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Antibiotics, Volume 14, Issue 7

July 2025 - 110 articles

Cover Story: Platelet concentrates (PCs), used to treat patients with bleeding disorders, are stored at 20–24 °C to maintaining platelet functionality. These conditions also sustain the growth of bacteria such as Staphylococcus aureus, which poses an important safety risk to transfusion patients as it reaches clinically significant levels and produces virulence factors during PC storage. Previous studies have demonstrated that Staphylococcus spp. grown in PCs display upregulation of genes encoding for antimicrobial resistance and virulence. To expand the current knowledge, this study aimed to test whether the increase in the norB efflux pump expression observed in PCs translates into heightened quinolone resistance. Furthermore, the role of the NorB efflux pump on S. aureus virulence was investigated using a Bombyx mori (silkworm) animal model. View this paper
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Articles (110)

  • Article
  • Open Access
1,509 Views
22 Pages

Genomic and Metabolomic Analysis of the Endophytic Fungus Alternaria alstroemeriae S6 Isolated from Veronica acinifolia: Identification of Anti-Bacterial Properties and Production of Succinic Acid

  • Farkhod Eshboev,
  • Alex X. Gao,
  • Akhror Abdurashidov,
  • Kamila Mardieva,
  • Asadali Baymirzaev,
  • Mirzatimur Musakhanov,
  • Elvira Yusupova,
  • Shengying Lin,
  • Meixia Yang and
  • Tina T. X. Dong
  • + 3 authors

Background: Endophytic fungi are prolific sources of bioactive metabolites with potential in pharmaceutical and biotechnological applications. Methods: Here, the endophytic fungus, Alternaria alstroemeriae S6, was isolated from Veronica acinifolia (s...

  • Article
  • Open Access
1,277 Views
11 Pages

Background: Oral candidiasis (OC) and vulvovaginal candidiasis (VVC) are infections caused by species belonging to the genus Candida. In Chile, epidemiological studies on OC/VVC are scarce, leading to an overestimation of the prevalence of C. albican...

  • Article
  • Open Access
781 Views
16 Pages

Epidemiological Surveillance, Variability, and Evolution of Isolates Belonging to the Spanish Clone of the 4,[5],12:i:- Monophasic Variant of Salmonella enterica Serovar Typhimurium

  • Xenia Vázquez,
  • Patricia García,
  • Javier Fernández,
  • Víctor Ladero,
  • Carlos Rodríguez-Lucas,
  • Jürgen J. Heinisch,
  • Rosaura Rodicio and
  • M. Rosario Rodicio

Background/Objective: The present study focused on the analysis of the Spanish clone belonging to the successful 4,[5],12:i:- monophasic variant of Salmonella enterica serovar Typhimurium. Methods: All isolates of the clone recovered in a Spanish reg...

  • Article
  • Open Access
3 Citations
3,595 Views
19 Pages

Barriers to Compliance with National Guidelines Among Children Hospitalized with Community-Acquired Pneumonia in Vietnam and the Implications

  • Thuy Thi Phuong Nguyen,
  • Huong Thi Thu Vu,
  • Anh Minh Hoang,
  • An Minh Ho,
  • Israel Abebrese Sefah,
  • Brian Godman and
  • Johanna C. Meyer

Background: Community-acquired pneumonia (CAP) is the leading cause of death in infants aged 1–59 months. Concurrent with this, there is a need to prescribe antibiotics wisely in Vietnam due to concerns with rising antimicrobial resistance (AMR...

  • Article
  • Open Access
4,607 Views
15 Pages

Background: Early identification of sepsis is critical for improving outcomes, particularly in low-resource emergency settings. In Thai community hospitals, where physicians may not always be available, triage is often nurse-led. Selecting accurate a...

  • Article
  • Open Access
1 Citations
914 Views
14 Pages

Antimicrobial Efficacy of Impregnated Human Acellular Dermal Substitutes in Burn Wound Models

  • Marianna Hajská,
  • Elena Kurin,
  • Silvia Bittner Fialová,
  • Marian Vidiščák and
  • Arpád Panyko

Burn wound infections remain a major clinical challenge due to delayed healing, scarring, and the risk of sepsis, especially when complicated by multidrug-resistant (MDR) Gram-negative pathogens and biofilm formation. Acellular dermal matrices (ADMs)...

  • Article
  • Open Access
1 Citations
953 Views
15 Pages

Resistome and Phylogenomics of Escherichia coli Strains Obtained from Diverse Sources in Jimma, Ethiopia

  • Mulatu Gashaw,
  • Esayas Kebede Gudina,
  • Guenter Froeschl,
  • Ralph Matar,
  • Solomon Ali,
  • Liegl Gabriele,
  • Amelie Hohensee,
  • Thomas Seeholzer,
  • Arne Kroidl and
  • Andreas Wieser

Introduction: In recent years, antimicrobial resistance (AMR) rates have increased significantly in bacterial pathogens, particularly extended beta-lactam resistance. This study aimed to investigate resistome and phylogenomics of Escherichia coli (E....

  • Review
  • Open Access
3 Citations
3,301 Views
18 Pages

Antibiotic-loaded cement spacers play a crucial role in two-stage revision arthroplasty of infected total hip and knee prostheses. There is still controversy regarding whether the elution from antibiotic-loaded cement spacers is greater than the MIC...

  • Article
  • Open Access
866 Views
13 Pages

Investigation of WQ-3810, a Fluoroquinolone with a High Potential Against Fluoroquinolone-Resistant Mycobacterium avium

  • Sasini Jayaweera,
  • Pondpan Suwanthada,
  • David Atomanyi Barnes,
  • Charlotte Poussier,
  • Tomoyasu Nishimura,
  • Naoki Hasegawa,
  • Yukiko Nishiuchi,
  • Jeewan Thapa,
  • Stephen V. Gordon and
  • Hyun Kim
  • + 2 authors

Background/Objectives: Mycobacterium avium, a member of Mycobacterium avium complex (MAC), is an emerging opportunistic pathogen causing MAC-pulmonary disease (PD). Fluoroquinolones (FQs), along with ethambutol (EMB) and rifampicin, are recommen...

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Antibiotics - ISSN 2079-6382