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Antibiotics, Volume 14, Issue 7

July 2025 - 110 articles

Cover Story: Platelet concentrates (PCs), used to treat patients with bleeding disorders, are stored at 20–24 °C to maintaining platelet functionality. These conditions also sustain the growth of bacteria such as Staphylococcus aureus, which poses an important safety risk to transfusion patients as it reaches clinically significant levels and produces virulence factors during PC storage. Previous studies have demonstrated that Staphylococcus spp. grown in PCs display upregulation of genes encoding for antimicrobial resistance and virulence. To expand the current knowledge, this study aimed to test whether the increase in the norB efflux pump expression observed in PCs translates into heightened quinolone resistance. Furthermore, the role of the NorB efflux pump on S. aureus virulence was investigated using a Bombyx mori (silkworm) animal model. View this paper
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Articles (110)

  • Article
  • Open Access
2 Citations
2,301 Views
21 Pages

Mechanisms of Cefiderocol Resistance in Carbapenemase-Producing Enterobacterales: Insights from Comparative Genomics

  • Alexander Tristancho-Baró,
  • Ana Isabel López-Calleja,
  • Ana Milagro,
  • Mónica Ariza,
  • Víctor Viñeta,
  • Blanca Fortuño,
  • Concepción López,
  • Miriam Latorre-Millán,
  • Laura Clusa and
  • David Badenas-Alzugaray
  • + 3 authors

Background/Objectives: Cefiderocol is a novel siderophore cephalosporin with potent in vitro activity against a broad spectrum of Gram-negative bacteria, including carbapenemase-producing Enterobacterales (CPE). However, the recent emergence of resis...

  • Review
  • Open Access
2 Citations
2,707 Views
19 Pages

Antibiotic Treatment vs. Non-Antibiotic Treatment in Bovine Clinical Mastitis During Lactation with Mild and Moderate Severity

  • Franziska Nankemann,
  • Stefanie Leimbach,
  • Julia Nitz,
  • Anne Tellen,
  • Nicole Wente,
  • Yanchao Zhang,
  • Doris Klocke,
  • Isabel Krebs,
  • Stephanie Müller and
  • Sabrina Teich
  • + 4 authors

Background/Objectives: This review aimed to compare the efficacy of antibiotic treatment vs. non-antibiotic treatment in mild and moderate clinical mastitis in lactating dairy cows, categorized by the causative pathogen. Methods: The initial systemat...

  • Article
  • Open Access
1,496 Views
14 Pages

Antimicrobial resistance (AMR) represents a critical global health threat, with inappropriate antibiotic self-medication (ASM) being a key contributor. China—as the world’s largest antibiotic consumer—faces significant challenges de...

  • Article
  • Open Access
3 Citations
1,882 Views
14 Pages

Objectives: Carbapenem-resistant Gram-negative bacteria (CR-GNB) infections in intensive care units (ICUs) are increasingly prevalent and associated with high mortality. This study aimed to investigate the distribution of isolated bacteria and determ...

  • Article
  • Open Access
1,017 Views
16 Pages

Antimicrobial Peptides SET-M33L and SET-M33L-PEG Are Promising Agents Against Strong Biofilm-Forming P. aeruginosa, Including Multidrug-Resistant Isolates

  • Alessio Fontanot,
  • Peter D. Croughs,
  • Clelia Cortese,
  • Adrianus C. J. M. de Bruijn,
  • Chiara Falciani,
  • Alessandro Pini,
  • Isabella Ellinger,
  • Wendy W. J. Unger and
  • John P. Hays

Background: The antimicrobial peptides (AMPs) SET-M33L and SET-M33L-PEG were investigated against 10 clinical isolates of P. aeruginosa. Methods: Their minimum inhibitory concentrations (MICs), minimum bactericidal concentrations (MBCs), and minimum...

  • Review
  • Open Access
3 Citations
4,260 Views
32 Pages

Multifaceted Biological Properties of Verbascoside/Acteoside: Antimicrobial, Cytotoxic, Anti-Inflammatory, and Immunomodulatory Effects

  • Mirjana Marčetić,
  • Biljana Bufan,
  • Milica Drobac,
  • Jelena Antić Stanković,
  • Nevena Arsenović Ranin,
  • Marina T. Milenković and
  • Dragana D. Božić

Verbascoside is a polyphenolic compound that belongs to the phenylethanoid glucosides. It occurs in more than 220 plant species. The species with high content of this compound are used in folk medicine, and in modern phytotherapy, mostly based on its...

  • Article
  • Open Access
3 Citations
4,857 Views
12 Pages

Halicin: A New Approach to Antibacterial Therapy, a Promising Avenue for the Post-Antibiotic Era

  • Imane El Belghiti,
  • Omayma Hammani,
  • Fatima Moustaoui,
  • Mohamed Aghrouch,
  • Zohra Lemkhente,
  • Fatima Boubrik and
  • Ahmed Belmouden

Background: The global spread of antibiotic-resistant bacteria presents a major public health challenge and necessitates the development of innovative antimicrobial agents. Artificial intelligence (AI)-driven drug discovery has recently enabled the r...

  • Article
  • Open Access
1 Citations
920 Views
13 Pages

Background: Antimicrobial resistance (AMR) is a global threat that affects humans, animals, plants, the environment, societies, and economies—requiring urgent coordinated action. In May 2015, the World Health Assembly (WHA) adopted the Global A...

  • Review
  • Open Access
1 Citations
1,294 Views
13 Pages

Potential Shifts in the Oral Microbiome Induced by Bariatric Surgery—A Scoping Review

  • Zuzanna Ślebioda,
  • Hélène Rangé,
  • Marta Strózik-Wieczorek and
  • Marzena Liliana Wyganowska

Background: The oral microbiome differs in obese patients compared to normal-weight subjects. Microbiologic shifts very often appear after surgical interventions such as bariatric surgery (BS) and in immunocompromised patients. However, the oral micr...

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Antibiotics - ISSN 2079-6382