novel findings on antimicrobial alkaloids from marine fungi, shows their potential as promising therapeutic candidates, and hints on how to further improve this potential. View Full-Text
Keywords: antimicrobial compounds; marine fungi; alkaloids; isolation; biosynthesis; structure–activity antimicrobial compounds; marine fungi; alkaloids; isolation; biosynthesis; structure–activity
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MDPI and ACS Style

Willems, T.; De Mol, M.L.; De Bruycker, A.; De Maeseneire, S.L.; Soetaert, W.K. Alkaloids from Marine Fungi: Promising Antimicrobials. Antibiotics 2020, 9, 340. https://doi.org/10.3390/antibiotics9060340

AMA Style

Willems T, De Mol ML, De Bruycker A, De Maeseneire SL, Soetaert WK. Alkaloids from Marine Fungi: Promising Antimicrobials. Antibiotics. 2020; 9(6):340. https://doi.org/10.3390/antibiotics9060340

Chicago/Turabian Style

Willems, Thomas, Maarten L. De Mol, Aleksandar De Bruycker, Sofie L. De Maeseneire, and Wim K. Soetaert 2020. "Alkaloids from Marine Fungi: Promising Antimicrobials" Antibiotics 9, no. 6: 340. https://doi.org/10.3390/antibiotics9060340

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